Results 131 to 140 of about 7,257 (168)

Autoantibodies to desmogleins 1 and 3 in patients with lichen planus

Archives of Dermatological Research, 2017
There is controversy about the role of autoantibodies against desmoglein 1 and 3 (Dsg1 and 3) in the pathogenesis of lichen planus (LP); the authors planned this study to determine the presence of circulating levels of these antibodies in patients with different types of oral LP and to compare that with cutaneous LP and healthy controls.
Lajevardi, Vahide, Halaji, Zahra, Ghaedi, Forugh, Saljoughi, Nazi   +3 more
openaire   +2 more sources

Oral lichen planus with antibodies to desmogleins 1 and 3

The Journal of Dermatology, 2014
AbstractLichen planus (LP) is a chronic inflammatory disorder involving the skin or mucous membranes. Previous studies have demonstrated that some LP patients showed positive enzyme‐linked immunosorbent assay (ELISA) for desmoglein (DSG) antibodies. We report a case with intractable painful oral lesions.
Chihiro, Kinjyo, Takahide, Kaneko, Ayumi, Korekawa, Akiko, Rokunohe, Takayuki, Aizu, Yasushi, Matsuzaki, Hajime, Nakano, Daisuke, Sawamura   +7 more
openaire   +2 more sources

ELISA detection of anti‐desmoglein 1 and anti‐desmoglein 3 and indirect immunofluorescence in oral pemphigus: A retrospective study

Oral Diseases, 2021
Abstract Objective The aim of this study was to test the efficacy of autoantibodies to desmoglein 1 and desmoglein 3 detected by ELISA and indirect immunofluorescence in the diagnosis of oral pemphigus and to correlate the antibody titres with the severity of the disease.
Massimo Petruzzi, Alberta Lucchese, Maria Contaldo, Marilina Tampoia, Maria Antonia Frassanito, Dorina Lauritano, Fedora della Vella   +6 more
openaire   +4 more sources

Plakophilin 1 but not plakophilin 3 regulates desmoglein clustering

Cellular and Molecular Life Sciences, 2019
Plakophilins (Pkp) are desmosomal plaque proteins crucial for desmosomal adhesion and participate in the regulation of desmosomal turnover and signaling. However, direct evidence that Pkps regulate clustering and molecular binding properties of desmosomal cadherins is missing. Here, keratinocytes lacking either Pkp1 or 3 in comparison to wild type (wt)
Fuchs M, Foresti M, Radeva MY, Kugelmann D, Keil R, Hatzfeld M, Spindler V, Waschke J, Vielmuth F   +8 more
openaire   +3 more sources

Pathogenic human monoclonal antibody against desmoglein 3

Clinical Immunology, 2006
Pemphigus vulgaris (PV) is a potentially fatal autoimmune mucocutaneous disease associated with production of IgG autoantibodies to desmoglein 3 (Dsg3), a 130-kDa epidermal cadherin protein. The binding of pathogenic antibody to Dsg3 on epidermal keratinocytes leads to loss of intercellular adhesion and results in intraepithelial blister formation ...
Shih-Wei, Yeh, Lisa A, Cavacini, Kailash C, Bhol, Mong-Shang, Lin, Mukesh, Kumar, Mark, Duval, Marshall R, Posner, A Razzaque, Ahmed   +7 more
openaire   +2 more sources

Protection against Pemphigus Foliaceus by Desmoglein 3 in Neonates

New England Journal of Medicine, 2000
Pemphigus foliaceus is an autoantibody-mediated blistering disease in which antibodies against desmoglein 1 cause loss of adhesion among keratinocytes in the superficial epidermis.1 Desmogleins are transmembrane glycoproteins found in desmosomes, which provide physical connections between cells.
H, Wu, Z H, Wang, A, Yan, S, Lyle, S, Fakharzadeh, J K, Wahl, M J, Wheelock, H, Ishikawa, J, Uitto, M, Amagai, J R, Stanley   +10 more
openaire   +2 more sources

Anti‐Desmoglein 3 Avidity Correlates Better With Pemphigus Vulgaris Severity Than Anti‐Desmoglein 3 Concentration

International Journal of Dermatology
ABSTRACT Background Pemphigus vulgaris (PV) is caused by immunoglobulin G (IgG) autoantibodies targeting desmoglein 3 (Dsg3) and/or desmoglein 1 (Dsg1). While antibody concentration is routinely used to assess disease activity, the role of antibody avidity in PV monitoring has not been ...
Branislav Lekic, Branka Bonaci‐Nikolic, Jovan Lalosevic, Dragana Jovanovic, Dubravka Zivanovic, Milos Nikolic   +5 more
openaire   +2 more sources

AUTOANTIBODIES TO DESMOGLEIN‑3 IN PATIENTS WITH ACANTHOLYTIC PEMPHIGUS

Dermatology and Venerology
Introduction. Current data on the pathogenesis of acantholytic pemphigus emphasize the important role of desmoglein 3 (Dsg 3) in the initiation of the autoimmune process and the formation of the clinical phenotype of the disease. The aim is to determine the level of circulating antibodies to Dsg3 in patients with different clinical forms of pemphigus ...
Kutasevych Ya.F., Dzhoraeva S.K., Oliinyk I.O., Mashtakova I.O., Kondakova H.K., Kurylo N.B.   +5 more
openaire   +1 more source

Desmoglein 3 and 1 in desquamative gingivitis

2003
Evaluation of dsg 3 and 1 autoantibodies may play an important role in the desquamative gingivitis.
Brozović-Sistig, Suzana, Cekić-Arambašin, Ana, Lukač, Josip, Vučićević Boras, Vanja   +3 more
openaire   +1 more source

Desmoglein 1 and desmoglein 3 as autoimmune target of herpetiform pemphigus

Journal of Dermatological Science, 1998
Ken Ishii, Masayuki Amagai, Ayako Komai, Tamotsu Ebihara, Tadeusz P. Chorzelski, Takeji Nishikawa, Takashi Hashimoto   +6 more
openaire   +1 more source