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Mechanisms, biology and inhibitors of deubiquitinating enzymes
Nature Chemical Biology, 2007The addition of ubiquitin (Ub) and ubiquitin-like (Ubl) modifiers to proteins serves to modulate function and is a key step in protein degradation, epigenetic modification and intracellular localization. Deubiquitinating enzymes and Ubl-specific proteases, the proteins responsible for the removal of Ub and Ubls, act as an additional level of control ...
Kerry Routenberg, Love +3 more
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Inhibiting the deubiquitinating enzymes (DUBs).
Journal of medicinal chemistry, 2015The diverse roles of deubiquitinating enzymes, or DUBs, in determining the fate of specific proteins continue to unfold. Concurrent with the revelation of DUBs as potential therapeutic targets are publications of small molecule inhibitors of these enzymes.
Chudi, Ndubaku, Vickie, Tsui
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The therapeutic potential of deubiquitinating enzyme inhibitors
Biochemical Society Transactions, 2010Proteases play a key role in various pathological processes and several protease inhibitors are already available for treatment. DUBs (deubiquitinating enzymes) constitute one of the largest classes of human proteases and are key effectors of the ubiquitin–proteasome system.
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Carbohydrate-active enzymes (CAZymes) in the gut microbiome
Nature Reviews Microbiology, 2022Jacob F Wardman +2 more
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Structural biology of CRISPR–Cas immunity and genome editing enzymes
Nature Reviews Microbiology, 2022Joy Y Wang +2 more
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Matching the kinetics of natural enzymes with a single-atom iron nanozyme
Nature Catalysis, 2021Yuanjun Chen, Juncai Dong, Rui Gao
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Inhibiting the Deubiquitinating Enzymes (DUBs)
Journal of Medicinal Chemistry, 2014Chudi Ndubaku, Vickie Tsui
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