Results 61 to 70 of about 4,329 (200)

A Cluster of Three snoRNAs Including Jouvence Required in the Gut Determines Lifespan and Confers Neuroprotection Through Metabolic Parameters

Aging Cell, Volume 25, Issue 4, April 2026.
The disruption of a cluster of three snoRNAs in the epithelium of the gut deregulates the lipid and sterol (including the cholesterol) homeostasis. At the whole‐organism level, this chronic deregulation, all along life, decreases lifespan and leads to neurodegenerative lesions in old flies.
Sara Al Issa, Théo Gauvrit, Patricia Daira, Nathalie Bernoud‐Hubac, Jean‐René Martin   +4 more
wiley   +1 more source

A highly sensitive method for analysis of 7-dehydrocholesterol for the study of Smith-Lemli-Opitz syndrome[S]

Journal of Lipid Research, 2014
We describe a highly sensitive method for the detection of 7-dehydrocholesterol (7-DHC), the biosynthetic precursor of cholesterol, based on its reactivity with 4-phenyl-1,2,4-triazoline-3,5-dione (PTAD) in a Diels-Alder cycloaddition reaction.
Wei Liu, Libin Xu, Connor Lamberson, Dorothea Haas, Zeljka Korade, Ned A. Porter   +5 more
doaj   +1 more source

Sterols associated with small unilamellar vesicles (SUVs): intrinsic mobility role for 1H NMR detection.

, 2014
International audienceSmall unilamellar vesicles (SUVs) of phospholipids are often used as a membrane model system for studying the interaction of molecules.
Bondon, Arnaud, Da Costa, Grégory, Mouret, Liza   +2 more
core   +3 more sources

Cholesterol Deficiency Directs Autophagy‐Dependent Secretion of Extracellular Vesicles

Journal of Extracellular Vesicles, Volume 15, Issue 1, January 2026.
Inhibition of cholesterol biosynthesis within models of rare disease and cancer causes increased release of small extracellular vesicles (sEVs) with distinct biological properties. Mechanistically, cholesterol depletion leads to impaired autophagic flux, redirection of autophagosomes to late endosomes, and subsequently increased sEV secretion ...
Jazmine D. W. Yaeger, Sonali Sengupta, Austin L. Walz, Mayu Morita, Terry K. Morgan, Paola D. Vermeer, Kevin R. Francis   +6 more
wiley   +1 more source

Serum squalene and noncholesterol sterols before and after delivery in normal and cholestatic pregnancy

Journal of Lipid Research, 1996
Mechanisms of hyperlipidemia were studied by measurement of serum lipid concentrations and the ratios of cholesterol precursors (squalene, delta 8-cholestenol, desmosterol, and lathosterol), plant sterols (campesterol and sitosterol), and cholestanol (a ...
K Nikkilä, S Riikonen, M Lindfors, T A Miettinen   +3 more
doaj   +1 more source

The effect of hydroxychloroquine on cholesterol metabolism in statin treated patients after myocardial infarction

Atherosclerosis Plus, 2023
Background and aims: To evaluate the effect of hydroxychloroquine (HCQ) on serum and lipoprotein lipids and serum biomarkers of cholesterol synthesis and absorption in myocardial infarction patients with a high-dose statin. Methods: Myocardial infarction
Lotta Ulander, Piia Simonen, Heli Tolppanen, Otto Hartman, Tuomas T. Rissanen, Kari K. Eklund, Marita Kalaoja, Mika Kurkela, Mikko Neuvonen, Mikko Niemi, Janne T. Backman, Helena Gylling, Juha Sinisalo   +12 more
doaj   +1 more source

The ecdysteroidome of Drosophila: influence of diet and development [PDF]

, 2015
Ecdysteroids are the hormones regulating development, physiology and fertility in arthropods, which synthesize them exclusively from dietary sterols. But how dietary sterol diversity influences the ecdysteroid profile, how animals ensure the production ...
Carvalho, M., Dye, N. A., Eaton, S., Lafont, R., Lavrynenko, O., Rodenfels, J., Shevchenko, A.   +6 more
core   +4 more sources

Sterol Metabolism in Ovariectomized Rats: Potential Roles of Campesterol and 4β‐Hydroxycholesterol in Osteoporosis

Lipids, Volume 61, Issue 1, Page 151-162, January 2026.
ABSTRACT Osteoporosis is characterized by low bone mass and microarchitectural deterioration of bone tissue. Lipid metabolism disorders may contribute to osteoporosis in postmenopausal women. Phytosterols and oxysterols (OC) are involved in lipid metabolism.
Wenzhao He, Sayuri Eguchi, Sen Wang, Yasutake Tanaka, Masao Sato   +4 more
wiley   +1 more source

Desmosterol and 7-dehydrocholesterol concentrations in post mortem brains of depressed people: The role of trazodone

Translational Psychiatry, 2022
Major depressive disorder (MDD) is a common, disabling, and heterogeneous condition that responds unpredictably to current treatments. We previously showed an association between depressive symptoms and plasma concentrations of two cholesterol precursors,
Basar Cenik, Jayme M. Palka, Bonne M. Thompson, Jeffrey G. McDonald, Carol A. Tamminga, Can Cenik, E. Sherwood Brown   +6 more
doaj   +1 more source

RETRACTED ARTICLE: Age-dependent Increase in Desmosterol Restores DRM Formation and Membrane-related Functions in Cholesterol-free DHCR24−/− Mice [PDF]

, 2018
Cholesterol is a prominent modulator of the integrity and functional activity of physiological membranes and the most abundant sterol in the mammalian brain. DHCR24-knock-out mice lack cholesterol and accumulate desmosterol with age.
Crameri, Arames, Heppner, Frank, Kalvodova, Lucie, Kuehnle, Katrin, Kulic, Luka, Ledesma, Maria, Lütjohann, Dieter, Mohajeri, M., Nitsch, Roger, Skaanes-Brunner, Fabienne, Smith, Alicia, Thelen, Karin   +11 more
core