Results 111 to 120 of about 27,265 (285)

How are MCPIP1 and cytokines mutually regulated in cancer-related immunity?

Protein & Cell, 2020
Cytokines are secreted by various cell types and act as critical mediators in many physiological processes, including immune response and tumor progression. Cytokines production is precisely and timely regulated by multiple mechanisms at different levels,
Ruyi Xu, Yi Li, Yang Liu, Jianwei Qu, Wen Cao, Enfan Zhang, Jingsong He, Zhen Cai   +7 more
doaj   +1 more source

Assembly and structure of Lys³³-linked polyubiquitin reveals distinct conformations [PDF]

, 2015
Ubiquitylation regulates a multitude of biological processes and this versatility stems from the ability of ubiquitin (Ub) to form topologically different polymers of eight different linkage types. Whereas some linkages have been studied in detail, other
Al-Hakim, Bremm, Chastagner, Chau, Cook, David G Campbell, Deshaies, Emmerich, Fushman, Haglund, Hirano, Hospenthal, Huang, Husnjak, Ikeda, Kar, Kee, Kim, Komander, Kulathu, Kulathu, Lai, Lange, Licchesi, Maria Stella Ritorto, Maspero, Matsumoto, Meyer, Nicholas A Morrice, Peterson, Pickart, Rachel Toth, Reyes-Turcu, Ritorto, Rohaim, Sheng, Soo-Youn Choi, Spratt, Stieglitz, Syed Arif Abdul Rehman, Tran, Varadan, Vijay-Kumar, Virdee, Xu, Yogesh Kulathu, Yosua Adi Kristariyanto, You, Yuan   +48 more
core   +2 more sources

Single‐Cell Atlas of Subchondral Bone Marrow Lesions Reveals Proteostasis Dysfunction as a Druggable Mechanism for Early Osteoarthritis

Advanced Science, EarlyView.
This study reveals that abnormal mechanical stress downregulates the expression of HSP70 and impairs proteasome function in osteoarthritic bone cells, leading to misfolded collagen I accumulation and ER stress. When intracellular proteostasis capacity is exceeded, USP19 mediates the secretion of misfolded proteins into the extracellular space ...
Hailun Xu, Ting He, Yu Qian, Jia Li, Bowei Ni, Xiaojie Xu, Huanbo Wang, Peng Wang, Guoqing Cao, Siqi Ying, Guangyu Ding, Rong Wang, Zenghui Gu, Wei Li, Zhentao Man, Houfeng Zheng, Zhaohua Zhu, Zhen Li, Qingjun Meng, Chao Zheng, Liu Yang   +20 more
wiley   +1 more source

An apicoplast-localized deubiquitinase contributes to the cell growth and apicoplast homeostasis of Toxoplasma gondii

Veterinary Research
Toxoplasma gondii is among the most important parasites worldwide. The apicoplast is a unique organelle shared by all Apicomplexan protozoa.
Jie Xia, Yimin Yang, Xueqiu Chen, Kaiyue Song, Guangxu Ma, Yi Yang, Chaoqun Yao, Aifang Du   +7 more
doaj   +1 more source

Ablation of an Ovarian Tumor Family Deubiquitinase Exposes the Underlying Regulation Governing the Plasticity of Cell Cycle Progression in Toxoplasma gondii

mBio, 2017
The Toxoplasma genome encodes the capacity for distinct architectures underlying cell cycle progression in a life cycle stage-dependent manner. Replication in intermediate hosts occurs by endodyogeny, whereas a hybrid of schizogony and endopolygeny ...
Animesh Dhara, Rodrigo de Paula Baptista, Jessica C. Kissinger, E. Charles Snow, Anthony P. Sinai   +4 more
doaj   +1 more source

Intermittent hypoxia-induced downregulation of microRNA-320b promotes lung cancer tumorigenesis by increasing CDT1 via USP37

Molecular Therapy: Nucleic Acids, 2021
Obstructive sleep apnea-hypopnea (OSAH) is correlated with an increased incidence of lung cancer. In our study, we explored the functional roles of microRNAs (miRNAs) in lung cancer patients that were complicated with OSAH involving the deubiquitination ...
Weihao Li, Kai Huang, Fengbiao Wen, Guanghui Cui, Haizhou Guo, Zhanfeng He, Song Zhao   +6 more
doaj   +1 more source

Dynamic regulation of dynein localization revealed by small molecule inhibitors of ubiquitination enzymes [PDF]

, 2019
Cytoplasmic dynein is a minus-end-directed microtubule-based motor that acts at diverse subcellular sites. During mitosis, dynein localizes simultaneously to the mitotic spindle, spindle poles, kinetochores and the cell cortex.
Cheeseman, Iain M, Monda, Julie Kathryn
core   +1 more source

Structural basis for specific inhibition of the deubiquitinase UCHL1

Nature Communications, 2022
Ubiquitination regulates protein homeostasis and is tightly controlled by deubiquitinases (DUBs). Loss of the DUB UCHL1 leads to neurodegeneration, and its dysregulation promotes cancer metastasis and invasiveness.
Christian Grethe, Mirko Schmidt, Gian-Marvin Kipka, Rachel O’Dea, Kai Gallant, P. Janning, M. Gersch   +6 more
semanticscholar   +1 more source

Antagonistic Ubiquitin Switching by USP7 and RNF40 Orchestrates KDM6A Homeostasis to License Coronavirus Susceptibility

Advanced Science, EarlyView.
We identify an antagonistic ubiquitin circuit that controls cellular permissiveness to multiple coronaviruses. The deubiquitinase USP7 stabilizes the epigenetic regulator KDM6A to upregulate viral receptors, while the E3 ligase RNF40 degrades KDM6A by catalyzing K6/K11‐ubiquitin chains of KDM6A for autophagic degradation.
Meng‐Zhuo Huang, Zhong‐Yuan Yang, Shi Wang, Yan Ge, Lan Lin, Mia Madel Alfajaro, Renata B. Filler, Wan‐Yao Song, Ming‐Zhu Kong, Jin Wei   +9 more
wiley   +1 more source

Deubiquitinase JOSD1 tempers hepatic proteotoxicity

Cell Death Discovery
ABSTRACTDerangements in protein homeostasis and associated proteotoxicity mark acute, chronic, and drug-induced hepatocellular injury. Metabolic dysfunction-associated proteasomal inhibition and the use of proteasome inhibitors often underlie such pathological hepatic proteotoxicity.
Saheli Chowdhury, Abhishek Sen, Debajyoti Das, Partha Chakrabarti   +3 more
openaire   +3 more sources