Results 121 to 130 of about 1,974 (174)

Synthesis of (±)‐Merrilactone A by a Desymmetrization Strategy

Chemistry – A European Journal, 2018
AbstractA concise synthesis of (±)‐merrilactone A has been accomplished featuring desymmetrization of a Cs‐symmetric dilactone, RhI‐catalyzed intramolecular hydroacylation of a 4‐alkynal, and TiIII‐mediated reductive radical cyclization of epoxy‐allene.
Wentan Liu, Bo Wang
openaire   +2 more sources

Desymmetrization of myo-inositol

Carbohydrate Research
Chemistry and biology of phosphoinositols have been intensely investigated areas of research over the last 4-5 decades due to their involvement in cellular signal transduction pathways. Efficient laboratory synthesis of enantiomeric derivatives of inositols was a central issue since they were required for the delineation of the myo-inositol cycle as ...
Nivedita T, Patil, Madhuri T, Patil, Rajesh G, Gonnade, Mysore S, Shashidhar   +3 more
openaire   +2 more sources

Enantioselective Desymmetrization of Cyclopropenes by Hydroacylation

Journal of the American Chemical Society, 2010
We report an enantioselective desymmetrization of cyclopropenes by intermolecular Rh-catalyzed hydroacylation. Cyclopropylketones, bearing quaternary stereocenters, are produced with diastereocontrol (up to >20:1) and excellent enantiomeric excess (up to >99 ee).
Diem H T, Phan, Kevin G M, Kou, Vy M, Dong   +2 more
openaire   +2 more sources

Catalytic Desymmetric Dicarbofunctionalization of Unactivated Alkenes

Angewandte Chemie, 2022
AbstractThe construction of multi‐stereocenters by a transition metal‐catalyzed cross‐coupling reaction is a major challenge. The catalytic desymmetric functionalization of unactivated alkenes remains largely unexplored. Herein, we disclose ‐a desymmetric dicarbofunctionalization of 1,6‐dienes via a nickel‐catalyzed reductive cross‐coupling reaction ...
Xianqing Wu, Baixue Luan, Wenyu Zhao, Feng He, Xin‐Yan Wu, Jingping Qu, Yifeng Chen   +6 more
openaire   +2 more sources

Desymmetric Partial Reduction of Malonic Esters

Journal of the American Chemical Society, 2022
Desymmetrization of easily available disubstituted malonic esters is a rewarding strategy to access structurally diverse quaternary stereocenters. Particularly, asymmetric reduction of malonic esters would generate a functional group with a lower oxidation state than the remaining ester, thus allowing for more chemoselective derivatization.
Pengwei Xu, Shihao Liu, Zhongxing Huang
openaire   +2 more sources

Desymmetrization and degree of chirality

Journal of Mathematical Chemistry, 1991
Chiral objects, viewed as distorted derivatives of achiral ones, may be represented by points in a configuration space that is spanned by a set of symmetry coordinates derived for the symmetry group of the achiral object of highest symmetry. We propose a measure (d) that quantifies the displacement of the representative point for a chiral object away ...
Thomas P. E. Auf der heyde, Andrzej B. Buda, Kurt Mislow   +2 more
openaire   +1 more source

Enantioselective Desymmetrization of Diynes

European Journal of Organic Chemistry
In the field of asymmetric synthesis, the desymmetrization of prochiral diynes has arisen as a challenging yet effective strategy for the rapid and efficient construction of structurally diverse and complex molecules. This review explores the various methodologies (cycloadditions, cycloisomerizations, and C‐ and X‐ additions) that enable the ...
Anne Boussonnière, Kim Uyen Ly, Anne‐Sophie Castanet   +2 more
openaire   +1 more source

Catalytic Enantioselective Intermolecular Desymmetrization of Azetidines

Journal of the American Chemical Society, 2015
The first catalytic asymmetric desymmetrization of azetidines is disclosed. Despite the low propensity of azetidine ring opening and challenging stereocontrol, smooth intermolecular reactions were realized with excellent efficiency and enantioselectivity.
Wang, Zhaobin, Sheong, Fu Kit, Sung, Ho Yung, Williams, Ian Duncan, Lin, Zhenyang, Sun, Jianwei   +5 more
openaire   +3 more sources

Desymmetrization of OD Structures

Kristall und Technik, 1979
AbstractIt has been shown that the symmetry and structure of individual OD layers may depend on their actual stacking in a (polytypic) OD structure, leading to significant deviations from the ideal OD symmetry. This phenomenon has been called “desymmetrization of OD structures”; its significance for polytypism and for crystallochemistry is discussed.
openaire   +1 more source

Desymmetrization of 4,6-diprotected myo-inositol

Chemical Communications, 2013
The asymmetric desymmetrization of 4,6-diprotected myo-inositol derivatives was achieved by using a bifunctional, readily available nucleophilic catalyst. The orthogonally protected products were obtained in 80-99% yield with 90-99% ee. Such structures serve as potential enantiopure building blocks for the synthesis of myo-inositol phosphates.
Markus B, Lauber, Constantin-Gabriel, Daniliuc, Jan, Paradies   +2 more
openaire   +2 more sources