Bacterial Interference of Ubiquitination and Deubiquitination [PDF]
Cell Host & Microbe, 2007 Ubiquitination and deubiquitination regulate several essential cellular processes such as protein degradation, cell-cycle progression, signaling, and DNA repair. Given the importance of these processes, it is not surprising that many microbes have developed the means to interfere with different stages of ubiquitin pathways to promote their survival and
Rytkönen, Anne, Holden, David W.
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Frontiers in Oncology, 2022 Regulation of ubiquitination is associated with multiple processes of tumorigenesis and development, including regulation of the tumor immune microenvironment.
Jinhui Guo +4 more
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Ubp8 and SAGA Regulate Snf1 AMP kinase Activity [PDF]
, 2011 Posttranslational modifications of histone proteins play important roles in the modulation of gene expression. The Saccharomyces cerevisiae (yeast) 2-MDa SAGA (Spt-Ada-Gcn5) complex, a well-studied multisubunit histone modifier, regulates gene expression
Wilson, Marenda A. +6 more
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Deubiquitinating enzyme USP10 promotes hepatocellular carcinoma metastasis through deubiquitinating and stabilizing Smad4 protein [PDF]
Molecular Oncology, 2019 Hepatocellular carcinoma (HCC) has emerged as one of the most prevalent life‐threatening cancers, and the high mortality rate is largely due to the metastasis. The sustained activation of Smad4 and transforming growth factor‐β (TGF‐β) is closely associated with advanced HCC metastasis.
Tao Yuan +12 more
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Cellular functions and molecular mechanisms of ubiquitination in osteosarcoma
Frontiers in Oncology, 2022 Although some advances have been made in the treatment of osteosarcoma in recent years, surgical resection remains the mainstream treatment. Initial and early diagnosis of osteosarcoma could be very difficult to achieve due to the insufficient ...
Jiaxun Song +8 more
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EGF receptor trafficking: consequences for signaling and cancer [PDF]
, 2013 The ligand-stimulated epidermal growth factor receptor (EGFR) has been extensively studied in the analysis of molecular mechanisms regulating endocytic traffic and the role of that traffic in signal transduction.
Eden, ER, Futter, CE, Tomas, A
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USP14 regulates cell cycle progression through deubiquitinating CDK1 in breast cancer
Acta Biochimica et Biophysica Sinica, 2022 Abnormal proliferation and cell cycle perturbation are the main hallmarks of breast cancer. Cyclin-dependent kinase 1 (CDK1) is one of the key kinases for cell transition from the G2 phase to M phase during the cell cycle progression.
Liu Yuhan +6 more
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Molecular characterization and analysis of the acrB gene of Aspergillus nidulans: A gene identified by genetic interaction as a component of the regulatory network that includes the CreB deubiquitination enzyme [PDF]
, 2003 Copyright © 2003 by the Genetics Society of AmericaMutations in the acrB gene, which were originally selected through their resistance to acriflavine, also result in reduced growth on a range of sole carbon sources, including fructose, cellobiose ...
Adams, J. +4 more
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RETREG1‐Mediated Reticulophagy is Essential for Dendritic Cell Maturation and Function in Sepsis
Advanced Science, EarlyView.Reticulophagy regulator 1 (RETREG1) maintains dendritic cell (DC) maturation and function in early sepsis. Mechanistically, activating transcription factor 6 (ATF6) acts as a direct transcription factor regulating RETREG1 expression in response to sepsis‐induced endoplasmic reticulum (ER) stress.
Ren‐Qi Yao +28 more
wiley +1 more source
The centrosomal deubiquitylase USP21 regulates Gli1 transcriptional activity and stability [PDF]
, 2016 USP21 is a centrosome-associated deubiquitylase (DUB) that has been implicated in the formation of primary cilia - crucial organelles for the regulation of the Hedgehog (Hh) signaling pathway in vertebrates. Here, we identify KCTD6 - a cullin-3 E3-ligase
Bertsoulaki, Erithelgi +6 more
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