Results 41 to 50 of about 27,265 (285)

Deubiquitinases in cancer

Oncotarget, 2015
Deubiquitinases are deubiquitinating enzymes (DUBs), which remove ubiquitin from proteins, thus regulating their proteasomal degradation, localization and activity. Here, we discuss DUBs as anti-cancer drug targets.
Rongbin, Wei, Xiaodong, Liu, Weixin, Yu, Tianshu, Yang, Wenping, Cai, Junjun, Liu, Xiao, Huang, Guo-tong, Xu, Shouliang, Zhao, Jianhua, Yang, Shangfeng, Liu   +10 more
openaire   +3 more sources

USP15 regulates dynamic protein-protein interactions of the spliceosome through deubiquitination of PRP31. [PDF]

, 2017
Post-translational modifications contribute to the spliceosome dynamics by facilitating the physical rearrangements of the spliceosome. Here, we report USP15, a deubiquitinating enzyme, as a regulator of protein-protein interactions for the spliceosome ...
Das, Tanuza, Kim, Eunice EunKyeong, Kim, Eunji, Park, Jinyoung, Park, Joon Kyu, Rape, Michael, Song, Eun Joo   +6 more
core   +1 more source

The A-MYSM Power of Deubiquitinases [PDF]

Immunity, 2011
Little is known about the developmental functions of chromatin regulators that can deubiquitinate histones. In this issue of Immunity, Jiang et al. (2011) demonstrate that the deubiquitinase MYSM1 is part of an epigenetic switch that turns on B cell development.
Demarco, Ignacio A., Singh, Harinder
openaire   +2 more sources

Three-Dimensional Architecture of the Human BRCA1-A Histone Deubiquitinase Core Complex

Cell Reports, 2016
BRCA1 is a tumor suppressor found to be mutated in hereditary breast and ovarian cancer and plays key roles in the maintenance of genomic stability by homologous recombination repair.
Otto J.P. Kyrieleis, Pauline B. McIntosh, Sarah R. Webb, Lesley J. Calder, Janette Lloyd, Nisha A. Patel, Stephen R. Martin, Carol V. Robinson, Peter B. Rosenthal, Stephen J. Smerdon   +9 more
doaj   +1 more source

USP38 Inhibits Zika Virus Infection by Removing Envelope Protein Ubiquitination

Viruses, 2021
Zika virus (ZIKV) is a mosquito-borne flavivirus, and its infection may cause severe neurodegenerative diseases. The outbreak of ZIKV in 2015 in South America has caused severe human congenital and neurologic disorders.
Yingchong Wang, Qin Li, Dingwen Hu, Daolong Gao, Wenbiao Wang, Kailang Wu, Jianguo Wu   +6 more
doaj   +1 more source

Protein import into the endosymbiotic organelles of apicomplexan parasites [PDF]

, 2018
The organelles of endosymbiotic origin, plastids, and mitochondria, evolved through the serial acquisition of endosymbionts by a host cell. These events were accompanied by gene transfer from the symbionts to the host, resulting in most of the organellar
Fellows, Justin, Johnson, Carla, Mallo, Natalia, Sheiner, Lilach   +3 more
core   +1 more source

Deubiquitinase USP35 modulates ferroptosis in lung cancer via targeting ferroportin

Clinical and Translational Medicine, 2021
Background Ferroptosis is essential to regulate tumor growth and serves as a promising therapeutic target to lung cancer. Ubiquitin‐specific protease 35 (USP35) belongs to the deubiquitinases family that is associated with cell proliferation and mitosis.
Zheng Tang, Wanli Jiang, Ming Mao, Jinping Zhao, Jiakuan Chen, Nitao Cheng   +5 more
semanticscholar   +1 more source

Ubiquitination accomplished: E1 and E2 enzymes were not necessary [PDF]

, 2016
Qiu et al. (2016) show that a mono-ADP-ribosyltransferase, SdeA, from Legionella pneumophila catalyzes ADP-ribosylation of ubiquitin, allowing SdeA to modify substrate with ubiquitin in the absence of E1 and E2 ...
Huang, Danny T., Nakasone, Mark
core   +1 more source

OTUD1 deubiquitinase regulates NF-κB- and KEAP1-mediated inflammatory responses and reactive oxygen species-associated cell death pathways

Cell Death and Disease, 2022
Deubiquitinating enzymes (DUBs) regulate numerous cellular functions by removing ubiquitin modifications. We examined the effects of 88 human DUBs on linear ubiquitin chain assembly complex (LUBAC)-induced NF-κB activation, and identified OTUD1 as a ...
D. Oikawa, M. Gi, H. Kosako, K. Shimizu, Hirotaka Takahashi, Masayuki Shiota, S. Hosomi, Keidai Komakura, H. Wanibuchi, D. Tsuruta, T. Sawasaki, F. Tokunaga   +11 more
semanticscholar   +1 more source

Regulation of CYLD activity and specificity by phosphorylation and ubiquitin-binding CAP-Gly domains

Cell Reports, 2021
Summary: Non-degradative ubiquitin chains and phosphorylation events govern signaling responses by innate immune receptors. The deubiquitinase CYLD in complex with SPATA2 is recruited to receptor signaling complexes by the ubiquitin ligase LUBAC and ...
Paul R. Elliott, Derek Leske, Jane Wagstaff, Lisa Schlicher, Georgina Berridge, Sarah Maslen, Frederik Timmermann, Biao Ma, Roman Fischer, Stefan M.V. Freund, David Komander, Mads Gyrd-Hansen   +11 more
doaj   +1 more source