Results 101 to 110 of about 64,315 (292)

Ciclopirox Olamine Inhibits the NLRP3 Inflammasome to Alleviate Inflammatory Diseases

Advanced Science, EarlyView.
There is no drug targeting the NLRP3 inflammasome that has been approved for use in clinical settings. Ciclopirox olamine (CPX), an antifungal agent approved by the US Food and Drug Administration (FDA), is identified as a specific and potent NLRP3 inflammasome inhibitor. CPX targets the NACHT domain of NLRP3 at Y381 to impair NLRP3 oligomerization and
Xinyu Xia, Hui You, Ke Zhang, Hui Jiang, Hongping Liu, Lianghua Liu, Aijie Zhang, You Zhou   +7 more
wiley   +1 more source

Comparison of Pharmaceutical Properties of Dextran Sulfate Sodium Tablets

Japanese Journal of Hospital Pharmacy, 1976
Fourteen brands of dextran sulfate sodium (DS-Na) tablets of 11 manufacturers (7 brands in sugar-coated tablet and remaining 7 in film-coated tablet) were tested on their pharmaceutical characteristics, heat resistance, moisture resistance and disintegration.
TAKATORI, KICHITARO, NAKANO, SUEHARU, HASEGAWA, TAKAAKI   +2 more
openaire   +2 more sources

PATOFISIOLOGI KOLITIS YANG DIINDUKSI DEXTRAN SODIUM SULFAT

Ibnu Sina: Jurnal Kedokteran dan Kesehatan - Fakultas Kedokteran Universitas Islam Sumatera Utara, 2021
Penyakit Radang Usus atau Intestinal Bowel Diseases (IBD) terutama terdiri dari Kolitis Ulserativa dan penyakit Crohn merupakan penyakit kompleks hasil dari respon imun kronis yang tidak teratur di saluran pencernaan dan multifaktorial dengan etiologi pastinya tidak diketahui. Untuk menyelidiki patogenesis dan etiologi IBD manusia, berbagai hewan model
openaire   +1 more source

SSR4 sustains Tertiary Lymphoid Structures by Regulation Quality Control of N‐linked Glycosylation During B‐cell Differentiation Into Plasmacyte in Colorectal Cancer

Advanced Science, EarlyView.
SSR4, a TRAP component induced in B cells, governs BAFFR N‐glycosylation via DDOST to sustain NF‐κB signaling, B‐cell differentiation, and TLS maturation. Its loss impairs anti‐tumor immunity, while overexpression improves antibody glycosylation and ADCC, revealing a critical regulator for cancer immunotherapy.
Wei Zhao, Youcai Zhao, Haiyang Li, Bowen Yang, Siyan Lu, Xueting Fu, Caixia Zhang, Yirong Chen, Xiaofeng Bian, Xinghua Ma, Xiaobing Yang, Bin Wang, Yuan Fang, Lulu Yang, Yelin Zhao, Shuli Zhao   +15 more
wiley   +1 more source

Stabilizing Water-in-Water Emulsions Using Oil Droplets

Molecules
The production of water-in-water emulsion droplets, the coalescence of which is prevented by adding oil-in-water micrometric droplets, is reported. Hexadecane (O) and cetyl trimethyl ammonium bromide (CTAB) were added to a W/W emulsion made of dextran ...
Jean-Paul Douliez, Laure Béven
doaj   +1 more source

Synbiotics suppress colitis-induced tumorigenesis in a colon-specific cancer mouse model.

PLoS ONE, 2019
Although synbiotics may be effective in maintaining remission of inflammatory bowel disease, their anticarcinogenic effects are still debated. To address this issue, we evaluated the effects of synbiotics, probiotics, and prebiotics on tumorigenesis ...
Yasufumi Saito, Takao Hinoi, Tomohiro Adachi, Masashi Miguchi, Hiroaki Niitsu, Masatoshi Kochi, Haruki Sada, Yusuke Sotomaru, Naoya Sakamoto, Kazuhiro Sentani, Naohide Oue, Wataru Yasui, Hirotaka Tashiro, Hideki Ohdan   +13 more
doaj   +1 more source

Supplemental_data – Supplemental material for Is dextran sulfate sodium a good inducer of acute experimental enteritis?

, 2019
Supplemental material, Supplemental_data for Is dextran sulfate sodium a good inducer of acute experimental enteritis? by Wei Chen, Jing Zhang, Chen Li, Quan Pan, Jingtong Wu, Lina Fan, Chunyan Chen, Xiaoqing Huang, Fei Teng and Jinshui Zhu in ...
Xiaoqing Huang (753291), Quan Pan (6495497), Fei Teng (201085), Lina Fan (2211169), Jingtong Wu (6579818), Jing Zhang (23775), Chunyan Chen (95808), Chen Li (54018), Wei Chen (23863), Jinshui Zhu (4428487)   +9 more
core   +1 more source

Multi‐Component Functionalized Bifidobacterium Longum Hydrogel for Multi‐Target Integrated Therapy of Colitis‐Associated Anxiety and Depression

Advanced Science, EarlyView.
A pH/MMP dual‐responsive Bifidobacterium longum (BL) hydrogel (INPs@BL@Gel) functionalized with baicalin, tyrosine, and inulin is constructed. It enables gastric protection, inflammation‐targeted release, and prolonged intestinal colonization. By remodeling gut microbiota, elevating beneficial neuroactive metabolites (homovanillic acid, short‐chain ...
Shuo Zhang, Yujie Zhang, Jiansheng He, Shunlian Li, Qingyan Ma, Qiao Li, Yudan Zhang, Yiyang Wang, Shaobo Ma, Songyan Jin, Chune Li, Xueyong Xie, Hang Zhang, Junze Deng, Xueqin Song, Daocheng Wu, Xiancang Ma, Feng Zhu   +17 more
wiley   +1 more source

Nano‐Backpack Engineered Probiotics with Reactive Oxygen Species–Responsive Tungsten Release for Synergistic Therapy of Inflammatory Bowel Disease

Advanced Science, EarlyView.
An integrated probiotic system is engineered to execute a programmed therapeutic cascade against inflammatory bowel disease. Upon pathological signals, the system sequentially performs ROS scavenging, tungsten release, and selective pathogen suppression, thereby breaking the oxidative stress–dysbiosis cycle to remodel gut microbiota and reinforce ...
Yang Yang, Liucan Wang, Guoqing Chen, Yuanling Zhang, Jiarui Shi, Wenzhe Fan, Min Yu, Jixi Zhang, Hua Yang   +8 more
wiley   +1 more source

S100A8/A9‐High Macrophages Activate Intestinal Fibroblasts via mCCL6/hCCL15‐CCR1 Axis to Drive Intestinal Fibrosis in Crohn's Disease

Advanced Science, EarlyView.
S100A8/A9‐high macrophages are markedly enriched in the stenotic intestinal tissue of patients with Crohn's disease. These profibrotic macrophages secrete mCCL6 in a STAT3‐dependent manner. mCCL6 and its human ortholog hCCL15 activate fibroblasts via the CCR1 receptor, thereby driving excessive collagen deposition.
Shu Wang, Jiayun Wang, Junjie Lin, Ziping Ye, Geyujia Zhou, Jingjing Ma, Junjian Sun, Jiang Yu, Yingdi Zhang, Nana Tang, Chunhua Jiao, Xiaojing Zhao, Hongjie Zhang   +12 more
wiley   +1 more source