Results 261 to 270 of about 302,965 (344)

CU104, a novel barrier function enhancer, improves colitis via modulation of barrier function and immune cell recruitment. [PDF]

Front Immunol
Park IS, Kim JH, Kim D, Kim YW, Shin Y, Kim KB, Zhang H, Kim TI, Kim SW, Kwon YG, Cheon JH.   +10 more
europepmc   +1 more source

Advanced nanotherapeutics for combating ocular infections: Rational design, antimicrobial mechanisms, and therapeutic breakthroughs

BMEMat, EarlyView.
Nanomaterials revolutionize ocular infection treatment by enabling targeted drug delivery and enhanced antimicrobial efficacy against resistant pathogens. This review systematically explores their rational design, multimodal mechanisms, and translational potential for next‐generation anti‐infective therapies.
Yujia Liu, Xuetian Wen, Yue Tan, Rui Zeng, Yijuan Zhang, Tong Lin, Lan Gong, Zichao Luo   +7 more
wiley   +1 more source

A stress-responsive neurovascular axis shapes skin immune accessibility. [PDF]

iScience
Yu Y, Su R, Wang W, Yang Y, Huang H, Du Y, Lu Y, Fan Y, Li J, Chen T.   +9 more
europepmc   +1 more source

Water-soluble propolis ameliorates dextran sodium sulfate-induced colitis in mice via NF-κB pathway-induced inflammation suppression

Chan-gyu Park, Ji-Hyeon Park, Jae-Young Shin, Mi-Yeung Kim, Guiyu Song, Yong-Kap Hur, Seon Il Jang, Byoung Ok Cho   +7 more
openalex   +1 more source

A nanoplatform that induces dual‐amino acid deprivation to reverse tumor immunosuppression and enhance metabolic immunotherapy

BMEMat, EarlyView.
ZIF‐8‐based nanoparticles co‐delivering CB‐839 (glutaminase inhibitor) and 1‐MT (IDO1 inhibitor), dual‐targeting glutamine/tryptophan metabolism to induce immunogenic cell death, activate STING, block kynurenine production, reverse immunosuppression, and enhance cancer immunotherapy to suppress primary/distant tumors.
Wenli Ning, Yunhan Sun, Mingyang Li, Shilu Liu, Fangjie Yi, Hongfei Wang, Ruibing Bai, Dongdong Liu, Fen Zhao, Guiqiang Zhang, Xiao Fu   +10 more
wiley   +1 more source

Dextran-modified dissolving microneedle patches for effective amelioration of psoriasis through transdermal delivery of hesperidin. [PDF]

Int J Pharm X
Etemadi N, Varshosaz J, Shamaeizadeh N, Renani AM, Minaiyan M.   +4 more
europepmc   +1 more source

Transfersomes with core and surface‐loaded NF‐κB p65 siRNA for enhanced transdermal transfection and effective treatment of psoriasis

BMEMat, EarlyView.
TCPL, a transfersome with Tween 80 and PEI, enables efficient transdermal siNF‐κB delivery, resolving PEI's toxicity issue. It promotes lysosomal escape and effective transfection, silences NF‐κB, modulates immunity, and inhibits angiogenesis, alleviating psoriasis. With good biocompatibility, TCPL holds strong clinical translation potential. Schematic
Hui Xing, Yuhui Yang, Ziyi Zhao, Kai Lv, Yiran Shao, Zhi Zhang, Dong Ma   +6 more
wiley   +1 more source

Oxidized Dextran/Carboxymethyl Chitosan Dynamic Schiff-Base Hydrogel for Sustained Hydrogen Sulfide Delivery and Burn Wound Microenvironment Remodeling. [PDF]

Pharmaceutics
Liu Z, Zhu Y, Ma Z, Ning X, Zhou Z, Liu J, Xie Y, Li G, Hu P.   +8 more
europepmc   +1 more source

The ageing holobiont: crosstalk between telomere dynamics, oxidative stress and the gut microbiome

Biological Reviews, EarlyView.
ABSTRACT The gut tissue is at the frontline of early onset of ageing. It exhibits high cell turnover rates and rapid telomere shortening, which can have systemic effects on the developing or senescing organism. We conducted a literature review of studies on the crosstalk between telomere length dynamics, telomerase activity, oxidative stress, and gut ...
Michael L. Pepke, Søren B. Hansen, Morten T. Limborg   +2 more
wiley   +1 more source