Results 21 to 30 of about 145,903 (280)

An Interactive Developmental Neuroscience Perspective on Adolescent Resilience to Familial Depression. [PDF]

JAMA Psychiatry, 2018
Bessette KL, Burkhouse KL, Langenecker SA.   +2 more
europepmc   +3 more sources

A developmental neuroscience perspective on affect-biased attention. [PDF]

Dev Cogn Neurosci, 2016
Morales S, Fu X, Pérez-Edgar KE.
europepmc   +2 more sources

Raging Hormones: Why Age-Based Etiological Conceptualizations of the Development of Antisocial Behavior Are Insufficient

Frontiers in Behavioral Neuroscience, 2022
Developmental science, particularly developmental neuroscience, has substantially influenced the modern legal system. However, this science has typically failed to consider the role of puberty and pubertal hormones on development when considering ...
Stuart F. White, S. Mariely Estrada Gonzalez, Eibhlis M. Moriarty   +2 more
doaj   +1 more source

Casein kinase 1α is required to maintain murine hypothalamic pro-opiomelanocortin expression

iScience, 2023
Summary: Hypothalamic pro-opiomelanocortin (POMC) neuron development is considered to play an essential role in the development of obesity. However, the underlying mechanisms remain unclear.
Chenyang Lu, Jinglin Zhang, Bingjie Wang, Qiao Gao, Kezhe Ma, Shaona Pei, Juxue Li, Sheng Cui   +7 more
doaj   +1 more source

Impaired synaptic plasticity in an animal model of autism exhibiting early hippocampal GABAergic-BDNF/TrkB signaling alterations

iScience, 2023
Summary: In Neurodevelopmental Disorders, alterations of synaptic plasticity may trigger structural changes in neuronal circuits involved in cognitive functions.
Martina Sgritta, Beatrice Vignoli, Domenico Pimpinella, Marilena Griguoli, Spartaco Santi, Andrzej Bialowas, Grzegorz Wiera, Paola Zacchi, Francesca Malerba, Cristina Marchetti, Marco Canossa, Enrico Cherubini   +11 more
doaj   +1 more source

FEZ1 participates in human embryonic brain development by modulating neuronal progenitor subpopulation specification and migrations

iScience, 2023
Summary: Mutations in the human fasciculation and elongation protein zeta 1 (FEZ1) gene are found in schizophrenia and Jacobsen syndrome patients. Here, using human cerebral organoids (hCOs), we show that FEZ1 expression is turned on early during brain ...
Yinghua Qu, Jonathan Jun-Yong Lim, Omer An, Henry Yang, Yi-Chin Toh, John Jia En Chua   +5 more
doaj   +1 more source

Neonatal exposures to sevoflurane in rhesus monkeys alter synaptic ultrastructure in later life

iScience, 2022
Summary: Repeated or prolonged early life exposure to anesthesia is neurotoxic in animals and associated with neurocognitive impairment in later life in humans.
Tristan Fehr, William G.M. Janssen, Janis Park, Mark G. Baxter   +3 more
doaj   +1 more source

Unbiased characterization of the larval zebrafish enteric nervous system at a single cell transcriptomic level

iScience, 2023
Summary: The enteric nervous system (ENS) regulates many gastrointestinal functions including peristalsis, immune regulation and uptake of nutrients.
Laura E. Kuil, Naomi J.M. Kakiailatu, Jonathan D. Windster, Eric Bindels, Joke T.M. Zink, Gaby van der Zee, Robert M.W. Hofstra, Iain T. Shepherd, Veerle Melotte, Maria M. Alves   +9 more
doaj   +1 more source

Celsr3 is required for Purkinje cell maturation and regulates cerebellar postsynaptic plasticity

iScience, 2021
Summary: Atypical cadherin Celsr3 is critical for brain embryonic development, and its role in the postnatal cerebellum remains unknown. Using Celsr3-GFP mice, Celsr3 shows high expression in postnatal Purkinje cells (PCs). Mice with conditional knockout
Qinji Zhou, Jingwen Qin, Yaying Liang, Wei Zhang, Siyuan He, Fadel Tissir, Yibo Qu, Libing Zhou   +7 more
doaj   +1 more source

Histone Deacetylase 3 Governs Perinatal Cerebral Development via Neural Stem and Progenitor Cells

iScience, 2019
Summary: We report that cerebrum-specific inactivation of the histone deacetylase 3 (HDAC3) gene causes striking developmental defects in the neocortex, hippocampus, and corpus callosum; post-weaning lethality; and abnormal behaviors, including ...
Lin Li, Jianliang Jin, Xiang-Jiao Yang
doaj   +1 more source