Results 21 to 30 of about 69,499 (314)

Prevention of acute kidney injury and protection of renal function in the intensive care unit : update 2017 [PDF]

, 2017
Background: Acute kidney injury (AKI) in the intensive care unit is associated with significant mortality and morbidity. Objectives: To determine and update previous recommendations for the prevention of AKI, specifically the role of fluids, diuretics ...
Druml, W, Forni, LG, Groeneveld, ABJ, Honore, PM, Hoste, Eric, Joannidis, M, Ostermann, M, Oudemans-van Straaten, HM, Schetz, Mathias   +8 more
core   +3 more sources

Real-time evaluation of the independent analgesic efficacy of dexmedetomidine

BMC Anesthesiology, 2023
Background Dexmedetomidine has analgesic properties, but the intraoperative analgesic effect of dexmedetomidine is often masked by the effects of other general anaesthetics.
XiaoHua Wang, SiYuan Zhang, Chunxiu Wang, Yi Huang, Hao Wu, Guoguang Zhao, TianLong Wang   +6 more
doaj   +1 more source

High-throughput screening in larval zebrafish identifies novel potent sedative-hypnotics [PDF]

, 2018
BACKGROUND: Many general anesthetics were discovered empirically, but primary screens to find new sedative-hypnotics in drug libraries have not used animals, limiting the types of drugs discovered.
Brown, Lauren E., Dai, Jennifer B., Daigle, Renee, Forman, Stuart A., Halpin, Elizabeth S., Jounaidi, Youssef, Marte-Oquendo, Francisco, Porco, John A., Schaus, Scott E., Trilles, Richard, Xu, Wenqing, Yang, Xiaoxuan, Yu, Buwei   +12 more
core   +1 more source

Effect of intraoperative dexmedetomidine infusion during functional endoscopic sinus surgery: a prospective cohort study

Patient Safety in Surgery, 2020
Background Dexmedetomidine, an α2 agonist, has well-known anesthetic and analgesic-sparing effects. We designed this study to evaluate the effect of intraoperative dexmedetomidine infusion on intra operative blood loss and postoperative pain in ...
Mohammad Reza Fazel, Zeynab Sadat Ahmadi, Hossein Akbari, Fahimeh Abam   +3 more
doaj   +1 more source

Medication Complications in Extracorporeal Membrane Oxygenation. [PDF]

, 2017
The need for extracorporeal membrane oxygenation (ECMO) therapy is a marker of disease severity for which multiple medications are required. The therapy causes physiologic changes that impact drug pharmacokinetics.
Aebi, Ami G. Shah, Anderson, Arlt, Barr, Barthelemy, Beiderlinden, Bein, Bembea, Bhatt-Meht, Boucher, Brandi N. Thoma, Brown, Buck, Buscher, Chung, Dagan, Dagan, de Montmollin, De Rosa, DeGrado, Donadello, Donadello, Dzierba, Erstad, Esper, Eyler, Flordelis Lasierra, Glauber, Greenberg, Gélisse, Hadidi, Hertzog, Hraiech, Hynynen, Johnston, Kawada, Kim, Koster, Krueger, Lamarche, Latronico, Lemaitre, Levison, Malfertheiner, Mehta, Michelle Peahota, Moore, Mousavi, Mulla, Mulla, Muntean, Oliver, Paden, Park, Perkins, Peters, Pettignano, Phillips, Pieri, Potter, Preston, Protti, Ranucci, Riker, Roberts, Roos, Rosen, Ruiz, Rybak, Saini, Sanfilippo, Satyapriya, Schmith, Shekar, Shekar, Shekar, Shekar, Shekar, Sherwin, Sklar, Smith, Spriet, Staudacher, Strunk, Subramaniam, Szefner, Tellor, Trudzinski, Tulman, Turner, Veinstein, Vilay, Wagner, Walter K. Kraft, Welsch, Wen, Wildschut, Wu, Young   +99 more
core   +2 more sources

Effect of sedation with dexmedetomidine or propofol on gastrointestinal motility in lipopolysaccharide-induced endotoxemic mice

BMC Anesthesiology, 2020
Background Sepsis often accompanies gastrointestinal motility disorder that contributes to the development of sepsis in turn. Propofol and dexmedetomidine, as widely used sedatives in patients with sepsis, are likely to depress gastrointestinal ...
Haiqing Chang, Shuang Li, Yansong Li, Hao Hu, Bo Cheng, Jiwen Miao, Hui Gao, Hongli Ma, Yanfeng Gao, Qiang Wang   +9 more
doaj   +1 more source

Dose rationale and pharmacokinetics of dexmedetomidine in mechanically ventilated new-borns : impact of design optimisation [PDF]

, 2019
Purpose: There is a need for alternative analgosedatives such as dexmedetomidine in neonates. Given the ethical and practical difficulties, protocol design for clinical trials in neonates should be carefully considered before implementation.
Allegaert, Karel, De Cock, Pieter, De Paepe, Peter, Decaluwe, Wim, Della Pasqua, Oscar, Smets, Koenraad, Smits, Anne, van Dijkman, Sven C, Vande Walle, Johan   +8 more
core   +5 more sources

In Vitro Effect of Dexmedetomidine on Platelet Aggregation

Brazilian Journal of Anesthesiology, 2013
Background and objectives: : Dexmedetomidine is a selective α2-agonist. There are 250-300 α2- adrenoceptor on the surface of each human platelet and ephedrine induces platelet aggregation by binding these receptors.
Emine Arzu Kose, Oral Nevruz, Mehtap Honca, Vedat Yildirim   +3 more
doaj   +1 more source

Perioperative Low Dose Dexmedetomidine and Its Effect on the Visibility of the Surgical Field for Middle Ear Microsurgery: A Randomised Controlled Trial

Frontiers in Pharmacology, 2022
Background and Purpose: There are many benefits of administering dexmedetomidine perioperatively. The pharmacokinetics (PK) and pharmacodynamics (PD) of intravenous, intranasal and oral dexmedetomidine that was administered before anesthesia were ...
Jinhong Wu, Yuan Han, Yu Lu, Yan Zhuang, Wenxian Li, Ji’e Jia   +5 more
doaj   +1 more source

Dexmedetomidine post-treatment attenuates cardiac ischaemia/reperfusion injury by inhibiting apoptosis through HIF-1α signalling. [PDF]

, 2020
Hypoxia-inducible factor 1α (HIF-1α) plays a critical role in the apoptotic process during cardiac ischaemia/reperfusion (I/R) injury. This study aimed to investigate whether post-treatment with dexmedetomidine (DEX) could protect against I/R-induced ...
Chen, Wei-Rong, Ji, Fu-Hai, Liu, Hong, Liu, Hua-Yue, Meng, Xiao-Wen, Peng, Ke, Xia, Fan, Xia, Zheng-Yuan, Zhang, Juan   +8 more
core