Results 91 to 100 of about 3,518 (193)

Desialylation accelerates platelet clearance after refrigeration and initiates GPIbα metalloproteinase-mediated cleavage in mice

, 2012
When refrigerated platelets are rewarmed, they secrete active sialidases, including the lysosomal sialidase Neu1, and express surface Neu3 that remove sialic acid from platelet von Willebrand factor receptor (VWFR), specifically the GPIbα subunit.
Stephen M. Cifuni, Wolfgang Bergmeier, Ulrich H. von Andrian, Qiyong Peter Liu, Hervé Falet, A. J. Gerard Jansen, Karin M. Hoffmeister, Denisa D. Wagner, Emma C. Josefsson, Robert Sackstein, Viktoria Rumjantseva, John H. Hartwig   +11 more
core   +1 more source

Assessing the function of pneumococcal neuraminidases NanA, NanB and NanC in in vitro and in vivo lung infection models using monoclonal antibodies

Virulence, 2018
Streptococcus pneumoniae isolates express up to three neuraminidases (sialidases), NanA, NanB and NanC, all of which cleave the terminal sialic acid of glycan-structures that decorate host cell surfaces. Most research has focused on the role of NanA with
Philipp Janesch, Harald Rouha, Adriana Badarau, Lukas Stulik, Irina Mirkina, Marisa Caccamo, Katharina Havlicek, Barbara Maierhofer, Susanne Weber, Karin Groß, Jacqueline Steinhäuser, Manuel Zerbs, Cecilia Varga, Ivana Dolezilkova, Sabine Maier, Gerhild Zauner, Nels Nielson, Christine A. Power, Eszter Nagy   +18 more
doaj   +1 more source

Sialic Acids in Health and Disease

Biologics
Vertebrate cell surfaces exhibit intricate arrangements of glycosaminoglycan polymers, which are primarily linked to lipids and proteins. Numerous soluble secreted proteins are also decorated with either individual sugar molecules or their polymers.
Gerardo N. Guerrero-Flores, Fayth M. Butler, Veronica L. Martinez Marignac, Guangyu Zhang, Fabio J. Pacheco, Danilo S. Boskovic   +5 more
doaj   +1 more source

Multirefractory primary immune thrombocytopenia; targeting the decreased sialic acid content

Platelets, 2019
Patients with multirefractory immune thrombocytopenia (ITP) have limited treatment options. Recent data suggest that specific anti-platelet antibodies may cause destruction of platelets by favoring platelet loss of sialic acid.
Nuria Revilla, Javier Corral, Antonia Miñano, Maria Eva Mingot-Castellano, Rosa Maria Campos, Francisco Velasco, Nicolas Gonzalez, Eva Galvez, Ruben Berrueco, Inmaculada Fuentes, Tomas Jose Gonzalez-Lopez, Maria Eugenia de la Morena-Barrio, Jose Ramon Gonzalez-Porras, Vicente Vicente, Maria Luisa Lozano   +14 more
doaj   +1 more source

Perspectives of Natural Products and Sialic Acid Mimetics as Modulators of Human Sialidases NEU1–3 in Atherosclerosis

Biomolecules
This narrative review summarizes current data on the role of desialylation of low-density lipoproteins (LDL) as a key initiating mechanism of atherogenesis that precedes oxidative modification. The structural and functional significance of sialic acid in
Tatyana I. Kovyanova, Vasily P. Karagodin, Daria D. Borodko, Ulyana V. Rozhkova, Stanislav A. Antonov, Aleksandra S. Utkina, Anastasia N. Vaganova   +6 more
doaj   +1 more source

Desialylation of cell surface insulin and IGF-I receptors differently modify the proliferative response of skeletal myoblasts to insulin [PDF]

, 2008
Previous data from our laboratory show that neuraminidase-1 (a subunit of the elastin receptor) can desialylate beta-subunits of the adjacent insulin-like growth factor 1 receptors (IGF-1R) on fibroblasts and arterial smooth muscle cells (SMCs), thereby ...
Arabkhari, Majid
core   +1 more source

Neuraminidase 1 activates insulin receptor and reverses insulin resistance in obese mice

Molecular Metabolism, 2018
Objectives: Neuraminidase 1 (NEU1) cleaves terminal sialic acids of glycoconjugates during lysosomal catabolism. It also modulates the structure and activity of cellular surface receptors affecting diverse pathways.
Anne Fougerat, Xuefang Pan, Victoria Smutova, Nikolaus Heveker, Christopher W. Cairo, Tarik Issad, Bruno Larrivée, Jeffrey A. Medin, Alexey V. Pshezhetsky   +8 more
doaj   +1 more source

Mouse Model of Low-density Lipoprotein Desialylation In Vivo

Current Medicinal Chemistry
Background: Atherosclerosis is a chronic disease characterized by the increased infiltration and retention of LDL particles in arterial walls. There are several mechanisms underlying atherogenesis, with the pro-atherogenic modifications of LDL playing a significant role.
Dmitry, Kashirskikh, Nelya, Chicherina, Victor, Glanz, Alexander, Orekhov, Igor, Sobenin   +4 more
openaire   +2 more sources

Inhibition of CCl4-induced liver inflammation and fibrosis by a NEU3 inhibitor.

PLoS ONE
Sialic acids are located on the ends of many glycoconjugates and are cleaved off by enzymes called sialidases (neuraminidases). Upregulation of neuraminidase 3 (NEU3) is associated with intestinal inflammation and colitis, neuroinflammation, and lung ...
Darrell Pilling, Trevor C Martinez, Richard H Gomer   +2 more
doaj   +1 more source

Lipopolysaccharide activates microglia via neuraminidase 1 desialylation of Toll‐like Receptor 4

, 2020
Most cell surface receptors are sialylated, i.e. have sialic acid as the terminal residue of their sugar chains, but can be desialylated by sialidases, such as neuraminidase 1 (Neu1).
David Hans Allendorf, Guy Charles Brown, Elske Helena Franssen   +2 more
core   +1 more source