Results 121 to 130 of about 27,539 (236)

The role of ubiquitination and deubiquitination in the regulation of cell junctions

Protein & Cell, 2017
Maintenance of cell junctions plays a crucial role in the regulation of cellular functions including cell proliferation, permeability, and cell death.
Junting Cai, Miranda K. Culley, Yutong Zhao, Jing Zhao   +3 more
doaj   +1 more source

Molecular basis of Lys11-polyubiquitin specificity in the deubiquitinase Cezanne [PDF]

, 2016
The post-translational modification of proteins with polyubiquitin regulates virtually all aspects of cell biology. Eight distinct chain linkage types in polyubiquitin co-exist and are independently regulated in cells.
A Borodovsky, A Bremm, A Bremm, A Luong, AJ McCoy, Bianca D. M. van Tol, C Vonrhein, D Komander, D Komander, David Komander, F Pareja, Farid El Oualid, G Bricogne, GH Pham, H Hu, H Hu, H Tran, Huib Ovaa, IE Wertz, J Jin, JC Christianson, JDF Licchesi, John E. Burke, K Enesa, K Keusekotten, KE Wickliffe, Malte Gersch, Masato Akutsu, Masato Kawasaki, MK Hospenthal, Monique P.C. Mulder, MPC Mulder, NS Berrow, P Emsley, P Evans, Paul P. Geurink, Paul R. Elliott, PD Adams, PP Geurink, PP Geurink, PR Evans, R Ekkebus, R Wiener, R Wiener, S Faggiano, S Moniz, S Vijay-Kumar, S-C Lin, Sarah L. Maslen, SG Hymowitz, Stefan M.V. Freund, TE Messick, TET Mevissen, TGG Battye, Tycho E. T. Mevissen, W Kabsch, Y-C Juang, Yogesh Kulathu   +57 more
core   +2 more sources

Translating cardiovascular ion channel and Ca2+ signalling mechanisms into therapeutic insights

The Journal of Physiology, EarlyView.
Abstract figure legend This white paper integrates mechanistic discoveries across ion channel biology, Ca2+ signalling and multiscale cardiovascular physiology to highlight new opportunities for accelerating research and guiding next‐generation therapies. Printed with permission from ®Anita Impagliazzo Medical Illustration. [Correction added on 2 March
Silvia Marchianò, Miguel Martín‐Aragón Baudel, Charlotte E. R. Smith, Gonzalo Hernandez Hernandez, Donald M. Bers, Patrick M. Boyle, Dobromir Dobrev, Shanna Hamilton, Osama F. Harraz, Na Li, Thomas A. Longden, William E. Louch, Madeline Nieves‐Cintron, Matthew A. Nystoriak, Walter Lee Murfee, Przemysław B. Radwański, Swapnil K. Sonkusare, Manuel F. Navedo, Eleonora Grandi   +18 more
wiley   +1 more source

Bisdemethoxycurcumin Inhibits Hepatocellular Carcinoma Proliferation Through Akt Inactivation via CYLD-Mediated Deubiquitination

Drug Design, Development and Therapy, 2020
Chengjiang Qiu,1 Kairui Liu,1 Sheng Zhang,1 Simin Gao,2 Weirun Chen,1 Dateng Li,3 Youxing Huang1 1Department of Abdominal Surgery, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong Province, People’s ...
Qiu C, Liu K, Zhang S, Gao S, Chen W, Li D, Huang Y   +6 more
doaj  

A plague of deubiquitination [PDF]

The Journal of Experimental Medicine, 2005
Plague bacteria inject infected host cells with a ubiquitin-chopping enzyme, according to Zhou and colleagues in a study on [page 1327][1]. The group shows that the virulence factor YopJ operates as a deubiquitinase to shut down multiple signaling pathways that would otherwise help trigger ...
openaire   +1 more source

Exercise serum promotes DNA damage repair and remodels gene expression in colon cancer cells

International Journal of Cancer, Volume 158, Issue 10, Page 2641-2649, 15 May 2026.
What's New? Exercise releases bioactive molecules into the bloodstream that can directly slow cancer cell growth. In colon cancer, this may help limit disease progression. Here, using colon cancer cells, the authors investigated the effects of exercise‐conditioned human serum on DNA repair mechanisms. Notably, acute exercise in humans elicited systemic
Samuel T. Orange, Emily Dodd, Sharanya Nath, Hannah Bowden, Alastair R. Jordan, Hannah Tweddle, Ann Hedley, Ifeoma Chukwuma, Ian Hickson, Sweta Sharma Saha   +9 more
wiley   +1 more source

Ubiquitination and deubiquitination of PCNA in response to stalling of the replication fork [PDF]

, 2009
Following exposure of human cells to DNA damaging agents that block the progress of the replication fork, mono-ubiquitination of PCNA mediates the switch from replicative DNA polymerases to polymerases specialised for translesion synthesis. We have shown
Brown, Stephanie, Lehmann, Alan R, Niimi, Atsuko   +2 more
core   +2 more sources

A new map to understand deubiquitination

Biochemical Society Transactions, 2010
Deubiquitination is a crucial mechanism in ubiquitin-mediated signalling networks. The importance of Dubs (deubiquitinating enzymes) as regulators of diverse cellular processes is becoming ever clearer as new roles are elucidated and new pathways are shown to be affected by this mechanism.
Katz, Elijah J., Isasa, Marta, Crosas, Bernat   +2 more
openaire   +3 more sources

ORMDL Proteins Turnover via Proteasome and Autophagy Is Cell‐Type Dependent and Tied to Ceramide Homeostasis

The FASEB Journal, Volume 40, Issue 6, 31 March 2026.
ORMDL proteins in the endoplasmic reticulum (ER) negatively regulate serine palmitoyltransferase (SPT) activity in response to the rate of de novo sphingolipid synthesis. Disruption of ceramide homeostasis by myriocin or fumonisin B1 (FB1) appears to destabilize the ORMDL‐SPT complex, leading to ORMDL degradation as a feedback mechanism.
Michal Mrkacek, Magda Tumova, Alex Puskasu, Pavol Utekal, Marek Vrbacky, Ladislav Kuchar, Petr Draber, Viktor Bugajev   +7 more
wiley   +1 more source

USP13 regulates ferroptosis in chicken follicle granulosa cells by deubiquitinating ATG7

Poultry Science
: The development and maturation of follicles are intricately linked to egg production and reproductive performance of chickens. Granulosa cells death directly affects the development and maturation of follicles, thereby impacting the reproductive ...
Shunshun Han, Chunlin Yu, Mohan Qiu, Xia Xiong, Han Peng, Xiaoyan Song, Chenming Hu, Zengrong Zhang, Bo Xia, Li Yang, Jialei Chen, Shiliang Zhu, Wen Li, Chaowu Yang   +13 more
doaj   +1 more source