Results 11 to 20 of about 275,688 (307)

Recent insights on indirect mechanisms in developmental toxicity of nanomaterials

Particle and Fibre Toxicology, 2020
Background Epidemiological and animal studies provide compelling indications that environmental and engineered nanomaterials (NMs) pose a risk for pregnancy, fetal development and offspring health later in life.
Battuja Batbajar Dugershaw, Leonie Aengenheister, Signe Schmidt Kjølner Hansen, Karin Sørig Hougaard, Tina Buerki-Thurnherr   +4 more
doaj   +1 more source

Permitted daily exposure for diisopropyl ether as a residual solvent in pharmaceuticals [PDF]

, 2018
Solvents can be used in the manufacture of medicinal products provided their residual levels in the final product comply with the acceptable limits based on safety data.
Evandri, Maria Grazia, Romanelli, Luca
core   +1 more source

The use of human induced pluripotent stem cells to screen for developmental toxicity potential indicates reduced potential for non-combusted products, when compared to cigarettes

Current Research in Toxicology, 2020
devTOX quickPredict (devTOXqP) is a metabolomics biomarker-based assay that utilises human induced pluripotent stem (iPS) cells to screen for potential early stage embryonic developmental toxicity in vitro.
Liam Simms, Kathryn Rudd, Jessica Palmer, Lukasz Czekala, Fan Yu, Fiona Chapman, Edgar Trelles Sticken, Roman Wieczorek, Lisa Maria Bode, Matthew Stevenson, Tanvir Walele   +10 more
doaj   +1 more source

Developmental and reproductive toxicity assessment in rats with KGC-HJ3, Korean Red Ginseng with Angelica gigas and Deer antlers

Journal of Ginseng Research, 2019
Background: Korean Red Ginseng has been widely used in traditional oriental medicine for a prolonged period, and its pharmacological effects have been extensively investigated.
Jinsoo Lee, Ji-Seong Jeong, Kyung-Jin Cho, Kyeong-Nang Moon, Sang Yun Kim, Byungcheol Han, Yong-Soon Kim, Eun Ju Jeong, Moon-Koo Chung, Wook-Joon Yu   +9 more
doaj   +1 more source

Conclusions of the French Food Safety Agency on the toxicity of bisphenol A [PDF]

, 2011
Since more than 10 years, risk assessment of bisphenol A (BPA) is debated at the international level. In 2008, the U.S. National Toxicology Program (NTP) expressed some concern for adverse effects, at current level of exposure to BPA, on developmental ...
Arnich, Nathalie, Canivenc-Lavier, Marie-Chantal, Coffigny, Hervé, Cravedi, Jean-Pierre, Grob, Konrad, Kolf-Clauw, Martine, Macherey, Anne-Christine, Masset, Dominique, Maximilien, Rémi, Narbonne, Jean-François, Nesslany, Fabrice, Stadler, Jeanne, Tulliez, Jacques   +12 more
core   +3 more sources

Casting a wide net: use of diverse model organisms to advance toxicology [PDF]

, 2020
© The Author(s), 2020. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Hahn, M. E., & Sadler, K. C. Casting a wide net: use of diverse model organisms to advance toxicology.
Hahn, Mark E., Sadler, Kirsten C.
core   +1 more source

Developmental Neurotoxicity and Behavioral Screening in Larval Zebrafish with a Comparison to Other Published Results

Toxics, 2022
With the abundance of chemicals in the environment that could potentially cause neurodevelopmental deficits, there is a need for rapid testing and chemical screening assays.
Kimberly A. Jarema, Deborah L. Hunter, Bridgett N. Hill, Jeanene K. Olin, Katy N. Britton, Matthew R. Waalkes, Stephanie Padilla   +6 more
doaj   +1 more source

In the Swim of Cannabis: Developmental Toxicity and Metabolomic Pathway Alterations of Zebrafish Larvae Exposed to THC for the Assessment of Its Potential Environmental and Human Health Impact

Molecules, 2022
As the pharmacological properties and therapeutic applications of Cannabis sativa L. pace with the upsurge of interest of the scientific community in harnessing its constituent phytocannabinoids, illicit use may raise serious health issues ...
Theodoros Chatzimitakos, Ieremias Chousidis, Dimitrios Leonardos, Constantine Stalikas, Ioannis Leonardos   +4 more
doaj   +1 more source

Developmental toxicity of combined ethylbenzene and methylethylketone administered by inhalation to rats [PDF]

, 2006
Pregnant Sprague–Dawley rats were exposed to ethylbenzene (EB; 0, 250, or 1000 ppm) and methylethylketone (MEK; 0, 1000, or 3000 ppm), alone and in combination, by inhalation, for 6 h/day, during days 6–20 of gestation.
Bourges-Abella, Nathalie, Cadot, R., Gallissot, Frédéric, Lambert, A.M., Morel, G., Sabaté, Jean-Philippe, Saillenfait, Anne-Marie   +6 more
core   +1 more source

Peroxisome Proliferator-Activated Receptors Alpha, Beta, and Gamma mRNA and Protein Expression in Human Fetal Tissues

PPAR Research, 2010
Peroxisome proliferator-activated receptors (PPARs) regulate lipid and glucose homeostasis, are targets of pharmaceuticals, and are also activated by environmental contaminants.
Barbara D. Abbott, Carmen R. Wood, Andrew M. Watkins, Kaberi P. Das, Christopher S. Lau   +4 more
doaj   +1 more source