Results 81 to 90 of about 27,539 (236)

The proteasome lid triggers COP9 signalosome activity during the transition of Saccharomyces cerevisiae cells into quiescence. [PDF]

, 2019
The class of Cullin–RING E3 ligases (CRLs) selectively ubiquitinate a large portion of proteins targeted for proteolysis by the 26S proteasome. Before degradation, ubiquitin molecules are removed from their conjugated proteins by deubiquitinating enzymes,
Bramasole, Lylan, Cirigliano, Angela, Glickman, Michael H., Gurevich, Sylvia, Harshuk, Dana, Pick, Elah, Rinaldi, Teresa, Sinha, Abhishek, Yu, Zanlin   +8 more
core  

Revealing a novel Otubain-Like Enzyme from Leishmania infantum with deubiquitinating activity toward K48-linked substrate [PDF]

, 2017
Deubiquitinating enzymes (DUBs) play an important role in regulating a variety of eukaryotic processes. In this context, exploring the role of deubiquitination in Leishmania infantum could be a promising alternative to search new therapeutic targets for ...
Azevedo, Clênia dos Santos, Bastos, Izabela Marques Dourado, Corrêa, Rafael, Grellier, Philippe, Guido, Bruna Cândido, Magalhães, Kelly Grace, Motta, Flávia Nader, Nolasco, Diego O., Pereira, Jhonata L., Santana, Jaime Martins de   +9 more
core   +1 more source

Pro‐ATO/Allicin Liposomes for Dual‐Pathway Targeting of p53‐Mutant Tumors

Advanced Science, EarlyView.
Schematic illustration of the “pro‐ATO”/allicin liposomal strategy. Liposomal encapsulation improves the stability and bioavailability of both agents while masking allicin's odor. Upon release in the tumor microenvironment, ATO reactivates structural p53 mutants, and allicin inhibits ATR signaling while releasing H2S, collectively inducing synthetic ...
Xiaoling Xu, WeiYi Cheng, Menghang Yang, Li He, WeiYe Ren, JingQuan Chen, LiTing He, Dandan Bao, Zhihong Zhu, Lixin Wang, Qinghua Yao, Ji‐Gang Piao   +11 more
wiley   +1 more source

USP13 antagonizes gp78 to maintain functionality of a chaperone in ER-associated degradation [PDF]

, 2014
Physiological adaptation to proteotoxic stress in the endoplasmic reticulum (ER) requires retrotranslocation of misfolded proteins into the cytoplasm for ubiquitination and elimination by ER-associated degradation (ERAD).
Clemons, William M., Jr., Lee, Jin-gu, Liu, Liping, Liu, Yanfen, Soetandyo, Nia, Xu, Yue, Ye, Yihong   +6 more
core   +1 more source

Glutamine Deprivation Triggers Tribbles Homolog 3 Dependent G‐Quadruplex Resolution to Maintain DNA Repair and Tumor Survival

Advanced Science, EarlyView.
Glutamine deprivation triggers transient DNA damage yet activates adaptive repair in hepatocellular carcinoma cells. We identify TRIB3 as a stress‐induced nuclear scaffold that associates with DDX5 and G‐quadruplex DNA atBRCA1 andRAD51AP1 promoters. TRIB3 loss increases G4 accumulation, suppresses HR gene transcription, elevates γ‐H2A.X, and sensitizes
Qiang Ji, Xuedan Sun, Zhangran Sun, Mengfan Li, Xinyu Cheng, Shuai Tian, Rick F. Thorne, Jinming Li, Guangzhi Liu, Mian Wu, Xiaoying Liu   +10 more
wiley   +1 more source

Roles of ubiquitin-specific proteases in inflammatory diseases

Frontiers in Immunology
Ubiquitin-specific proteases (USPs), as one of the deubiquitinating enzymes (DUBs) families, regulate the fate of proteins and signaling pathway transduction by removing ubiquitin chains from the target proteins.
Rui Chen, Rui Chen, Rui Chen, Hui Zhang, Hui Zhang, Linke Li, Linke Li, Jinsheng Li, Jiang Xie, Jie Weng, Huan Tan, Huan Tan, Yanjun Liu, Yanjun Liu, Tailin Guo, Tailin Guo, Mengyuan Wang, Mengyuan Wang, Mengyuan Wang   +18 more
doaj   +1 more source

The Deubiquitinating Enzyme Inhibitor PR-619 Enhances the Cytotoxicity of Cisplatin via the Suppression of Anti-Apoptotic Bcl-2 Protein: In Vitro and In Vivo Study

Cells, 2019
After chemotherapy for the treatment of metastatic bladder urothelial carcinoma (UC), most patients inevitably encounter drug resistance and resultant treatment failure.
Kuan-Lin Kuo, Shing-Hwa Liu, Wei-Chou Lin, Po-Ming Chow, Yu-Wei Chang, Shao-Ping Yang, Chung-Sheng Shi, Chen-Hsun Hsu, Shih-Ming Liao, Hong-Chiang Chang, Kuo-How Huang   +10 more
doaj   +1 more source

Riding the DUBway: regulation of protein trafficking by deubiquitylating enzymes [PDF]

, 2006
Ubiquitylation is a key regulator of protein trafficking, and much about the functions of ubiquitin ligases, which add ubiquitin to substrates in this regulation, has recently come to light.
Millard, Stephen A., Wood, Susan M.
core   +2 more sources

m5C‐Modified tRF3b‐CysGCA‐23 Suppresses Bladder Cancer Malignancy by Repressing H3K18 Lactylation via Stabilizing RBM4

Advanced Science, EarlyView.
In this study, we identified an NSUN6‐dependent m5C‐modified tsRNA, m5C‐tRF3b CysGCA‐23 (mtRC), that is downregulated in BC and inversely correlated with disease progression. Mechanistically, mtRC suppresses BC malignancy by stabilizing RBM4, attenuating glycolysis, and thereby limiting H3K18 lactylation–mediated activation of IL1RAP and VASH2 ...
Xiaoling Ying, Yapeng Huang, Jian Huang, Qinyu Cai, Danni Zhang, Cong Chen, Yuxi Nie, Baotong Yang, Chuan Li, Wenyu Hu, Chang Xiong, Chengcheng Zhang, Ding Ji, Yaomin Liang, Mei Yang, Wenqi Wu, Weidong Ji   +16 more
wiley   +1 more source

A Novel Type of Deubiquitinating Enzyme [PDF]

Journal of Biological Chemistry, 2003
A previous report from this laboratory described two novel proteins that have sequence similarity to A20, a negative regulator of NF-kappaB (Evans, P. C., Taylor, E. R., Coadwell, J., Heyninck, K., Beyaert, R., and Kilshaw, P. J. (2001) Biochem. J. 357, 617-623).
Paul C, Evans, Trevor S, Smith, Meng-Jiun, Lai, Mark G, Williams, David F, Burke, Karen, Heyninck, Marja M, Kreike, Rudi, Beyaert, Tom L, Blundell, Peter J, Kilshaw   +9 more
openaire   +2 more sources