Real-time evaluation of the independent analgesic efficacy of dexmedetomidine
BMC Anesthesiology, 2023 Background Dexmedetomidine has analgesic properties, but the intraoperative analgesic effect of dexmedetomidine is often masked by the effects of other general anaesthetics.
XiaoHua Wang +6 more
doaj +1 more source
High-throughput screening in larval zebrafish identifies novel potent sedative-hypnotics [PDF]
, 2018 BACKGROUND: Many general anesthetics were discovered empirically, but primary screens to find new sedative-hypnotics in drug libraries have not used animals, limiting the types of drugs discovered.
Brown, Lauren E. +12 more
core +1 more source
BMC Anesthesiology, 2020 Background Sepsis often accompanies gastrointestinal motility disorder that contributes to the development of sepsis in turn. Propofol and dexmedetomidine, as widely used sedatives in patients with sepsis, are likely to depress gastrointestinal ...
Haiqing Chang +9 more
doaj +1 more source
Relationship between dexmedetomidine dose and plasma dexmedetomidine concentration in critically ill infants: a prospective observational cohort study [PDF]
Korean Journal of Anesthesiology, 2017 BackgroundDexmedetomidine is a highly selective central α2-agonist used as a sedative in pediatric intensive care unit (PICU). However, little is known about the relationship between dexmedetomidine dose and its plasma concentration during long-term ...
Yoshihito Fujita +6 more
doaj +1 more source
Prevention of acute kidney injury and protection of renal function in the intensive care unit : update 2017 [PDF]
, 2017 Background: Acute kidney injury (AKI) in the intensive care unit is associated with significant mortality and morbidity. Objectives: To determine and update previous recommendations for the prevention of AKI, specifically the role of fluids, diuretics ...
Druml, W +8 more
core +3 more sources
In Vitro Effect of Dexmedetomidine on Platelet Aggregation
Brazilian Journal of Anesthesiology, 2013 Background and objectives: : Dexmedetomidine is a selective α2-agonist. There are 250-300 α2- adrenoceptor on the surface of each human platelet and ephedrine induces platelet aggregation by binding these receptors.
Emine Arzu Kose +3 more
doaj +1 more source
Sedative and Immunosuppressive Effects of Dexmedetomidine in Transplantation
Pharmaceuticals, 2021 Dexmedetomidine, an α2-adrenergic receptor agonist, is used as an anti-anxiety medication. It exerts a cholinergic effect, thereby reducing the release of tumor necrosis factor alpha (TNF-α).
Chen-Fang Lee +9 more
doaj +1 more source
Frontiers in Pharmacology, 2022 Background and Purpose: There are many benefits of administering dexmedetomidine perioperatively. The pharmacokinetics (PK) and pharmacodynamics (PD) of intravenous, intranasal and oral dexmedetomidine that was administered before anesthesia were ...
Jinhong Wu +5 more
doaj +1 more source
Dexmedetomidine post-treatment attenuates cardiac ischaemia/reperfusion injury by inhibiting apoptosis through HIF-1α signalling. [PDF]
, 2020 Hypoxia-inducible factor 1α (HIF-1α) plays a critical role in the apoptotic process during cardiac ischaemia/reperfusion (I/R) injury. This study aimed to investigate whether post-treatment with dexmedetomidine (DEX) could protect against I/R-induced ...
Chen, Wei-Rong +8 more
core
Electroencephalogram Mechanism of Dexmedetomidine Deepening Sevoflurane Anesthesia
Frontiers in Neuroscience, 2022 Dexmedetomidine, as an α2-adrenoceptor agonist, plays anti-sympathetic, sedative and analgesic roles in perioperative period. Also, dexmedetomidine can reduce the minimal alveolar concentration (MAC) of sevoflurane and the risk of postoperative cognitive
Lei Zhang +15 more
doaj +1 more source