Results 71 to 80 of about 145,903 (280)

Decreased Serum 5‐HT: Clinical Correlates and Regulatory Role in NMJ of MG

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Although 5‐Hydroxytryptamine (5‐HT) indirectly stimulates muscle contraction and participates in regulating Acetylcholine receptor (AChR) cluster homeostasis in cellular, animal, and clinical studies, evidence regarding its potential to modulate muscle contraction in myasthenia gravis (MG) remains limited.
Xinru Shen, Jing Zhang, Xinyue Zhou, Xiaoxiao Yu, Haodong Shang, Shufan Chen, Lulu Zhen, Jinru Wu, Guanlian Hu, Xiaoyan Zhu, Zhan Sun, Yiren Wang, Jiahui Wang, Jie Lv, Xue Zhao, Yingna Zhang, Wei Guo, Ying Peng, Feng Gao   +18 more
wiley   +1 more source

Microbiota-dependent early-life programming of gastrointestinal motility

iScience
Summary: Gastrointestinal microbes modulate peristalsis and stimulate the enteric nervous system (ENS), whose development, as in the central nervous system (CNS), continues into the murine postweaning period.
Mary E. Frith, Purna C. Kashyap, David R. Linden, Betty Theriault, Eugene B. Chang   +4 more
doaj   +1 more source

Clinical Characteristics and Outcomes of Early‐Onset Versus Late‐Onset LGI1‐Antibody Encephalitis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Leucine‐rich glioma‐inactivated 1 antibody (LGI1‐Ab) encephalitis predominantly affected older individuals, but has also been reported in younger patients. However, the demographic, clinical, and prognostic characteristics of early‐onset LGI1‐Ab encephalitis have yet to be systematically elucidated. This study aims to systematically
Yu Kong, Shasha Yu, Jing Zhang, Yu Zu, Yujing Zhang, Jing Lv, Xuyang Cao, Xuedan Feng   +7 more
wiley   +1 more source

Sustained generation of neurons destined for neocortex with oxidative metabolic upregulation upon filamin abrogation

iScience
Summary: Neurons in the neocortex are generated during embryonic development. While the adult ventricular-subventricular zone (V-SVZ) contains cells with neural stem/progenitors’ characteristics, it remains unclear whether it has the capacity of ...
Caroline A. Kopsidas, Clara C. Lowe, Dennis P. McDaniel, Xiaoming Zhou, Yuanyi Feng   +4 more
doaj   +1 more source

Developmental Neuroscience: How Twitches Make Sense [PDF]

Current Biology, 2014
Animals refine the mechanics of their own bodies through sensorimotor feedback produced by physical interactions with the environment. A new study sheds light on how developing mammals may use sensations produced by spontaneous movements made during sleep to construct their sensorimotor maps.
Narayanan, Darshana Z., Ghazanfar, Asif A.   +1 more
openaire   +2 more sources

Amyotrophic Lateral Sclerosis Prevalence Projection in 2040: A Less Rare Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To project ALS prevalence across multiple countries through 2040, accounting for both population aging and increased survival. Methods Data from the Piemonte and Valle d'Aosta ALS register (PARALS) was used to estimate the trends in incidence and prevalence from 2005 to 2019. Survival trends over this period were also assessed.
Rosario Vasta, Stefano Callegaro, Antonio Canosa, Umberto Manera, Maurizio Grassano, Francesca Palumbo, Sara Cabras, Enrico Matteoni, Francesca Di Pede, Filippo De Mattei, Salvatore Tafaro, Neil M. Thakur, Ryan Grosenick, Fabiola De Marchi, Letizia Mazzini, Cristina Moglia, Andrea Calvo, Kuldip D. Dave, Adriano Chiò   +18 more
wiley   +1 more source

Developmental cognitive neuroscience

Higher Brain Function Research, 2004
発達認知神経科学とは，脳の成長と心的プロセスの発達の関係を探る学問である。神経心理学の場合，発達という変化に注目して認知機能の異常を調べるという側面からこの分野にかかわっているが，モジュールの生得性を前提としている。Williams症候群は第7染色体11.23領域の半接合体欠失による隣接遺伝子症候群であり，神経心理学的には言語が良好で視空間認知は不良という解離のみられるのが特徴で，特定の遺伝子がこの認知パターン形成にかかわると考えられ研究されている。しかし近年の研究からは，単純な「解離」ではなく，また単一の遺伝子が特定の認知機能と直接には結びつかないことも示されている。モジュールの考え方には生得主義以外にも構成主義や神経構成主義があり，その立場によって得られたデータの解釈も異なってくる ...
openaire   +2 more sources

Developmental Neuroscience Perspectives on Emotion Regulation [PDF]

Child Development Perspectives, 2008
ABSTRACT— Because individual differences in emotion regulation are associated with risk for childhood behavioral problems, multidisciplinary investigation of the genetic and neural underpinnings of emotion regulation should be a research priority.
H Hill, Goldsmith, Seth D, Pollak, Richard J, Davidson   +2 more
openaire   +2 more sources

Plasma Proteomic Signatures for Alzheimer's Disease: Comparable Accuracy to ATN Biomarkers and Cross‐Platform Validation

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background There is growing recognition of the potential of plasma proteomics for Alzheimer's Disease (AD) risk assessment and disease characterization. However, differences between proteomics platforms introduce uncertainties regarding cross‐platform applicability.
Manyue Hu, Oliver Robinson, Christina M. Lill, Anna Matton, Raquel Puerta, Pilar Sanz, Merce Boada, Agustín Ruiz, Lefkos Middleton, for the Alzheimer's Disease Neuroimaging Initiative   +9 more
wiley   +1 more source

Impact of Stress‐Induced Hyperglycemia on In‐Hospital Medical Complications in Patients With Acute Stroke: From a Large‐Scale Nationwide Longitudinal Registry

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Aims This study aimed to explore the relationship between stress‐induced hyperglycemia (SIH) and in‐hospital medical complications in patients with acute stroke. Methods We enrolled 865,765 patients with acute stroke from the Chinese Stroke Center Alliance cohort.
Xintong Song, Yi Ju, Hongqiu Gu, Zhikai Zhu, Zixiao Li, Qian Zhang, Xingquan Zhao   +6 more
wiley   +1 more source