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The C-degron pathway eliminates mislocalized proteins and products of deubiquitinating enzymes. [PDF]

open access: yesEMBO J, 2021
Yeh CW   +10 more
europepmc   +1 more source

Deubiquitinating Enzymes Regulate Skeletal Muscle Mitochondrial Quality Control and Insulin Sensitivity in Patients With Type 2 Diabetes. [PDF]

open access: yesJ Cachexia Sarcopenia Muscle
Dantas WS   +12 more
europepmc   +1 more source
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Deubiquitinating enzyme YOD1 deubiquitinates and destabilizes α-synuclein

Biochemical and Biophysical Research Communications, 2023
α-synuclein is one of the proteins involved in degenerative neuronal diseases such as Parkinson's disease (PD) or Lewy body dementia (LBD). The pathogenesis is imparted by the abnormal accumulation of α-synuclein resulting in the formation of a Lewy body (LB) and exerting neurotoxicity via an unknown mechanism.
Sang-Soo Park   +4 more
openaire   +2 more sources

Enzymes of ubiquitination and deubiquitination

Essays in Biochemistry, 2012
Ubiquitination, the covalent attachment of the small protein modifier ubiquitin to a substrate protein is involved in virtually all cellular processes by mediating the regulated degradation of proteins. Aside from proteasomal degradation, ubiquitination plays important roles in transcriptional regulation, protein trafficking, including endocytosis and ...
Neutzner, M., Neutzner, A.
openaire   +3 more sources

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