Results 71 to 80 of about 27,539 (236)

SCFβ-TRCP regulates osteoclastogenesis via promoting CYLD ubiquitination [PDF]

, 2014
CYLD negatively regulates the NF-κB signaling pathway and osteoclast differentiation largely through antagonizing TNF receptor-associated factor (TRAF)-mediated K63-linkage polyubiquitination in osteoclast precursor cells.
Deng, Feng, Fukushima, Hidefumi, Inuzuka, Hiroyuki, Nagaoka, Yoshiyuki, Nagashima, Katsuyuki, North, Brian J., Okabe, Koji, Wei, Wenyi, Wu, Xiaomian   +8 more
core   +1 more source

Endocytosis: Why not wait to deubiquitinate? [PDF]

Current Biology, 2000
Deubiquitination by the Fat facets protein - a regulator of photoreceptor differentiation during Drosophila eye development - has been found to activate endocytosis, while ubiquitination inhibits endocytosis. Surprisingly, this is the opposite effect that ubiquitination has on endocytosis of many plasma membrane proteins.
Carthew, Richard W., Xu, Chunyan
openaire   +2 more sources

Chaperone‐Mediated Autophagic Degradation of USP9X in Macrophages Exacerbates Postmyocardial Infarction Inflammation and Cardiac Dysfunction

Advanced Science, EarlyView.
This study demonstrates that inflammatory stimuli induce the acetylation‐triggered, chaperone‐mediated autophagic degradation of ubiquitin‐specific peptidase 9 X‐linked (USP9X) in macrophages. USP9X acts as a macrophage “inflammation switch” after myocardial infarction (MI). USP9X loss destabilizes tumor necrosis factor receptor‐associated factor (TRAF)
Biqing Wang, Xiangheng Cai, Mengqi Li, Xue Liu, Junhui Xue, Ye Liu, Ding Ai, Xinyang Hu   +7 more
wiley   +1 more source

Ectopic USP15 expression inhibits HIV-1 transcription involving changes in YY1 deubiquitination and stability

Frontiers in Cellular and Infection Microbiology
IntroductionProtein homeostasis is maintained by the opposing action of ubiquitin ligase and deubiquitinase, two important components of the ubiquitin-proteasome pathway, and contributes to both normal physiological and pathophysiological processes.
Sahar Rezaei, Sahar Rezaei, Sahar Rezaei, Khalid A. Timani, Khalid A. Timani, Khalid A. Timani, Ying Liu, Ying Liu, Ying Liu, Johnny J. He, Johnny J. He, Johnny J. He   +11 more
doaj   +1 more source

Deubiquitinase DUB3 Regulates Cell Cycle Progression via Stabilizing Cyclin A for Proliferation of Non-Small Cell Lung Cancer Cells

Cells, 2019
The deubiquitinase DUB3 is frequently overexpressed in non-small cell lung cancer (NSCLC) and contributes to its malignant phenotype. However, the underlying molecular mechanism of DUB3 in NSCLC is largely unknown.
Bin Hu, Tanggang Deng, Hongchang Ma, Yan Liu, Peifu Feng, Dong Wei, Neng Ling, Ling Li, Siyuan Qiu, Lin Zhang, Bo Peng, Jing Liu, Mao Ye   +12 more
doaj   +1 more source

Proteasome Inhibitors: Harnessing Proteostasis to Combat Disease [PDF]

, 2020
The proteasome is the central component of the main cellular protein degradation pathway. During the past four decades, the critical function of the proteasome in numerous physiological processes has been revealed, and proteasome activity has been linked
Li, Jing, Sherman, David J.
core  

Regulation of endoplasmic reticulum-associated protein degradation (ERAD) by ubiquitin [PDF]

, 2014
Quality control of protein folding inside the endoplasmic reticulum (ER) includes chaperone-mediated assistance in folding and the selective targeting of terminally misfolded species to a pathway called ER-associated protein degradation, or simply ERAD.
Goder, Veit, Lemus Rodríguez,Leticia
core   +2 more sources

USP21 modulates Goosecoid function through deubiquitination [PDF]

Bioscience Reports, 2019
AbstractThe homeobox gene Goosecoid (GSC), which is known to regulate craniofacial development, is activated by mono-ubiquitination; however, the deubiquitylase responsible for GSC deubiquitination and inhibition has yet to be identified. In the present study, we constructed the recombinant plasmid pFlag-CMV-2-GSC and the SRY (sex-determining region Y)-
Fuwei Liu, Qian Fu, Yunpeng Li, Kai Zhang, Mingyue Tang, Wei Jiang, Bin Bo, Yajun Cui, Liang Kong   +8 more
openaire   +2 more sources

Targeted Mitochondrial ECSIT Overexpression Attenuates MASH by Increasing OTUD3 Expression

Advanced Science, EarlyView.
Mitochondrial ECSIT expression is reduced during MASH pathogenesis. Overexpression of mitochondrial ECSIT mitigates steatohepatitis and maintains hepatic metabolic homeostasis. Mechanistically, ECSIT enhances intramitochondrial OTUD3 expression to stabilize SIRT3 through deubiquitination, thus preserving mitochondrial function and impeding disease ...
Yuqing Jiang, Tingting Tong, Pengxi Shi, Xiaofan Chen, Chenhao Wang, Qingyuan Weng, Sihan Chen, Linli Que, Qi Chen, Yuehua Li, Qiang Zhu, Jiantao Li   +11 more
wiley   +1 more source

Ubiquitin-specific protease 29 attenuates hepatic ischemia-reperfusion injury by mediating TGF-β-activated kinase 1 deubiquitination

Frontiers in Immunology, 2023
Background and aimsIn the course of clinical practice, hepatic ischemia/reperfusion (I/R) injury is a prevalent pathophysiological event and is caused by a combination of complex factors that involve multiple signaling pathways such as MAPK and NF-κB ...
Zhongbao Chen, Zhongbao Chen, Fengjiao Hu, Yalong Zhang, Yalong Zhang, Long Zhang, Long Zhang, Tianyu Wang, Tianyu Wang, Chenyang Kong, Chenyang Kong, Haochong Hu, Haochong Hu, Jiayu Guo, Jiayu Guo, Qi Chen, Qi Chen, Bo Yu, Bo Yu, Yiting Liu, Yiting Liu, Jilin Zou, Jilin Zou, Jiangqiao Zhou, Jiangqiao Zhou, Tao Qiu, Tao Qiu   +26 more
doaj   +1 more source