Results 161 to 170 of about 5,859,979 (225)

Discovery, Characterization and Synthetic Application of a Promiscuous Nonheme Iron Biocatalyst with Dual Hydroxylase/Desaturase Activity. [PDF]

Angew Chem Int Ed Engl
Xu H, Zhao J, Renata H.
europepmc   +1 more source

Mechanistic Studies of Fatty Acid Activation by CYP152 Peroxygenases Reveal Unexpected Desaturase Activity. [PDF]

ACS Catal, 2019
Pickl M, Kurakin S, Cantú Reinhard FG, Schmid P, Pöcheim A, Winkler CK, Kroutil W, de Visser SP, Faber K.   +8 more
europepmc   +1 more source

Polymorphisms in FADS2 correlated with altered desaturase activity in a type-2 diabetic cohort

, 2013
[[abstract]]Recent evidence reveals that single nucleotide polymorphisms (SNP) in fatty acid desaturase 2 (FADS2) is correlated with alteration in blood fatty acid profile in some ethnic groups.
Huang, PC;Jhang, HR;Hsu, CC;Kothapalli, K;Brenna, T;Huang, MC
core  

AMPK‐Mediated Lipid Metabolic Reprogramming in Cancer: From Mechanisms to Targeted Therapies

Cell Biochemistry and Function, Volume 44, Issue 10, October 2026.
ABSTRACT AMP‐activated protein kinase (AMPK), a key regulator of cellular energy metabolism, is activated under conditions of energy stress to restore metabolic homeostasis by promoting catabolic pathways and inhibiting anabolic processes such as lipid synthesis. Multiple key molecules involved in lipid metabolism are regulated by AMPK, and its role in
Yuying Chen, Wen Liu, Bing Luo
wiley   +1 more source

Fads2 knockout mice reveal that ALA prevention of hepatic steatosis is dependent on delta-6 desaturase activity. [PDF]

J Lipid Res
MacLeod B, Wang C, Brown LH, Borkowski E, Nakamura MT, Wells KR, Brunt KR, Harasim-Symbor E, Chabowski A, Mutch DM.   +9 more
europepmc   +1 more source

Extracellular Vesicle‐Encapsulated Small RNAs From Clostridium Butyricum Modulate Host Intestinal Lipid Metabolism

Journal of Extracellular Vesicles, Volume 15, Issue 10, October 2026.
Extracellular vesicles (EVs) derived from C. butyricum can enter intestinal epithelial cells and mediate the anti‐lipid absorption effects by delivering miRNA‐like RNAs (milRNAs), particularly milRNA‐3020179, which primarily targeted host genes majorly including PPARα. Deletion of milRNA‐3020179 in C. butyricum abolished its effects on lipid deposition
Hong Hu, Yiwen He, Jing Liang, Qi Han, Xuqing Liang, Guangtian Cao, Yulong Tang, Liuqin He, Yulong Yin, Xihong Zhou   +9 more
wiley   +1 more source

Determination of fatty acid uptake and desaturase activity in mammalian cells by NMR-based stable isotope tracing. [PDF]

Anal Chim Acta
Lin P, Sledziona J, Akkaya-Colak KB, Mihaylova MM, Lane AN.   +4 more
europepmc   +1 more source

Organoids: Current Applications and Future Directions

MedComm, Volume 7, Issue 10, October 2026.
Organoids are three‐dimensional multicellular structures derived from stem cells or primary tissues that recapitulate key structural and functional features of native organs. Advances in stem cell biology, biomaterials, and bioengineering have established organoids as powerful platforms for studying human development and disease mechanisms, drug ...
Yueqi Leng, Yue Wang, Canhui Cao, Feng Deng, Weisi Lian, Xingtong Chen, Mingmei Lin, Zhonghong Zeng, Dan Mo, Shangqi Li, Yilei He, Yang Yu, Heng Pan, Ping Zhou, Rong Li   +14 more
wiley   +1 more source

Selection scan in Native Americans of Mexico identifies FADS2 rs174616: Evidence of gene-diet interactions affecting lipid levels and Delta-6-desaturase activity. [PDF]

Heliyon
Romero-Hidalgo S, Sagaceta-Mejía J, Villalobos-Comparán M, Tejero ME, Domínguez-Pérez M, Jacobo-Albavera L, Posadas-Sánchez R, Vargas-Alarcón G, Posadas-Romero C, Macías-Kauffer L, Vadillo-Ortega F, Contreras-Sieck MA, Acuña-Alonzo V, Barquera R, Macín G, Binia A, Guevara-Chávez JG, Sebastián-Medina L, Menjívar M, Canizales-Quinteros S, Carnevale A, Villarreal-Molina T.   +21 more
europepmc   +1 more source

Genome-Wide Association Studies of Estimated Fatty Acid Desaturase Activity in Serum and Adipose Tissue in Elderly Individuals: Associations with Insulin Sensitivity. [PDF]

Nutrients, 2018
Marklund M, Morris AP, Mahajan A, Ingelsson E, Lindgren CM, Lind L, Risérus U.   +6 more
europepmc   +1 more source