Results 21 to 30 of about 515,791 (281)

Dexamethasone bovine pharmacokinetics [PDF]

European Journal of Drug Metabolism and Pharmacokinetics, 1991
Dexamethasone phosphate (DXM-PHO) is an ester which is quickly hydrolysed by the bovine and the dexamethasone (DXM) plasma half-life was 5.16 h. It has been demonstrated that 54 h after DXM-PHO injection, DXM concentrations were lower than 0.1 mg/ml.
Gaignage, Ph, Lognay, Georges C., Bosson, Danièle, Vertongen, D., Dreze, Ph, Marlier, Michel, Severin, Michel   +6 more
openaire   +2 more sources

Dexamethasone vs methylprednisolone high dose for Covid-19 pneumonia

PLoS ONE, 2021
Background There is no effective therapy for the severe acute respiratory syndrome by coronavirus 2 (SARS-CoV2) responsible for the Coronavirus disease 2019 (Covid-19).
M. Pinzón, S. Ortiz, Héctor Holguín, J. Betancur, Doris Cardona Arango, Henry Laniado, Carolina Arias Arias, B. Muñoz, Julián Quiceno, Daniel Jaramillo, Zoraida Ramirez   +10 more
semanticscholar   +1 more source

Dexamethasone Improves Cardiovascular Outcomes in Critically Ill COVID-19, a Real World Scenario Multicenter Analysis

Frontiers in Medicine, 2022
BackgroundSevere COVID-19 pneumonia requiring intensive care treatment remains a clinical challenge to date. Dexamethasone was reported as a promising treatment option, leading to a reduction of mortality rates in severe COVID-19 disease.
Peter Jirak, Vincent van Almsick, Dimitrios Dimitroulis, Moritz Mirna, Clemens Seelmaier, Zornitsa Shomanova, Bernhard Wernly, Bernhard Wernly, Bernhard Wernly, Dilvin Semo, Daniel Dankl, Magdalena Mahringer, Michael Lichtenauer, Uta C. Hoppe, Holger Reinecke, Rudin Pistulli, Robert Larbig, Robert Larbig, Lukas J. Motloch   +18 more
doaj   +1 more source

Immune and ionic mechanisms mediating the effect of dexamethasone in severe COVID-19

Frontiers in Immunology, 2023
IntroductionSevere COVID-19 is characterized by cytokine storm, an excessive production of proinflammatory cytokines that contributes to acute lung damage and death.
Ameet A. Chimote, Abdulaziz O. Alshwimi, Martina Chirra, Vaibhavkumar S. Gawali, Margaret V. Powers-Fletcher, Kristin M. Hudock, Kristin M. Hudock, Laura Conforti   +7 more
doaj   +1 more source

Dexamethasone sensitizes to ferroptosis by glucocorticoid receptor–induced dipeptidase-1 expression and glutathione depletion

Science Advances, 2022
Dexamethasone is widely used as an immunosuppressive therapy and recently as COVID-19 treatment. Here, we demonstrate that dexamethasone sensitizes to ferroptosis, a form of iron-catalyzed necrosis, previously suggested to contribute to diseases such as ...
Anne von Mässenhausen, Nadia Zamora Gonzalez, F. Maremonti, A. Belavgeni, W. Tonnus, C. Meyer, Kristina Beer, M. Hannani, A. Lau, M. Peitzsch, Paul Hoppenz, S. Locke, T. Chavakis, R. Kramann, D. Muruve, C. Hugo, S. Bornstein, A. Linkermann   +17 more
semanticscholar   +1 more source

Analysis of renal impairment in MM-003, a phase III study of pomalidomide + low - dose dexamethasone versus high - dose dexamethasone in refractory or relapsed and refractory multiple myeloma

Haematologica, 2016
Pomalidomide + low-dose dexamethasone is effective and well tolerated for refractory or relapsed and refractory multiple myeloma after bortezomib and lenalidomide failure.
Katja C. Weisel, Meletios A. Dimopoulos, Philippe Moreau, Martha Q. Lacy, Kevin W. Song, Michel Delforge, Lionel Karlin, Hartmut Goldschmidt, Anne Banos, Albert Oriol, Adrian Alegre, Christine Chen, Michele Cavo, Laurent Garderet, Valentina Ivanova, Joaquin Martinez-Lopez, Stefan Knop, Xin Yu, Kevin Hong, Lars Sternas, Christian Jacques, Mohamed H. Zaki, Jesus San Miguel   +22 more
doaj   +1 more source

Dexamethasone and Surgical-Site Infection.

New England Journal of Medicine, 2021
BACKGROUND The glucocorticoid dexamethasone prevents nausea and vomiting after surgery, but there is concern that it may increase the risk of surgical-site infection.
T. Corcoran, P. Myles, A. Forbes, A. Cheng, L. Bach, E. O’Loughlin, K. Leslie, M. Chan, D. Story, T. Short, Catherine A Martin, P. Coutts, K. Ho   +12 more
semanticscholar   +1 more source

BMP2 and TGF-β Cooperate Differently during Synovial-Derived Stem-Cell Chondrogenesis in a Dexamethasone-Dependent Manner [PDF]

, 2019
Recent studies highlighting mesenchymal stem cell (MSC) epigenetic memory suggest that a different differentiation medium may be required depending on the tissue of origin.
Alini, Mauro, Basoli, Valentina, Della Bella, Elena, Kovermann, Nikolas J., Kubosch, Eva Johanna, Lischer, Christoph, Schmal, Hagen, Stoddart, Martin J.   +7 more
core   +1 more source

Optimizing adipogenic transdifferentiation of bovine mesenchymal stem cells: a prominent role of ascorbic acid in FABP4 induction [PDF]

, 2020
Adipocyte differentiation of bovine adipose-derived stem cells (ASC) was induced by foetal bovine serum (FBS), biotin, pantothenic acid, insulin, rosiglitazone, dexamethasone and 3-isobutyl-1-methylxanthine, followed by incubation in different media to ...
Aschenbach, Jörg R., Bermúdez- Peña, M. Carmen, Jurek, Sandra, Kolisek, Martin, Sandhu, Mansur A., Sponder, Gerhard, Trappe, Susanne   +6 more
core   +1 more source

Dexamethasone enhances osteogenic differentiation of bone marrow- and muscle-derived stromal cells and augments ectopic bone formation induced by bone morphogenetic protein-2. [PDF]

PLoS ONE, 2015
UNLABELLED:We evaluated whether dexamethasone augments the osteogenic capability of bone marrow-derived stromal cells (BMSCs) and muscle tissue-derived stromal cells (MuSCs), both of which are thought to contribute to ectopic bone formation induced by ...
Masato Yuasa, Tsuyoshi Yamada, Takashi Taniyama, Tomokazu Masaoka, Wei Xuetao, Toshitaka Yoshii, Masaki Horie, Hiroaki Yasuda, Toshimasa Uemura, Atsushi Okawa, Shinichi Sotome   +10 more
doaj   +1 more source