Results 121 to 130 of about 538,441 (213)

Histone Post‐Translational Modifications Regulating Ferroptosis: The Molecular Mechanisms and Disease Associations

Cell Biochemistry and Function, Volume 44, Issue 9, September 2026.
ABSTRACT Ferroptosis is a form of programmed cell death characterized by iron‐dependent phospholipid peroxidation and is implicated in a wide range of human diseases. Emerging evidence highlights the critical role of epigenetic regulation in this process.
Xiaoqian Tang, Haodang Luo, Siqi Gao, Xiaocheng Liu, Qing Sun, Yanhua Zeng   +5 more
wiley   +1 more source

Plasma exosomal miR‐339‐3p promotes myocardial remodeling in chronic heart failure by regulating USP25‐mediated DDX58 deubiquitination

Journal of Cell Communication and Signaling, Volume 20, Issue 3, September 2026.
In the patients of chronic heart failure (HF), miR‐339‐3p derived from plasma exosomes can target ubiquitin‐specific protease 25, inhibiting its K48‐linked deubiquitination modification of DDX58, leading to increased ubiquitination and degradation of DDX58.
Guoqiang Jing, Ting Xu, Yuhong Ma
wiley   +1 more source

Glut3/Tnfaip3-Mediated Pad4 Deubiquitination In Nets Formation During Periodontitis

International Dental Journal
Aim or purpose: ScRNA-seq identified GLUT3 as a pivotal molecule within the NETs-related subpopulation, while its regulatory role and mechanism in the excessive formation of NETs during periodontitis remain unclear.
Jindou Zhong, Fuchun Fang, Wei Qiu
doaj   +1 more source

FOXO6 inhibits SMURF2‐mediated ubiquitination and degradation of NR4A1 to promote retinal pigment epithelial cell ferroptosis in diabetic retinopathy

Journal of Cell Communication and Signaling, Volume 20, Issue 3, September 2026.
FOXO6 suppresses the transcriptional expression of SMURF2, thereby limiting the ubiquitination and degradation of NR4A1. Stabilized NR4A1 promotes ferroptosis in RPE cells, contributing to the progression of diabetic retinopathy. Abstract Diabetic retinopathy (DR) is the main cause of vision loss, with retinal pigment epithelial (RPE) cell dysfunction ...
Qiao Chen, Bo Su, Ke Xu, Liang Li, Changzheng Chen   +4 more
wiley   +1 more source

Deubiquitinating enzymes AtUBP12 and AtUBP13 and their tobacco homologue NtUBP12 are negative regulators of plant immunity

, 2011
Signalling by ubiquitination is implicated in diverse aspects of the plant lifecycle, and enzymes of ubiquitin metabolism are overrepresented in the Arabidopsis genome compared with other model eukaryotes.
Richard Ewan, O’Donnell, Liz, Sadanandom, Ari, Craig, Adam, Craig, A. (Adam), Adam Craig, Zhang, Cunjn, Thornber, Sarah, Pangestuti, Ratih, Ratih Pangestuti, Thornber, Sarah Elizabeth, Sarah Thornber, Cunjn Zhang, Ari Sadanandom, Liz O’Donnell, Craig Carr, Ewan, Richard, Zhang, Cunjin, Carr, Craig   +18 more
core   +1 more source

TRIM25 facilitates mitochondrial dysfunction and extracellular matrix degradation by enhancing USP7‐driven ENO1 deubiquitination during intervertebral disc degeneration

Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.
Under conditions of low TRIM25 expression, the ubiquitination fate of ENO1 shifts to K48‐linked ubiquitination and degradation. TRIM25 enhances the deubiquitination of ENO1 by recruiting USP7, effectively inhibiting its proteasomal degradation and significantly increasing ENO1 stabilization.
Xiaoming Liu, Wenyu Zhang, Hang Feng, Linying Lai, Chen Cao, Guang Yang, Yanzheng Gao, Bijun Wang, Hui Wang, Bin Yu, Zhenghong Yu   +10 more
wiley   +1 more source

PRAME promotes invasion and metastasis of salivary adenoid cystic carcinoma by regulating RARα stability via the cullin2 ubiquitin‐proteasome system

Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.
PRAME promotes SACC invasion and metastasis by inducing EMT via Twist1 upregulation and by destabilizing RARα through Cullin2‑mediated ubiquitination, a mechanism that may limit ATRA efficacy. In vivo, PRAME enhances subcutaneous growth and lung metastasis, highlighting its oncogenic role in SACC.
Xudong Wang, Tingyao Ma, Yixin Jing, Tianyi Li, Xi Zhao, Guohan Zhao, Ran Gao, Lu Kong, Xiaohong Chen   +8 more
wiley   +1 more source

Putative role of SUMOylation in controlling the activity of deubiquitinating enzymes in cancer.

, 2016
Deubiquitinating enzymes (DUBs) are specialized proteins that can recognize ubiquitinated proteins, and after direct interaction, deconjugate monomeric or polymeric ubiquitin chains, thus changing the fate of the substrates.
Massoumi, Ramin, Masoumi, Katarzyna, Massoumi, Ramin,, Masoumi, Katarzyna,, Wu, Yingli, Marfany, Gemma,, Wu, Yingli,, Lund University., Marfany, Gemma   +8 more
core   +1 more source

METTL14 Regulates Myocardial Infarction Progression via m6A‐Dependent Modulation of OTUD1‐Mediated Deubiquitination of DUSP6

The Kaohsiung Journal of Medical Sciences, Volume 42, Issue 9, September 2026.
ABSTRACT Myocardial infarction (MI) is the most severe clinical manifestation of coronary artery diseases (CVD) and serves as a critical driver of sudden cardiac death and heart failure (HF). Its pathophysiology begins with the abrupt cessation of coronary blood flow, leading to severe ischemia and subsequent cardiomyocyte necrosis. This study aimed to
Cheng‐Cheng Wei, Ya‐Fang Shen, Jin‐Yu Zhang   +2 more
wiley   +1 more source

Targeting deubiquitinating enzymes in cancer: navigating context-dependence for precision medicine

Oncologie
The ubiquitin-proteasome system (UPS) is a master regulator of protein homeostasis, and its dysregulation is a well-established driver of oncogenesis, metastasis, and therapeutic resistance.
Khamjan Nizar A.
doaj   +1 more source