Results 171 to 180 of about 5,859,979 (225)

Dapagliflozin Attenuates NKCC2 Protein Expression and Alleviates Diabetic Kidney Disease in Salt Loaded‐Hypertensive Diabetic Db/Db Mice

FASEB BioAdvances, Volume 8, Issue 10, October 2026.
In salt‐loaded, hypertensive diabetic db/db mice with diabetic kidney disease, dapagliflozin lowered blood pressure and reduced tubular and glomerular injury. Mechanistically, dapagliflozin increased cullin E3 ligase abundance, promoting degradation of NKCC2.
Zenab Shahzad, Niharika Bala, Arooba Illyas, Amir Kazory, Indra Chandrasekar, Abdel A. Alli   +5 more
wiley   +1 more source

Effect of high carbohydrate diet on elongase and desaturase activity and accompanying gene expression in rat's liver. [PDF]

Genes Nutr, 2017
Drąg J, Goździalska A, Knapik-Czajka M, Gawędzka A, Gawlik K, Jaśkiewicz J.   +5 more
europepmc   +1 more source

Malaria mosquito antimicrobial defence requires immunity and detoxification gene regulation by Lola

Insect Molecular Biology, Volume 35, Issue 5, Page 576-593, October 2026.
Malaria mosquito antimicrobial defence requires upregulation of lola. Attenuation of lola in the midgut of Anopheles albimanus mosquitoes inhibits the upregulation of immunity genes induced by challenge. Putative target genes of the Lola transcription factor were revealed by lola attenuation, including Cecropin‐C, Draper, PPAF2, Clip‐domain serine ...
Heidi Espadas‐Álvarez, Verónica Valverde‐Garduño   +1 more
wiley   +1 more source

Lipid Accumulation Promotes Tumorigenic Behaviour of Colorectal Cancer Cells

Journal of Cellular and Molecular Medicine, Volume 30, Issue 19, October 2026.
ABSTRACT Obesity and hyperlipidemia are risk factors for the development and progression of different types of cancer including colorectal cancer (CRC). The underlying mechanisms are only incompletely understood. The aim of this study was to assess the impact of hyperlipidemic conditions on tumorigenic behaviour of CRC cells and the effect of obesity ...
Tatjana Itzenhäuser, Fulya Suzan Schildt, Seraphine Jochem, Judith Sommer, Michael Stürzl, Elisabeth Naschberger, Anja Katrin Boßerhoff, Claus Hellerbrand   +7 more
wiley   +1 more source

Plasma stearoyl-CoA desaturase activity indices and bile acid concentrations after a low-fat meal: association with a genetic variant in the FTO gene. [PDF]

Diabetes Metab Syndr Obes, 2018
Skuladottir GV, Oskarsdottir H, Pisanu C, Sjödin M, Lindberg J, Mwinyi J, Schiöth HB.   +6 more
europepmc   +1 more source

Role of the tomato MARS1/ROUGH gene encoding a LYSINE‐SPECIFIC HISTONE DEMETHYLASE 1 in adventitious root and fruit skin formation

Journal of Integrative Plant Biology, Volume 68, Issue 10, Page 3644-3669, October 2026.
The tomato mars1/rough mutant displays enhanced root regeneration and rough fruits due to ectopic cell proliferation. The causal gene encodes a lysine‐specific histone demethylase that normally maintains gene silencing. Its loss alters histone methylation, upregulating several genes, including those B‐type cyclins involved in tissue‐specific cellular ...
Eduardo Larriba, Cécile Bres, Aurora Alaguero‐Cordovilla, Riyazuddin Riyazuddin, Qingyi Wang, Johann Petit, Jean‐Philippe Mauxion, Lara Caballero, David Latrasse, Bénédicte Bakan, Rim Brik‐Chaouche, David Esteve‐Bruna, Moussa Benhamed, Christophe Rothan, José Manuel Pérez‐Pérez   +14 more
wiley   +1 more source

Rates of Evolution Differ Between Cell Types Identified by Single‐Cell RNAseq in Threespine Stickleback

Molecular Ecology, Volume 35, Issue 19, October 2026.
ABSTRACT Rates of evolutionary change vary by gene. While some broad gene categories are highly conserved with little divergence over time, others undergo continuous selection pressure and are highly divergent among populations or species. But such comparative evolutionary studies rely on gene ontology categories that are rarely validated in the study ...
Maria L. Rodgers, Swapna Subramanian, Lauren E. Fuess, Wan He, Samuel V. Scarpino, Andrea J. Roth‐Monzón, Daniel L. Jeffries, Martine Seignon, Kathryn Milligan‐McClellan, Rebecca Carrier, Natalie C. Steinel, Daniel I. Bolnick   +11 more
wiley   +1 more source

Mutual antagonism between auxin and diacylglycerol acyltransferase 2 regulates high‐temperature‐induced hypocotyl elongation

New Phytologist, Volume 252, Issue 1, Page 222-240, October 2026.
Proposed model for auxin–DGAT2 crosstalk regulating high‐temperature‐induced hypocotyl elongation. Summary Cell elongation is a fundamental process in plant growth and development, and it is significantly affected by temperature changes. While the signaling mechanisms driving high‐temperature‐induced cell elongation have been extensively studied, the ...
Mohinur Khamzaaliyeva, Punita Lalchand, Didier‐Deschamps Ashley, Xue Pan   +3 more
wiley   +1 more source

The Association of Polyunsaturated Fatty Acid δ-5-Desaturase Activity with Risk Factors for Type 2 Diabetes Is Dependent on Plasma ApoB-Lipoproteins in Overweight and Obese Adults. [PDF]

J Nutr, 2019
Lamantia V, Bissonnette S, Provost V, Devaux M, Cyr Y, Daneault C, Rosiers CD, Faraj M.   +7 more
europepmc   +1 more source

ERF Transcription Factor NaERFIDOG Regulates JA‐Induced Defence and Growth Inhibition in Nicotiana attenuata Upon Alternaria alternata Infection

Plant Biotechnology Journal, Volume 24, Issue 10, Page 5266-5283, October 2026.
ABSTRACT Jasmonate (JA) regulates defence responses in plants. However, JA‐induced defence often results in growth inhibition. This process is largely mediated by MYC2, the master regulator of JA signalling. Nevertheless, the underlying molecular mechanisms have not yet been fully uncovered.
Luyan Zhao, Na Song, Lei Wang, Jinsong Wu   +3 more
wiley   +1 more source