Results 201 to 210 of about 22,140 (237)

Weizmannia coagulans XY2 Mitigates Copper Neurotoxicity via Gut–Brain Axis Modulation of Tryptophan Metabolism and Oxidative‐Inflammatory Crosstalk

iMetaOmics, EarlyView.
Copper interferes with tryptophan metabolism and 5‐HT levels by modulating intestinal flora. Intestinal barrier breakdown and inflammatory response trigger nerve damage under copper exposure. W. coagulans XY2 alleviates copper‐induced neurotoxicity by targeting a multi‐dimensional “tryptophan metabolism‐antioxidant defense‐gut‐brain axis” network.
Yufang Gao, Xiaodong Zheng, Fujie Yan
wiley   +1 more source

Evaluation of Acephate Metabolites Generated by Zebrafish (Danio rerio) Using LC–HRMS and Metabolomics Approach

Journal of Applied Toxicology, EarlyView.
ABSTRACT Acephate is an organophosphate insecticide widely used. This pesticide can be metabolized into methamidophos, a molecule highly toxic. Both have demonstrated the ability to promote serious toxic effects on nontarget organisms and have been identified in surface waters around the world. Therefore, it is important to understand their behavior in
Mariana Laiz Silva de Lima, Lucas Rodrigues Cunha, Karina Taciana Santos Rubio, Maria Elvira Poleti Martucci   +3 more
wiley   +1 more source

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DEVELOPMENTAL NEUROTOXICITY TO METHAMPHETAMINES

Clinical and Experimental Pharmacology and Physiology, 1995
SUMMARY1. To investigate the long‐term changes caused by amphetamines in the developing brain, we used both an in vivo and in vitro model of chronic fetal exposure to methamphetamine and related drugs.2. Offspring of rats, treated with either saline, 2 mg/kg twice a day (b.i.d.) or 10 mg/kg bid. methamphetamine throughout gestation, were examined at 30
A D, Weissman, S, Caldecott-Hazard
openaire   +2 more sources

Oligodendroglia in Developmental Neurotoxicity

NeuroToxicology, 2003
The developing nervous system has been long recognized as a primary target for a variety of toxicants. To date, most efforts to understand the impact of neurotoxic agents on the brain have focused primarily on neurons and to a lesser degree astroglia as cellular targets.
Wenbin, Deng, Ronald D, Poretz
openaire   +2 more sources

Developmental Neurotoxicity: An Update

Journal of Neurosurgical Anesthesiology, 2019
In the section of “Developmental Neurotoxicity: An Update” of the Pediatric Anesthesia Neurodevelopmental Assessment (PANDA) symposium 2018 the speakers presented the current literature in translational and clinical research. Dr. Brambrink spoke about translational research in anesthetic neurotoxicity, beginning with discovery in the rodent model, then
Philipp J, Houck, Ansgar M, Brambrink, Jennifer, Waspe, James D, O'Leary, Riva, Ko   +4 more
openaire   +2 more sources

Update on developmental anesthesia neurotoxicity

Current Opinion in Anaesthesiology, 2017
(Curr Opin Anaesthesiol. 2017;30:337–342. doi: 10.1097/ACO.0000000000000461) For more than 60 years, the controversial association between anesthesia exposure in early postnatal life and behavioral or neurocognitive deficiency have been studied.
Vutskits, Laszlo, Davidson, Andrew
openaire   +3 more sources

Developmental Neurotoxicity of Lead

2017
Lead exposure is a major concern for the developing nervous system. Environmental exposures to lead, predominantly from contaminated water or lead paint chips, account for the majority of exposures to children. In utero and early life exposures to lead have been associated with lower IQ, antisocial and delinquent behaviors, and attention-deficit ...
Samuel, Caito, Michael, Aschner
openaire   +2 more sources

Epigenetic mechanisms in developmental neurotoxicity

Neurotoxicology and Teratology, 2018
The constant interplay between environment (including both exogenous and endogenous factors) and epigenome (defined as the combination of chromatin, its covalent modifications and noncoding RNAs) triggers epigenetic events that, by modulating gene expression, capture information about changes in the environment.
M, Raciti, S, Ceccatelli
openaire   +2 more sources

DEVELOPMENTAL CONSIDERATIONS OF NEUROTOXIC EXPOSURES

Neurologic Clinics, 2000
In this article, the authors provide a conceptual framework in which to consider alternative approaches to identify the developmental consequences of exposing the developing brain to neurotoxic substances. Concepts underlying brain development and issues regarding neurobehavioral testing in children are reviewed.
C L, Trask, B E, Kosofsky
openaire   +2 more sources

Developmental neurotoxicity of polybrominated biphenyls

Neurotoxicology and Teratology, 1994
Female F0 generation Sprague-Dawley rats received daily oral doses of 0, 0.2, or 2 mg/kg polybrominated biphenyls (PBB) as fireMaster BP-6 from Day 6 of gestation through Day 24 postpartum. Maternal parameters were assessed, and F1 generation offspring were evaluated for growth and survival, as well as physical and behavioral development.
J W, Henck, J L, Mattsson, D H, Rezabek, C L, Carlson, R H, Rech   +4 more
openaire   +2 more sources