Results 81 to 90 of about 1,740 (174)

Biochemical Characterization, Action on Macrophages, and Superoxide Anion Production of Four Basic Phospholipases A2 from Panamanian Bothrops asper Snake Venom

BioMed Research International, Volume 2013, Issue 1, 2013., 2013
Bothrops asper (Squamata: Viperidae) is the most important venomous snake in Central America, being responsible for the majority of snakebite accidents. Four basic PLA2s (pMTX‐I to ‐IV) were purified from crude venom by a single‐step chromatography using a CM‐Sepharose ion‐exchange column (1.5 × 15 cm).
Aristides Quintero Rueda, Isela González Rodríguez, Eliane C. Arantes, Sulamita S. Setúbal, Leonardo de A. Calderon, Juliana P. Zuliani, Rodrigo G. Stábeli, Andreimar M. Soares, Luis A. Ponce Soto   +8 more
wiley   +1 more source

Brown Spider Venom Phospholipase-D Activity upon Different Lipid Substrates

Toxins, 2023
Brown spider envenomation results in dermonecrosis, characterized by an intense inflammatory reaction. The principal toxins of brown spider venoms are phospholipase-D isoforms, which interact with different cellular membrane components, degrade ...
Daniele Chaves-Moreira, Luiza Helena Gremski, Fábio Rogério de Moraes, Larissa Vuitika, Ana Carolina Martins Wille, Jorge Enrique Hernández González, Olga Meiri Chaim, Andrea Senff-Ribeiro, Raghuvir Krishnaswamy Arni, Silvio Sanches Veiga   +9 more
doaj   +1 more source

Haemotixic snake venoms: their functional activity, impact on snakebite victims and pharmaceutical promise [PDF]

, 2017
Snake venoms are mixtures of numerous proteinacious components that exert diverse functional activities on a variety of physiological targets. Because the toxic constituents found in venom vary from species to species, snakebite victims can present with ...
Abubakar, Alirol, Alirol, Amiconi, Andrião-Escarso, Antonypillai, Arlinghaus, Arnold, Berling, Calvete, Calvete, Camargo, Casewell, Casewell, Casewell, Casewell, Casewell, Chakrabarty, Chippaux, Chippaux, Chippaux, Cousin, Deshpande, Durban, Earl, Escalante, Ferreira, Flight, Flight, Fox, Fry, Fry, Funk, Greene, Gutiérrez, Gutiérrez, Habib, Han, Harrison, Harrison, Harrison, Hutton, Illig, Isbister, Isbister, Isbister, Kasturiratne, Katkar, Kerkkamp, King, Kini, Lu, Lynch, Maduwage, Markland, Marrakchi, Marsh, Massey, McCleary, Modesto, Moll, Mosquera, Moura-da-Silva, Nowak, Oyama, Peerlinck, Phillips, Pirkle, Pla, Reza, Reza, Rivel, Rosing, Rucavado, Scarborough, Segura, Shimokawa, Siigur, Silva, Smith, Stocker, Stocker, Tan, Tan, Tan, Teixeira, Triplett, Vidal, Visser, Vonk, Vonk, Warrell, Warrell, Williams, Williams, Xu, Xu, Zhang   +97 more
core   +4 more sources

Feasibility of using a combination of staphylococcal superantigen‐like proteins 3, 7 and 11 in a fusion vaccine for Staphylococcus aureus

Immunology &Cell Biology, Volume 102, Issue 5, Page 365-380, May‐June 2024.
This study demonstrates that three secreted immune evasion factors from the staphylococcal superantigen‐like (SSL) protein family—SSL3, 7 and 11—can be successfully fused into a polyprotein. Mice immunized with a functionally inactive version of the polyprotein in the squalene‐based adjuvant (AddaVax), but not the equivalent amount of the individual ...
Janlin Ying Hui Chan, Fiona Clow, Victoria Pearson, Ries J Langley, John D Fraser, Fiona J Radcliff   +5 more
wiley   +1 more source

Artemia salina as an animal model for the preliminary evaluation of snake venom-induced toxicity

Toxicon: X, 2021
Lethality and cytotoxicity assays of snake venoms and their neutralization by antivenom require many mice for the experiments. Recent developments have prompted researchers to seek alternative strategies that minimize the use of mice in line with Russel ...
Mitchel Otieno Okumu, James Mucunu Mbaria, Joseph Kangangi Gikunju, Paul Gichohi Mbuthia, Vincent Odongo Madadi, Francis Okumu Ochola, Mercy Seroney Jepkorir   +6 more
doaj   +1 more source

Prospecting Local Treatments Used in Conjunction with Antivenom Administration Following Envenomation Caused by Animals: A Systematic Review

