HUMORAL LIPID DESIALYLATING ANTIBODY IGG1
After repeated antigen challenge, mice can regulate the anaphylaxis. The regulation was suggested to be induced by decrease of negative electric change in antibody IgG1 glycosylation. Sialic acid has negative electric change, and IgG1 has it in the sugar chain structure.
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Inhibition of human FcγRIII prevents platelet destruction in a dual-humanized murine model of FNAIT. [PDF]
Tawhidi Z +11 more
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Biomaterial engineering of the tumor glycocalyx for cancer immunotherapy. [PDF]
Guo Z +12 more
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Chemically Masked aPD-L1-Sialidase Conjugate for Tumor-Specific Desialylation and Immunotherapy. [PDF]
Zeng J +9 more
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The glycan fingerprint in immune thrombocytopenia. [PDF]
Nelson VS, Zlamal J, Kapur R.
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Targeting Siglec-engaging immunosuppressive sialoglycans to suppress prostate cancer bone metastasis. [PDF]
Peng Z +19 more
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Potential Mechanisms of Platelet Dysfunction and Bleeding in Acid Sphingomyelinase Deficiency. [PDF]
Sysoev M +3 more
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Sialic Acids in Kidney Disease: Immune Regulation, Complement Activation and Glomerular Injury. [PDF]
Spennacchio A +9 more
europepmc +1 more source
The asialoglycoprotein receptor 1 (ASGR1): emerging new roles in health and disease. [PDF]
Geremew D +3 more
europepmc +1 more source
Temporal gut microbiota dysbiosis links metabolic impairment, LDL desialylation, and accelerated atherosclerosis in LDLR<sup>-</sup>/<sup>-</sup> mice. [PDF]
Guan G +8 more
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