Results 71 to 80 of about 3,518 (193)

Transforming Dihydroxyacetone Phosphate-Dependent Aldolases Mediated Aldol Reactions From Flask Reaction Into Cell-Based Synthesis & Studying The Mechanism Of Chemical Desialylation In The Life Processes [PDF]

, 2016
Dihydroxyacetone phosphate (DHAP)-dependent aldolases have been intensively studied and widely used in the synthesis of carbohydrates and complex polyhydroxylated molecules.
Wei, Mohui
core   +1 more source

Protocol for enzymatic desialylation of native apo-transferrin

, 2020
Experimental protocol for the enzymatic desialylation of native apo-transferrin. Supplemental information for the published paper: Friganović, Tomislav; Tomašić, Antonela; Šeba, Tino; Biruš, Ivan; Kerep, Robert; Borko, Valentina; Šakić, Davor ...
Borko, Valentina, Šeba, Tino, Kerep, Robert, Weitner, Tin, Friganović, Tomislav, Biruš, Ivan   +5 more
core   +1 more source

Microfluidic Platform for Multiparametric Profiling of Fibrin Permeability, Fibrinolysis, and Cell Invasion

Advanced Functional Materials, Volume 36, Issue 37, 7 May 2026.
This paper introduces a single‐channel H‐junction microfluidic assay that profiles fibrin's evolving function in repair and thrombosis by measuring, in one ∼3 µL gel, permeability, fibrinolysis kinetics, fibroblast invasion, and clot extension in real time.
Halston Deal, Elizabeth M. Byrnes, Sanika Pandit, Halle J. Cantor, Muskan Aslam, Stacy Ban, Megan Palmisano, Rosemary Bayless, Ashley C. Brown, Michael Daniele   +9 more
wiley   +1 more source

One‐Step Glycoengineering of NK Cells With High‐Affinity Siglec Ligands for Cancer Immunotherapy

Advanced Science, Volume 13, Issue 26, 8 May 2026.
This study develops an engineered NmCSS enzyme with improved activity for bulky group modified sialic acids, enabling efficient synthesis of structurally diverse sialoside analogs in a single step. Glycan microarray screening identified Siglec high‐affinity ligands, which were incorporated onto natural killer (NK) cells via a one‐pot enzymatic system ...
Shuai Hu, Ben Huang, Lingyan Wang, Qiang Guo, Cuiping Jiang, Ruicheng Qi, Shuyao Wang, Lin‐Tai Da, Wenjie Peng   +8 more
wiley   +1 more source

Metabolism of Interferon: Hepatic Clearance of Native and Desialylated Interferon

Journal of General Virology, 1977
The effect of removal of sialic acid on the survival of rabbit serum and urinary interferon (IF) has been investigated in isolate, perfused rabbit liver preparations. In contrast with native IF, which may be already partially desialylated. IF freed of 80 to 90% of its sialic acid was rapidly cleared from the perfusate of normal livers, or livers pre ...
V, Bocci, A, Pacini, G P, Pessina, V, Bargigli, M, Russi   +4 more
openaire   +2 more sources

Transient desialylation in combination with a novel antithrombin deficiency causing a severe and recurrent thrombosis despite anticoagulation therapy

, 2017
An in-depth focused study of specific cases of patients with recurrent thrombosis may help to identify novel circumstances, genetic and acquired factors contributing to the development of this disorder.
Nuria Revilla, Antonia Miñano, Raquel López-Gálvez, María Luisa Lozano, Dirk J. Lefeber, Mara Toderici, Ángel García-Avello, José Padilla, Javier Corral, Vicente Vicente, María Eugenia de la Morena-Barrio   +10 more
core   +1 more source

Mucin Type Drives Composition and Mucin Glycan Degradation of an In Vitro Synthetic Microbial Community

Environmental Microbiology, Volume 28, Issue 5, May 2026.
The human gut outer mucus layer hosts specific microbes. Using a synthetic mucin glycan‐degrading microbial community to mimic this mucosal microbiome, we show that mucin type affects microbial community composition, glycan degradation and metabolite production.
Maryse D. Berkhout, Carol de Ram, Merlijn P. van Gaal, Henk Schols, Clara Belzer, Caroline M. Plugge   +5 more
wiley   +1 more source

Desialylation and Apoptosis Crosstalk to Modulate Platelet Clearance

Blood, 2019
Our understanding of cell biological processes involved in aging has advance greatly over the past decades. Platelets are small cells that circulate for 4-5 days in mice and 7-10 days in humans. And even though, platelets are anucleated cells, a growing body of evidence shows that platelet clearance is a well-regulated mechanism.
Renata Grozovsky, Cameron Fraser, Karin M. Hoffmeister, Kristopher Sarosiek, Silvia Giannini   +4 more
openaire   +1 more source

Desialylation of Human Cancer Cells Leading Apoptosis by Treatment with Purified and Overexpressed Nani Cloned from Clostridium Perfringens Atcc 10543

, 2008
The effect of NanI, overexpressed nanIgene cloned from Clostridiumperfringens ATCC 10543, on NIH:OVCAR-3 cancer cells and the mediators relaying the apoptosis induced by NanI were investigated.
Tseng, Hui-Chun; Chow, Song-Nan; Huang, Li-Ying; Chien, Chin-Hsiang, 周松男;簡靜香   +1 more
core  

Sialidase Neu3 Induced Sialic Acid Disorder and Promoted Vascular Endothelial Injury Through Transcription Factor SP3

Journal of Cellular and Molecular Medicine, Volume 30, Issue 9, May 2026.
ABSTRACT Atherosclerotic cardiovascular disease is still a major cause for the increasing mortality worldwide. The elevated metabolite N‐acetylneuraminic acid (Neu5Ac) was considered one of the important risk factors responsible for the initiation of endothelial impairment, then participated in atherosclerosis progression.
Yining Lu, Peng Xiang, Qingqiu Chen, Xianmin Wang, Le Chen, Tongchuan Wang, Rong Hu, Limei Ma, Chao Yu   +8 more
wiley   +1 more source