Results 71 to 80 of about 1,316,154 (307)

Ataxin-2 is essential for cytoskeletal dynamics and neurodevelopment in Drosophila

iScience, 2022
Summary: Ataxin-2 (Atx2) is a highly conserved RNA binding protein. Atx2 undergoes polyglutamine expansion leading to amyotrophic lateral sclerosis (ALS) or spinocerebellar ataxia type 2 (SCA2).
Urko del Castillo, Rosalind Norkett, Wen Lu, Anna Serpinskaya, Vladimir I. Gelfand   +4 more
doaj   +1 more source

Children's basic memory processes, stress and maltreatment [PDF]

, 2006
Building upon methods and research utilized with normative populations, we examine extant assumptions regarding the effects of child maltreatment on memory.
Cicchetti, Dante, Howe, Mark L., Toth, Sheree L.   +2 more
core   +1 more source

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

An evolutionarily conserved role for CTNNB1/β-CATENIN in regulating the development of the corpus callosum

iScience
Summary: The corpus callosum (CC) is a major nerve bundle that connects the two hemispheres of the brain. Dysgenesis of the CC is associated with neurodevelopmental disorders such as the CTNNB1 syndrome.
Arpan Parichha, Debarpita Datta, Amrita Singh, Ishita Talwar, Shreya Yadav, Mahima Bose, Varun Suresh, Špela Miroševič, Nina Žakelj, David Gosar, Damjan Osredkar, Shubha Tole   +11 more
doaj   +1 more source

Specialization of neural mechanisms underlying face recognition in human infants [PDF]

, 2002
Newborn infants respond preferentially to simple face-like patterns, raising the possibility that the face-specific region, identified in the adult cortex are functioning from birth. We sought to evaluate this hypothesis by characterizing the specificity
de Haan, M, Johnson, MH, Pascalis, O
core   +2 more sources

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

The amplitude of fNIRS hemodynamic response in the visual cortex unmasks autistic traits in typically developing children

Translational Psychiatry, 2022
Autistic traits represent a continuum dimension across the population, with autism spectrum disorder (ASD) being the extreme end of the distribution. Accumulating evidence shows that neuroanatomical and neurofunctional profiles described in relatives of ...
Raffaele Mazziotti, Elena Scaffei, Eugenia Conti, Viviana Marchi, Riccardo Rizzi, Giovanni Cioni, Roberta Battini, Laura Baroncelli   +7 more
doaj   +1 more source

Theories of the development of human communication [PDF]

, 2013
This article considers evidence for innate motives for sharing rituals and symbols from animal semiotics, developmental neurobiology, physiology of prospective motor control, affective neuroscience and infant communication. Mastery of speech and language
Delafield-Butt, Jonathan, Trevarthen, Colwyn   +1 more
core  

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

SRSF10 regulates proliferation of neural progenitor cells and affects neurogenesis in developing mouse neocortex

iScience, 2023
Summary: Alternative pre-mRNA splicing plays critical roles in brain development. SRSF10 is a splicing factor highly expressed in central nervous system and plays important roles in maintaining normal brain functions.
Junjie Li, Hanyang Jiang, Yawei Mu, Zixuan Wei, Ankangzhi Ma, Menghan Sun, Jingjing Zhao, Cuiqing Zhu, Xianhua Chen   +8 more
doaj   +1 more source