Results 81 to 90 of about 18,623 (291)

Functional differences between two morphologically distinct cell subpopulations within a human colorectal carcinoma cell line

Brazilian Journal of Medical and Biological Research, 2001
The LISP-I human colorectal adenocarcinoma cell line was isolated from a hepatic metastasis at the Ludwig Institute, São Paulo, SP, Brazil. The objective of the present study was to isolate morphologically different subpopulations within the LISP-I cell ...
A.C.C. Solimene, C.R.W. Carneiro, I. Melati, J.D. Lopes   +3 more
doaj   +1 more source

Mouse models of pemphigus: valuable tools to investigate pathomechanisms and novel therapeutic interventions

Frontiers in Immunology, 2023
Autoimmune blistering diseases (AIBD) are paradigms of autoantibody-mediated organ-specific autoimmune disorders that involve skin and/or mucous membranes.
Shirin Emtenani, Shirin Emtenani, Michael Hertl, Enno Schmidt, Enno Schmidt, Christoph Hudemann   +5 more
doaj   +1 more source

Characterization of Desmoglein-3 Epitope Region Peptides as Synthetic Antigens: Analysis of their in vitro T-cell Stimulating Efficacy, Cytotoxicity, Stability and their Conformational Features [PDF]

, 2015
Desmoglein-3 (Dsg3) adhesion protein is the main target of autoantibodies and autoreactive T cells in Pemphigus vulgaris (PV) autoimmune skin disorder.
Ahmed, Ahmed, Amagai, Amagai, Amber, Anhalt, Berkower, Carmicle, Chou, Delva, Dworschak, Enyedi, Estaquier, Ferrante, Green, Gómara, Hashimoto, Hertl, Holly, Hollósi, Jurcevic, Lin, Mahoney, Manning, Meager, Moesta, Mosmann, Partidos, Povey, Rammensee, Riechers, Ruocco, Sathyanarayana, Scharf, Scharf, Schiltz, Shanmugam, Siddiqui, Siligardi, Slater, Stanley, Sz, Szabados, Thomason, Toniolo, Vass, Veldman, Watts, Wheeler, Woody, Woody, Wucherpfennig, Wucherpfennig, Yang   +53 more
core   +1 more source

Desmoglein-3

Definitions, 2020
Desmoglein-3 (999 aa, ~108 kDa) is encoded by the human DSG3 gene. This protein plays a role in desmosome-mediated cell-cell adhesion.

semanticscholar   +1 more source

T Regulatory Cell-Associated Tolerance Induction by High-Dose Immunoglobulins in an HLA-Transgenic Mouse Model of Pemphigus

Cells, 2023
Pemphigus vulgaris (PV) is a potentially lethal autoimmune bullous skin disorder caused by IgG autoantibodies against desmoglein 3 (Dsg3) and Dsg1. During the last three decades, high-dose intravenous immunoglobulins (IVIgs) have been applied as an ...
Christoph Hudemann, Jochen Hoffmann, Enno Schmidt, Michael Hertl, Rüdiger Eming   +4 more
doaj   +1 more source

The cell-cell junctions of mammalian testes: I. The adhering junctions of the seminiferous epithelium represent special differentiation structures [PDF]

, 2014
The seminiferous tubules and the excurrent ducts of the mammalian testis are physiologically separated from the mesenchymal tissues and the blood and lymph system by a special structural barrier to paracellular translocations of molecules and particles ...
Domke, Lisa M., Dörflinger, Yvette, Franke, Werner W., Heid, Hans, Kuhn, Caecilia, Rickelt, Steffen, Rosin-Arbesfeld, Rina, Winter-Simanowski, Stefanie, Zimbelmann, Ralf   +8 more
core   +2 more sources

Desmogleins: Hair perspective

International Journal of Trichology, 2013
Desmogleins (Dsgs) are calcium-dependent, transmembrane glycoproteins belonging to the desmosomal cadherin superfamily, which play significant roles in selective calcium ions (Ca(2+)) dependent adhesion interactions between cell surfaces. Four subtypes of Dsg have been identified.
openaire   +3 more sources

Significance of epitope spreading in the pathogenesis of pemphigus vulgaris and foliaceus [PDF]

, 2008
Os pênfigos são dermatoses bolhosas auto-imunes, em que há a produção de auto-anticorpos direcionados contra moléculas de adesão dos epitélios, levando à perda da coesão celular.
AOKI, Valéria, LAGO, Fernanda, MARUTA, Celina Wakisaka, SANTI, Cláudia Giuli, The Cooperative Group on Fogo Selvagem Research, YAMAZAKI, Márcia Harumi   +5 more
core   +2 more sources

High risk of heart failure associated with desmoglein‐2 mutations compared to plakophilin‐2 mutations in arrhythmogenic right ventricular cardiomyopathy/dysplasia

European Journal of Heart Failure, 2019
Previous studies suggested that genetic status affects the clinical course of arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D) patients.
A. Hermida, V. Fressart, F. Hidden‐Lucet, E. Donal, V. Probst, J. Deharo, P. Chevalier, D. Klug, N. Mansencal, E. Delacrétaz, P. Cosnay, P. Scanu, F. Extramiana, D. Keller, S. Rouanet, P. Charron, E. Gandjbakhch   +16 more
semanticscholar   +1 more source

Role of Dsg1- and Dsg3-Mediated Signaling in Pemphigus Autoantibody-Induced Loss of Keratinocyte Cohesion

Frontiers in Immunology, 2019
Pemphigus is an autoimmune dermatosis in which mucocutaneous blisters are induced primarily by autoantibodies against Desmoglein (Dsg) 1 and 3. Pemphigus vulgaris (PV) usually is associated with autoantibodies against Dsg3 whereas pemphigus foliaceus (PF)
Elias Walter, Franziska Vielmuth, Marie-Therès Wanuske, Matthias Seifert, Robert Pollmann, Rüdiger Eming, Jens Waschke   +6 more
doaj   +1 more source