Results 101 to 110 of about 538,441 (213)

Research advances in the role of ubiquitin-specific protease 25 in different malignant tumors [PDF]

精准医学杂志
Ubiquitin-specific protease 25 (USP25) is an important member of the seven major families of deubiquitinating enzymes (DUBs), and it can exert a deubiquitinating effect on substrate proteins and activate different signaling pathways, thereby regulating ...
FENG Na, ZHANG Qing, FANG Haotian, LI Qingshan, XU Fan
doaj   +1 more source

Macrophage Dab1 Links Early Hypoxia to Adaptive Angiogenesis to Drive Peripheral Nerve Repair

Advanced Science, EarlyView.
Schematic diagram illustrating the Dab1‐linked hypoxia signaling pathway that accelerates angiogenesis and consequent nerve regeneration. Following PNI, a hypoxic microenvironment develops. Hypoxia induces macrophage Dab1 phosphorylation, resulting in NHE‐1 upregulation, HIF‐1α stabilization, and VEGF‐A expression. This cascade promotes angiogenesis in
Xiongyao Zhou, Fan Zhang, Jiangbo Wang, Huiyuan Wang, Zongqiang Wang, Qianqian Wang, Chuikai Meng, Jialu Sun, Han Wang, Weiye Li, Ziyi Zhao, Le Qi, Xiaosong Gu, Shusen Cui, Rangjuan Cao   +14 more
wiley   +1 more source

Structure and Function of Viral Deubiquitinating Enzymes

Journal of Molecular Biology, 2017
Post-translational modification of cellular proteins by ubiquitin regulates numerous cellular processes, including innate and adaptive immune responses. Ubiquitin-mediated control over these processes can be reversed by cellular deubiquitinating enzymes (DUBs), which remove ubiquitin from cellular targets and depolymerize polyubiquitin chains.
Bailey-Elkin, B.A., Knaap, R.C.M., Kikkert, M., Mark, B.L.   +3 more
openaire   +3 more sources

Granzyme B PET Imaging Reveals Lgmn+ Macrophage‐Mediated Immune Evasion and Guides Immunotherapy in EGFR‐TKI‐Resistant NSCLC

Advanced Science, EarlyView.
Graphical illustration of 68Ga‐GZB PET/CT imaging reveals immune dynamics post‐EGFR‐TKI resistance in NSCLC; Lgmn+ macrophages‐derived Lgmn‐containing extracellular vesicles inhibit glycolysis, induce CD8+ T cell exhaustion, and targeting Lgmn restores immunotherapy sensitivity.
Dongliang Wang, Wenqin Luo, Qiufang Liu, Wenxuan Tang, Bin Zhu, Jiwei Chen, Qian Zhou, Shuang Tang, Xiaoping Xu, Shaoli Song   +9 more
wiley   +1 more source

N6‐Methyladenosine in Inflammatory Bowel Disease: An Emerging Regulator of Pathogenesis and a Novel Therapeutic Frontier

iMetaMed, EarlyView.
Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the intestine associated with an imbalance in intestinal homeostasis. m6A‐modifying enzymes, consisting of m6A writers, erasers and readers, plays a pivotal role in the pathogenesis and progression of IBD by affecting four intestinal barriers, including the intestinal mechanical ...
Jiaxian Guo, Yang Zhang, Xin Wang, Shan Cao, Jun Xu   +4 more
wiley   +1 more source

Epigenetic Regulation in the Pathogenesis of Renal Inflammation: Insights and Therapeutic Potentials

iNew Medicine, EarlyView.
ABSTRACT Renal inflammation is a common pathological process in various kidney diseases, often initiated by factors such as toxins, ischemia, or autoimmune reactions. This inflammatory response can result in structural damage and a rapid decline in renal function.
Yu‐Hang Dong, Xiao‐Yu Shen, Han‐Cheng Jin, Xiang‐Yu Li, Hao He, Xiao‐Ming Meng   +5 more
wiley   +1 more source

Regulation of Protein Degradation and Homeostasis by the Cytokine-Inducible Deubiquitinating Enzymes

, 2018
Ubiquitin-proteasome system (UPS) is the major signaling pathway responsible for regulating protein turnover in cells. Deubiquitinating enzymes (DUBs) have an important role in this signaling pathway by eliminating ubiquitins from substrates and ...
Baek Kwang-Hyun, Kwang-Hyun Baek
core   +1 more source

The role of the ubiquitin-proteasome system in the development of acute myocardial injury. Case report

Терапевтический архив
Background. Acute myocardial injury (AMI) is a universal pathological process that complicates both cardiac and non-cardiac pathologies. However, understanding of the molecular mechanisms underlying the various types of AMI remains insufficient.
Dmitry A. Kudlay, Vadim V. Tarasov, Elena A. Smolyarchuk, Vlas S. Shchekin, Ksenia A Zavadich, Vladislav I. Korunas, Irina D. Krylova, Aleksandr V. Samorodov   +7 more
doaj   +1 more source

Comprehensive Landscape of Active Deubiquitinating Enzymes Profiled by Advanced Chemoproteomics

Frontiers in Chemistry, 2019
Enzymes that bind and process ubiquitin, a small 76-amino-acid protein, have been recognized as pharmacological targets in oncology, immunological disorders, and neurodegeneration.
Adán Pinto-Fernández, Adán Pinto-Fernández, Simon Davis, Simon Davis, Abigail B. Schofield, Abigail B. Schofield, Hannah C. Scott, Hannah C. Scott, Ping Zhang, Ping Zhang, Eidarus Salah, Eidarus Salah, Eidarus Salah, Sebastian Mathea, Sebastian Mathea, Philip D. Charles, Philip D. Charles, Andreas Damianou, Andreas Damianou, Gareth Bond, Gareth Bond, Roman Fischer, Roman Fischer, Benedikt M. Kessler, Benedikt M. Kessler   +24 more
doaj   +1 more source

Adss1–HDAC3 Interaction: A Novel Mechanism for Epigenetic Regulation of Metabolism in Adipose Tissue

iNew Medicine, EarlyView.
ABSTRACT Obesity and its related metabolic disorders have emerged as global public health challenges with underlying mechanisms involving an imbalance between energy storage and expenditure in the adipose tissue. In recent years, with the deepening research on adipose tissue metabolism, the cross talk between metabolic enzymes and epigenetic regulation
Jiarui Zhao, Jingjing Sun, Yan Lu, Ying Yang   +3 more
wiley   +1 more source