Results 61 to 70 of about 18,623 (291)
Pemphigus IgG Causes Skin Splitting in the Presence of Both Desmoglein 1 and Desmoglein 3 [PDF]
The American Journal of Pathology, 2007 According to the desmoglein (Dsg) compensation concept, different epidermal cleavage planes observed in pemphigus vulgaris and pemphigus foliaceus have been proposed to be caused by different autoantibody profiles against the desmosomal proteins Dsg 1 and Dsg 3.
Volker Spindler +3 more
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Detection of Desmoglein-3 Auto-Antibodies in Patients with Lichen Planus [PDF]
Egyptian Journal of Medical Research, 2022 There is controversy about the role of auto anti-bodies against desmoglein 3 (Dsg 3) in the pathogenesis of lichen planus (LP). The goal of this study is to detect desmoglein-3 auto-antibodies in lichen planus patients comparted to normal control persons
Abd-El Aziz El-Rifaie +3 more
doaj +1 more source
Desmoglein directs differentiation [PDF]
Journal of Cell Biology, 2009 The cell adhesion protein desmoglein 1 (Dsg1) has an extra function in suppressing EGF receptor (EGFR) signaling, helping skin cells differentiate into the different layers of the epidermis, report [Getsios, Simpson, et al.][1] ![Figure][2] Activated EGFR (green) is only found in the ...
openaire +2 more sources
Differential Downregulation of E-Cadherin and Desmoglein by Epidermal Growth Factor
Dermatology Research and Practice, 2012 Modulation of cell : cell junctions is a key event in cutaneous wound repair. In this study we report that activation of the epidermal growth factor (EGF) receptor disrupts cel : cell adhesion, but with different kinetics and fates for the desmosomal ...
Miquella G. Chavez +5 more
doaj +1 more source
Frontiers in Immunology, 2012 The autoimmune regulator (Aire)-directed ectopic expression of tissue-specific antigens (TSAs) by mature medullary thymic epithelial cells (mTECs) has been viewed as an essential mechanism in the induction of central tolerance.
Xiaoping eWang +6 more
doaj +1 more source
Limbal stem cell transplantation: clinical results, limits, and perspectives [PDF]
, 2018 Limbal stem cell deficiency (LSCD) is a clinical condition characterized by damage of cornea limbal stem cells, which results in an impairment of corneal epithelium turnover and in an invasion of the cornea by the conjunctival epithelium.
Bruscolini, Alice +3 more
core +1 more source
Sudden cardiac death in young athletes: Literature review of molecular basis [PDF]
, 2020 Intense athletic training and competition can rarely result in sudden cardiac death (SCD). Despite the introduction of pre-participation cardiovascular screening, especially among young competitive athletes, sport-related SCD remains a debated issue ...
Barbara Lombardo +5 more
core +1 more source
Prognostic Significance of Desmoglein 2 and Desmoglein 3 in Esophageal Squamous Cell Carcinoma [PDF]
Asian Pacific Journal of Cancer Prevention, 2014 Desmogleins (DSGs) are major members among the desmosomal cadherins critically involved in cell-cell adhesion and the maintenance of normal tissue architecture in epithelia. Reports exploring links of DSG family member expression with cancers are few and vary.
Li-Yan Xu +8 more
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Pathophysiology of autoimmune bullous diseases: Nature versus nurture
Indian Journal of Dermatology, 2017 Pemphigus and pemphigoid are the prototypical immunobullous diseases. Although it has been well established that they are caused by deposition of autoreactive antibodies directed against adherence proteins within the skin, the specific genetic and ...
Forum Patel +8 more
doaj +1 more source
Desmoglein as a Target in Skin Disease and Beyond [PDF]
Journal of Investigative Dermatology, 2012 Much of the original research on desmosomes and their biochemical components was through analysis of skin and mucous membranes. The identification of desmogleins 1 and 3, desmosomal adhesion glycoproteins, as targets in pemphigus, a fatal autoimmune blistering disease of the skin and mucous membranes, provided the first link between desmosomes ...
Masayuki Amagai, John R. Stanley
openaire +3 more sources