Results 51 to 60 of about 1,740 (174)

Anti‐Metalloprotease P‐I Single‐Domain Antibodies: Tools for Next‐Generation Snakebite Antivenoms

BioMed Research International, Volume 2022, Issue 1, 2022., 2022
In order to address the global antivenom crisis, novel antivenoms need to present high therapeutic efficacy, broad neutralization ability against systemic and local damage, sufficient safety, and cost‐effectiveness. Due to biological characteristics of camelid single‐domain antibodies (VHH) such as high affinity, their ability to penetrate dense ...
Marcela C. S. Silva, Soraya S. Pereira, Marilia P. Gouveia, Marcos B. Luiz, Rosa M. O. Sousa, Anderson M. Kayano, Aleff F. Francisco, Nidiane D. R. Prado, Leandro S. M. Dill, Marcos R. M. Fontes, Fernando B. Zanchi, Rodrigo G. Stabeli, Andreimar M. Soares, Juliana P. Zuliani, Carla F. C. Fernandes, Carla F. C. Fernandes   +15 more
wiley   +1 more source

Bacterial phospholipases C with dual activity: phosphatidylcholinesterase and sphingomyelinase

FEBS Open Bio, Volume 11, Issue 12, Page 3262-3275, December 2021., 2021
The aim of this review is to discuss similarities and differences among the most explored bacterial enzymes that have both phospholipase C and sphingomyelinase C activities. The structural aspects of three of those enzymes, their substrate specificity, and in silico substrate docking analysis are discussed, as well as their mechanisms of toxicity in ...
Laura Monturiol‐Gross, Fabian Villalta‐Romero, Marietta Flores‐Díaz, Alberto Alape‐Girón   +3 more
wiley   +1 more source

Repurposing cancer drugs, batimastat and marimastat, to inhibit the activity of a group I metalloprotease from the venom of the Western Diamondback rattlesnake, Crotalus atrox [PDF]

, 2020
Snakebite envenomation causes over 140,000 deaths every year predominantly in developing countries. As a result, it is one of the most lethal neglected tropical diseases.
Bicknell, Andrew B., Lakshminarayanan, Karthik, Layfield, Harry J., Mehmi, Amita, Patel, Ketan, Ravishankar, Divyashree, Salim, Anika, Sonavane, Medha, Trim, Steven A., Vaiyapuri, Rajendran, Vaiyapuri, Sakthivel, Vallance, Thomas M., Williams, Harry F.   +12 more
core   +1 more source

Diclofenac Resensitizes Methicillin‐Resistant Staphylococcus aureus to β‐Lactams and Prevents Implant Infections

Advanced Science, Volume 8, Issue 13, July 7, 2021., 2021
Diclofenac enhances the sensitivity of methicillin‐resistant Staphylococcus aureus toward the β‐lactam antibiotics, which help to circumvent drug resistance and improve the antibacterial efficacy of conventional antibiotics. Besides, murine implant infection models show that diclofenac combined with oxacillin, can alleviate MRSA infections. Mechanistic
Shutao Zhang, Xinhua Qu, Haozheng Tang, You Wang, Hongtao Yang, Weien Yuan, Bing Yue   +6 more
wiley   +1 more source

Snake Venomics and Antivenomics of Bothrops diporus, a Medically Important Pitviper in Northeastern Argentina [PDF]

, 2015
Snake species within genus Bothrops are responsible for more than 80% of the snakebites occurring in South America. The species that cause most envenomings in Argentina, B.
Calvete, Juan J., Gay, Claudia Carolina, Pla, Davinia, Sanz, Libia   +3 more
core   +5 more sources

Novel Mutant Phospholipase D from Hemiscorpius lepturus Acts as A Highly Immunogen in BALB/c Mice Against the Lethality of Scorpion Venom

Molecules, 2020
Hemiscorpius lepturus (H. lepturus) which belongs to the Scorpionidae family, is the deadliest scorpion in Iran. It causes pathological manifestations like dermonecrosis, hemolysis, renal failure, necrotic ulcers, and in some cases, even death. The venom
Abouzar Soleimani Moez, Reza H. Sajedi, Kamran Pooshang Bagheri, Jean-Marc Sabatier, Delavar Shahbazzadeh   +4 more
doaj   +1 more source

A Novel Hyaluronidase from Brown Spider (Loxosceles intermedia) Venom (Dietrich's Hyaluronidase): From Cloning to Functional Characterization [PDF]

, 2013
Loxoscelism is the designation given to clinical symptoms evoked by Loxosceles spider's bites. Clinical manifestations include skin necrosis with gravitational spreading and systemic disturbs. the venom contains several enzymatic toxins.
Chaim, Olga Meiri, Ferrer, Valeria Pereira, Gremski, Luiza Helena, Gremski, Waldemiro, Mari, Thiago Lopes de, Nader, Helena Bonciani, Senff-Ribeiro, Andrea, Silva, Dilza Trevisan, Silveira, Rafael Bertoni da, Veiga, Silvio Sanches   +9 more
core   +4 more sources

Verified envenomations by crevice weaver spiders (genus Kukulcania): Bites are of minor expression but the spiders are commonly misidentified as medically important brown recluses (genus Loxosceles) in North America

Toxicon: X, 2022
From southern North America, five verified bites by crevice weaver spiders, Kukulcania spp. (Filistatidae), are presented here, three of which are pediatric cases. Although the envenomation manifestations were of minimal expression, the salient aspect of
Richard S. Vetter
doaj   +1 more source

Transcriptome and venom proteome of the box jellyfish Chironex fleckeri [PDF]

, 2015
Background: The box jellyfish, Chironex fleckeri, is the largest and most dangerous cubozoan jellyfish to humans. It produces potent and rapid-acting venom and its sting causes severe localized and systemic effects that are potentially life-threatening ...
Brinkman, Diane L., Dash, Debasis, Jia, Xinying, Kumar, Dhirendra, Kvaskoff, David, Mulvenna, Jason, Potriquet, Jeremy   +6 more
core   +1 more source

Spider bites of medical significance in the mediterranean area: misdiagnosis, clinical features and management [PDF]

, 2020
Despite the disrepute spiders have had for centuries, their bite is a rare occurrence. In the Mediterranean area, only two of the numerous known species are considered of medical significance: Latrodectus tredecimguttatus and Loxosceles rufescens. Spider
Bennardo, Luigi, Duca, Ester Del, Fusto, Gabriele, Mazzuca, Daniela, Nisticò, Steven Paul, Patruno, Cataldo, Tamburi, Federica   +6 more
core   +1 more source