Results 131 to 140 of about 16,279,763 (246)
Autoimmunity, 2006 Pemphigus vulgaris is an autoimmune blistering disease characterized by cell-cell detachment of epidermal cells. Autoantibody against desmoglein (Dsg) 3, a transmembrane glycoprotein that mediates the association of desmosomes, plays a major role in blistering in pemphigus vulgaris (PV). The mechanisms of autoantibody-induced acantholysis have not been
Yumi Aoyama +4 more
openaire +3 more sources
Comparative Transcriptome Analysis Identifies Desmoglein-3 as a Potential Oncogene in Oral Cancer Cells. [PDF]
Cells, 2023 Wan H, Teh MT, Mastroianni G, Ahmad US.
europepmc +1 more source
PLoS ONE, 2016 Pemphigus vulgaris (PV) is characterized by IgG1 and IgG4 autoantibodies to desmoglein (Dsg) 3, causing suprabasal blistering of skin and mucous membranes.
Agnes Lo +7 more
semanticscholar +1 more source
The disease mutation A77V in Ryanodine receptor RyR2 induces changes in energy conduction pathways in the protein [PDF]
, 2011 Energetically responsive residues of the 217 amino acid N-terminal domain of the cardiac Ryanodine receptor RyR2 are identified by a simple elastic net model. These residues lie along a hydrogen bonded path through the protein.
Burak Erman, Nazan Walpoth
core +1 more source
New insights into desmosome regulation and pemphigus blistering as a desmosome-remodeling disease
Kaohsiung Journal of Medical Sciences, 2013 Desmosomes in keratinocytes are the most important intercellular adhering junctions that provide structural strength for the epidermis. These junctions are connected directly with desmosomal cadherin proteins.
Yasuo Kitajima
doaj +1 more source
Molecular Oncology, Volume 19, Issue S1, Page 1-895, June 2025.Abstracts submitted to the ‘EACR 2025 Congress: Innovative Cancer Science’, from 16–19 June 2025 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley +1 more source
Desmoglein 3, via an Interaction with E-cadherin, Is Associated with Activation of Src
PLoS ONE, 2010 Desmoglein 3 (Dsg3), a desmosomal adhesion protein, is expressed in basal and immediate suprabasal layers of skin and across the entire stratified squamous epithelium of oral mucosa. However, increasing evidence suggests that the role of Dsg3 may involve more than just cell-cell adhesion.To determine possible additional roles of Dsg3 during epithelial ...
Hong Wan +9 more
openaire +6 more sources
Orphanet Journal of Rare Diseases, 2012 Background Various antigen-specific immunoassays are available for the serological diagnosis of autoimmune bullous diseases. However, a spectrum of different tissue-based and monovalent antigen-specific assays is required to establish the diagnosis ...
van Beek Nina +9 more
doaj +1 more source
Attenuation of OX40 signaling suppression by age disrupts peripheral deletion of CD4+ T cells specific for the epidermal autoantigen desmoglein 3. [PDF]
Immun Ageing, 2023 Iriki H +6 more
europepmc +1 more source
Immunity to self co-generates regulatory T cells [PDF]
, 2008 Immune responses to self are kept in check by tolerance mechanisms, including suppression by regulatory T cells (Tregs). The defective generation of Tregs specific for self-antigens may lead to autoimmune disease.
Bo Han Lee +8 more
core +1 more source