Results 251 to 260 of about 305,495 (322)

Targeting WTAP/ROR1/WNT5A‐Mediated Crosstalk Between Glioma Stem Cells and Macrophages to Normalize Tumor Vasculature and Enhance Chemotherapy

Advanced Science, EarlyView.
In hypoxic microenvironment, WNT5A is predominantly secreted by tumor‐associated macrophages. Hypoxia‐induced WTAP mediates ROR1 stability by m6A modifications in a HuR‐dependent manner in Glioma stem cells (GSCs). WNT5A activates the WNT pathway via ROR1 binding on GSCs, driving glioma‐derived endothelial cells (GDECs) differentiation.
Xiaoyong Chen, Bo Pang, Yun Liu, Jiangwei Wang, Lanhui Zheng, Yuzhou Chang, Yingxuan Sun, Haoyuan Sun, Huiyuan Chen, Jiawei Cai, Zanyi Wu, Qing Chang, Yongzhi Wang, Dezhi Kang, Tao Jiang, Ruichao Chai   +15 more
wiley   +1 more source

Abnormal neurovascular coupling induces glymphatic dysfunction in a mouse model of familial hemiplegic migraine type 2. [PDF]

J Headache Pain
Duan C, Wu S, Li Y, Zhang K, Lin C, Yao Y, Wang T, Wang Y.   +7 more
europepmc   +1 more source

A Prussian Blue Nanozyme‐Adjuvanted Vaccine Presenting Phosphocholine Antigens for Induction of Immunotolerance in Inflammatory Bowel Disease

Advanced Science, EarlyView.
ABSTRACT Inflammatory bowel disease (IBD) is a complex disorder characterized by chronic intestinal inflammation and impaired barrier function, for which effective long‐term therapies remain elusive. To address this challenge, we developed a novel nano‐vaccine that combines Prussian blue nanozymes (PBNZs) adjuvants with a ferritin carrier loaded with ...
Jingyi Sheng, Yubo Huang, Xinyue Li, Yin Liu, Yuehuang Wu, Yuxin Zhang, Ning Gu   +6 more
wiley   +1 more source

Systematic Development and Characterization of Enzyme-Free, Borax-Crosslinked Microneedles for Glucose-Responsive Insulin Delivery and In Vivo Glycemic Mitigation. [PDF]

Pharmaceutics
Dinh CT, Nguyen LP, Pham UT, Nguyen AM, Do HTM, Tran TQ, Luu PD, Doan TD, Bui MTH, Nguyen DT.   +9 more
europepmc   +1 more source

Disentangling Coincident Cell Events Using Deep Transfer Learning and Compressive Sensing

Advanced Intelligent Systems, EarlyView.
Overlapping cells during detection distort single‐cell measurements and reduce diagnostic accuracy. A hybrid framework combining a fully convolutional neural network with compressive sensing to disentangle overlapping signals directly from raw time‐series data is presented.
Moritz Leuthner, Rafael Vorländer, Oliver Hayden   +2 more
wiley   +1 more source

Permeability-driven pressure and cell proliferation control lumen morphogenesis in pancreatic organoids. [PDF]

Nat Cell Biol
Lee BH, Fuji K, Petzold H, Seymour P, Yennek S, Schewin C, Lewis A, Riveline D, Hiraiwa T, Sano M, Grapin-Botton A.   +10 more
europepmc   +1 more source

Development of an in situ small intestinal injection technique for targeted macromolecule delivery and in vivo functional studies in mice

Animal Models and Experimental Medicine, EarlyView.
This study developed a minimally invasive, in situ small intestinal injection technique for mice, enabling targeted delivery of bioactive molecules while bypassing gastric degradation. Validation using functional assays and single‐cell RNA sequencing reveals high‐mobility group box 1–mediated epithelial responses, offering a translational tool for gut ...
Yawen Lai, Xintao Zhang, Tingting Luo, Wenhan Chen, Chenyu Ma, Haihua Luo, Jinghua Liu, Jia Xu   +7 more
wiley   +1 more source

Diurnal behavioral outcomes and BBB integrity in adult male SHR and WKY rats. [PDF]

Sci Rep
Shrivastava P, Biose OD, Dahal R, Jwayyed A, Raji RA, Xia H, Lazartigues E, Biose IJ.   +7 more
europepmc   +1 more source

Implantable Drug Delivery Systems for Skeletal Muscles and Eyes

Advanced NanoBiomed Research, EarlyView.
This review highlights the different types of recent implantable drug delivery systems (IDDS) fabricated for a use with skeletal muscles, and with eyes. It presents the developments already made and the current research directions, showing the evolution of IDDS and their great diversity.
Serge Ostrovidov, Murugan Ramalingam, Hongkai Wu, Toshinori Fujie, Yukinari Nakamura, Takeshi Hori, Yuji Nashimoto, Xuetao Shi, Hirokazu Kaji   +8 more
wiley   +1 more source

Assessment of permeability in deep tissue capillaries using a new method reflects the nutrient supply status in a healthy heart. [PDF]

Regen Ther
Nakamura M, Yoshida-Kikkawa Y, Sugiura K, Itakura Y, Ohse K, Sasaki N, Ito Y, Toyoda M.   +7 more
europepmc   +1 more source