Results 101 to 110 of about 22,140 (237)

Asymmetry in Hydrophobicity Induces Electric Potential in Non‐Charged Biomolecular Condensates

Advanced Science, EarlyView.
 Non‐charged biomolecular condensates can encode electric potential gradient through defining asymmetry in environmental hydrophobicity. ABSTRACT The capacity of biomolecular condensates to establish and modulate electrochemical equilibria is emerging as an important functioning mechanism in cellular biochemistry.
Leshan Yang, Wen Yu, Xiangze Zeng, Yifan Dai   +3 more
wiley   +1 more source

Neonicotinoid Pesticides Affect Developing Neurons in Experimental Mouse Models and in Human Induced Pluripotent Stem Cell (iPSC)-Derived Neural Cultures and Organoids

Cells
Neonicotinoids are synthetic, nicotine-derived insecticides used worldwide to protect crops and domestic animals from pest insects. The reported evidence shows that they are also able to interact with mammalian nicotine receptors (nAChRs), triggering ...
Alessandro Mariani, Davide Comolli, Roberto Fanelli, Gianluigi Forloni, Massimiliano De Paola   +4 more
doaj   +1 more source

Effect Differences of Omega‐3 Fatty Acids From Plant Oil and Fish Oil on Human Health

AgriFood: Journal of Agricultural Products for Food, EarlyView.
Omega‐3 fatty acids in plant oil is no less than fish oil on human health. ALA in plant oil takes directly healthy effects without conversion to DHA and EPA. Plant oil can be substitutes for fish oil to support partial ω‐3 fatty acids. For people who cannot afford fish oil, plant oil is also good for public health.
Mengxue Fang, Chunyan Xiang, Liangxiao Zhang, Peiwu Li   +3 more
wiley   +1 more source

Hainan Longevity Model, Senile Degeneration, Cognitive Disability and Healthy Longevity

AGING MEDICINE, EarlyView.
Investigating centenarians who exemplify healthy longevity can aid in formulating preventive strategies aimed at achieving health and extending lifespan in the context of population aging. Hainan longevity model (HLM) plays key roles in promoting healthy longevity and provides scientific evidence for achieving healthy longevity in the older population.
Shihui Fu, Jiacai Lin, Qianshuo Liu, Lianbo Gao, Zhirui Li, Feng Lin, Leixing Xie, Xiong Liu, Wenkai Xiao, Qiwei Zhu, Fan Wang, Jin Zheng, Yali Zhao, Xiaolei Chen, Yao Yao, Long Feng   +15 more
wiley   +1 more source

Developmental Neurotoxicity of Trichlorfon in Zebrafish Larvae. [PDF]

Int J Mol Sci, 2023
Shi Q, Yang H, Chen Y, Zheng N, Li X, Wang X, Ding W, Zhang B.   +7 more
europepmc   +1 more source

Toward Predictable Nanomedicine: Current Forecasting Frameworks for Nanoparticle–Biology Interactions

Advanced Intelligent Discovery, EarlyView.
Predictive models successfully screen nanoparticles for toxicity and cellular uptake. Yet, complex biological dynamics and sparse, nonstandardized data limit their accuracy. The field urgently needs integrated artificial intelligence/machine learning, systems biology, and open‐access data protocols to bridge the gap between materials science and safe ...
Mariya L. Ivanova, Michael Nicholls, Nicola Russo, Gueorgui Mihaylov, Konstantin Nikolic   +4 more
wiley   +1 more source

2026 Update on the Management of Diffuse Large B‐Cell Lymphoma

American Journal of Hematology, EarlyView.
ABSTRACT Diffuse large B‐cell lymphoma (DLBCL) is the most common type of NHL in the Western Hemisphere. It comprises a heterogenous group of lymphomas, with different biology and clinical prognoses. R‐CHP remains the backbone of therapy, and frontline therapeutic options in fit patients are pola‐R‐CHP and R‐CHOP, whereas elderly or frail/unfit ...
Elise A. Chong, Emily B. Tomasulo, Stefan K. Barta   +2 more
wiley   +1 more source

Molecular mechanism of ischemic postconditioning in promoting diabetic ischemic brain injury repair via the microRNA‐34a–BDNF–SIX3 signaling axis

Animal Models and Experimental Medicine, EarlyView.
Diabetes combined with ischemic stroke (DMIS) exacerbates brain infarct size and neuronal damage compared to nondiabetic ischemic stroke (IS). This study reveals that microRNA‐34a (miR‐34a) plays a key role in DMIS pathogenesis: miR‐34a directly targets and suppresses brain‐derived neurotrophic factor (BDNF) and Sine oculis homeobox 3 (SIX3), promoting
Ling Zhao, Chunlan Zou, Junxian Li, Yang Yang, Yuanyuan Han, Tingyu Ke   +5 more
wiley   +1 more source

Human Brain Contusions Contain Pathogenic Transmissible Species that Induce Progressive Cognitive Decline and Tau Pathology in Mice

Annals of Neurology, EarlyView.
Objective Traumatic brain injury (TBI) is an established risk factor for dementia, although the underlying mechanisms remain unclear. Our previous research demonstrated that a single severe TBI in wild‐type (WT) mice induces a prion‐like form of tau (tauTBI) that spreads throughout the brain, leading to memory deficits.
Gloria Vegliante, Francesca Pischiutta, Elena Restelli, Federico Moro, Maria Antonietta Chiaravalloti, Ilaria Raimondi, Ilaria Bertani, Ilaria Lisi, Eliana Sammali, Rosaria Pascente, Serena Scozzari, Laura Pasetto, Carly Douglas, Marco Locatelli, Fabrizio Ortolano, Valentina Bonetto, David J. Loane, Nino Stocchetti, Roberto Chiesa, Elisa R. Zanier   +19 more
wiley   +1 more source

Genetic susceptibility to methylmercury developmental neurotoxicity matters

Frontiers in Genetics, 2013
Jordi eJulvez, Philippe eGrandjean
doaj   +1 more source