Toxins, 2023
Envenomation caused by venomous animals may trigger significant local complications such as pain, edema, localized hemorrhage, and tissue necrosis, in addition to complications such as dermonecrosis, myonecrosis, and even amputations.
Érica S. Carvalho, Isadora Oliveira, Thaís P. Nascimento, Alexandre Vilhena da Silva Neto, Brenda A. S. Leal, Felipe Q. Araújo, Bruno F. V. Julião, Andrea R. N. Souza, Andreza W. Abrahim, Bruna B. O. Macedo, Jéssica T. S. de Oliveira, Fan Hui Wen, Manuela B. Pucca, Wuelton M. Monteiro, Jacqueline A. G. Sachett   +14 more
doaj   +1 more source

A Polychaete’s Powerful Punch: Venom Gland Transcriptomics of Glycera Reveals a Complex Cocktail of Toxin Homologs [PDF]

, 2014
© The Author(s) 2014. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/
Abdel-Rahman, Aird, Alarcon-Chaidez, Altschul, Alves-Silva, Ambrose, Anatriello, Anderluh, Bakrac, Bakrac, Balasubramanian, Barlic, Binford, Binford, Björn M. von Reumont, Bon, Borda, Bradnam, Brinkman, Böggemann, Casewell, Castaneda, Castaneda, Chagas, Chang, Chen, Christoph Bleidorn, Conesa, Conesa, Cuypers, Dan Sykes, Darriba, De Colibus, Earl, Eddy, Fauchald, Favreau, Fernandes-Pedrosa, Francischetti, Fry, Fry, Garb, Garcia, Garcia-Ortega, Ghadessy, Giese, Giray, Grabherr, Hargreaves, He, Honma, Jungo, Jörg Hetmank, Kagan, Katoh, Kawashima, Khalturin, King, King, Kircher, Kiriake, Klawe, Kobayashi, Koua, Krebs, Kristan, Kvist, Lahcen I. Campbell, Lars Hering, Lin, Low, Low, Manaranche, Mancheno, Margres, Martin, Meunier, Meunier, Meyer, Michel, Michel, Min, Morgenstern, Morgenstern, Moses, Nakamura, Olivera, O’Neil, Peng, Pennington, Petersen, Rangaraju, Rigoni, Rokyta, Ronald A. Jenner, Rosenberg, Rouse, Safavi-Hemami, Sandy Richter, Schenning, Shiomi, Shiomi, Smeds, Stamatakis, Sukumwang, Sunagar, Terrat, Ueda, Ungerer, Violette, von Reumont, Vonk, Warren, Watala, Weston, Whittington, Wong, Zdobnov, Zhang, Zimmerberg, Zobel-Thropp   +120 more
core   +1 more source

Biotechnological potential of Phospholipase D for Loxosceles antivenom development [PDF]

, 2020
Loxoscelism is one of the most important forms of araneism in South America. The Health Authorities from countries with the highest incidence and longer history in registering loxoscelism cases indicate that specific antivenom should be administered ...
Cascone, Osvaldo, de Roodt, Adolfo Rafael, Fingermann, Matias, Miranda, Maria Victoria   +3 more
core   +1 more source

Brown Spiders’ Phospholipases-D with Potential Therapeutic Applications: Functional Assessment of Mutant Isoforms

Biomedicines, 2021
Phospholipases-D (PLDs) found in Loxosceles spiders’ venoms are responsible for the dermonecrosis triggered by envenomation. PLDs can also induce other local and systemic effects, such as massive inflammatory response, edema, and hemolysis.
Thaís Pereira da Silva, Fernando Jacomini de Castro, Larissa Vuitika, Nayanne Louise Costacurta Polli, Bruno César Antunes, Marianna Bóia-Ferreira, João Carlos Minozzo, Ricardo Barros Mariutti, Fernando Hitomi Matsubara, Raghuvir Krishnaswamy Arni, Ana Carolina Martins Wille, Andrea Senff-Ribeiro, Luiza Helena Gremski, Silvio Sanches Veiga   +13 more
doaj   +1 more source

Biofilm formation in catheter-related infections by Panton-Valentine leukocidin-producing Staphylococcus aureus [PDF]

, 2017
The use of invasive techniques, such as intravascular catheter insertion, and the formation of biofilms in several devices by methicillin-resistant Staphylococcus aureus (MRSA) have contributed to the increased number of septic patients, morbidity and ...
Fábio Aguiar-Alves, Giorgio Silva-Santana, Kátia C. Lenzi-Almeida, Vânia G. S. Lopes   +3 more
core   +1 more source