Organoid intelligence for developmental neurotoxicity testing [PDF]
Frontiers in Cellular NeuroscienceThe increasing prevalence of neurodevelopmental disorders has highlighted the need for improved testing methods to determine developmental neurotoxicity (DNT) hazard for thousands of chemicals. This paper proposes the integration of organoid intelligence
Dowlette-Mary Alam El Din +9 more
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Developmental Neurotoxicity of Difenoconazole in Zebrafish Embryos [PDF]
Toxics, 2023 Difenoconazole is a type of triazole fungicide that is widely used in the treatment of plant diseases. Triazole fungicides have been shown in several studies to impair the development of the nervous system in zebrafish embryos.
Qing Yang +12 more
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Stem cell-based approaches for developmental neurotoxicity testing [PDF]
Frontiers in ToxicologyNeurotoxicants are substances that can lead to adverse structural or functional effects on the nervous system. These can be chemical, biological, or physical agents that can cross the blood brain barrier to damage neurons or interfere with complex ...
Joy Ku, Prashanth Asuri
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Developmental fluoride neurotoxicity: an updated review [PDF]
Environmental Health, 2019 Background After the discovery of fluoride as a caries-preventing agent in the mid-twentieth century, fluoridation of community water has become a widespread intervention, sometimes hailed as a mainstay of modern public health.
Philippe Grandjean
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Methylmercury exposure and developmental neurotoxicity
Bulletin of the World Health Organization, 2014 We are concerned that certain aspects of the systematic review on methylmercury (MeHg) exposure from seafood consumption and the risk of developmental neurotoxicity published in the Bulletin of World Health Organization could be misinterpreted.1 Specifically, the review does not address the issue of whether naturally-occurring, background levels of ...
Gary J Myers +7 more
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The Role of Autophagy in Copper-Induced Apoptosis and Developmental Neurotoxicity in SH-SY5Y Cells [PDF]
ToxicsCopper (Cu) is a global environmental pollutant that poses a serious threat to humans and ecosystems. Copper induces developmental neurotoxicity, but the underlying molecular mechanisms are unknown.
Lu Lu +6 more
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Controversies in anesthesia-induced developmental neurotoxicity. [PDF]
Best Pract Res Clin Anaesthesiol, 2023 Advances in the field of pediatric anesthesiology have enabled the performance of complex and life-saving procedures with minimal patient discomfort. However, preclinical studies over the past two decades have been reporting substantial neurotoxic potential of general anesthetics in young brain, thus challenging the safety of these agents in pediatric ...
Useinovic N, Jevtovic-Todorovic V.
europepmc +3 more sources
Titanium Dioxide Nanoparticles Aggravated the Developmental Neurotoxicity of Ammonia Nitrogen on Zebrafish Embryos [PDF]
ToxicsTotal ammonia nitrogen (TAN) is a common and potent neurotoxic pollutant in aquatic environments. Due to their strong adsorption capacity, titanium dioxide nanoparticles (n-TiO2), a widely used engineered material, can induce combined toxicity with ...
Minglei Lyu +11 more
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Developmental neurotoxicity of PFOA exposure on hiPSC-derived cortical neurons [PDF]
Environment InternationalPFOA is a legacy Per- and Polyfluorinated Substances (PFAS), a group of chemicals widely used in various industrial applications and consumer products.
Shichen Wu +7 more
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A developmental neurotoxicity adverse outcome pathway (DNT‐AOP) with voltage gate sodium channel (VGSC) inhibition as a molecular initiating event (MiE) [PDF]
EFSA JournalThe adverse outcome pathway (AOP) framework serves as a practical tool for organising scientific knowledge that can be used to infer cause–effect relationships between stressor events and toxicity outcomes in intact organisms.
European Food Safety Authority (EFSA) +7 more
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