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Enantioselective Desymmetrization of Tropinone Derivatives by Hydroboration
Synlett, 2003N-Protected tropenone derivs. I (R = CO2Me, CBZ, Ts) prepd. from the resp. pyrroles and tetrabromoacetone, were used as starting materials for desymmetrization by hydroboration of the C-C double bond. Hydroboration of I with (-)-(Ipc)2BH followed by oxidn., however, gave the desired 6-hydroxylated product only in low yield due to byproduct formation ...
Cramer, Nicolai +3 more
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Enantioselective Desymmetrization of Cyclobutanones: A Speedway to Molecular Complexity
Angewandte Chemie - International Edition, 2020Johannes M Wahl, Jan Sietmann
exaly

