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Lactobacillus fermentum BR11, a potential new probiotic, alleviates symptoms of colitis induced by dextran sulfate sodium (DSS) in rats

International Journal of Food Microbiology, 2007
Current treatments for inflammatory bowel disease (IBD) are relatively ineffective. Recently, probiotics have emerged as a potential treatment modality for numerous gastrointestinal disorders, including IBD.
Mark S Geier, Philip M Giffard, Gordon S Howarth   +2 more
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Induction of Colitis in Young Rats by Dextran Sulfate Sodium

Digestive Diseases and Sciences, 2005
Models using dextran sulfate sodium (DSS) to induce experimental colitis in rodents have been performed mostly in adult animals. For this reason, we aimed to develop a model of colitis in young rats. DSS was administered to 30-day-old rats at concentrations ranging from 0.5 to 5% in drinking water.
María, Vicario, Mar, Crespí, Angels, Franch, Concepció, Amat, Carme, Pelegrí, Miquel, Moretó   +5 more
openaire   +3 more sources

Dextran Sulfate Sodium-Induced Colitis in Immunodeficient Rats

Digestive Diseases and Sciences, 2000
To examine the morphology of colitis and study the role of the immune system in colitis, we compared colitis in immunocompetent Wistar-Kyoto rats with that in spontaneously hypertensive rats, known to have T-cell dysfunction. Rats were treated with 3% dextran sulfate in drinking water for periods ranging from 3 to 60 days.
K, Shichijo, M, Gottfried, I, Sekine, T N, Pappas   +3 more
openaire   +2 more sources

Effect of Heparin on Dextran Sulfate Sodium-Induced Colitis

Digestive Diseases and Sciences, 1998
Heparin has been shown to ameliorate inflammatory bowel disease in several series. In addition to its anticoagulant properties, heparin has numerous other effects that may be beneficial in inflammatory bowel disease. Other sulfated polysaccharides, such as dextran sulfate, cause colitis in mice through unknown mechanisms.
J R, Korzenik, A, Hsu, M E, Robert
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The Severity of Dextran Sodium Sulfate-Induced Colitis Can Differ Between Dextran Sodium Sulfate Preparations of the Same Molecular Weight Range

Digestive Diseases and Sciences, 2011
We hypothesized that the severity of dextran sodium sulfate (DSS)-induced colitis could differ between DSS preparations of the same molecular weight, and that this difference may be affected by the sulfur content. To test this, we used three DSS preparations of similar molecular weights but with different sulfur contents.Three DSS preparations with ...
Shigeki, Bamba, Akira, Andoh, Hiromitsu, Ban, Hirotsugu, Imaeda, Tomoki, Aomatsu, Ayako, Kobori, Yosuke, Mochizuki, Makoto, Shioya, Takashi, Nishimura, Osamu, Inatomi, Masaya, Sasaki, Yasuharu, Saitoh, Tomoyuki, Tsujikawa, Yoshio, Araki, Yoshihide, Fujiyama   +14 more
openaire   +2 more sources

Roquinimex inhibits dextran sodium sulfate-induced murine colitis

Inflammation Research, 2003
Roquinimex is a modulator of the immune system and has been shown to attenuate induction of several inflammatory and autoimmune diseases. The objective of the present study was to determine the efficacy of roquinimex in a model of murine colitis.For this purpose, Balb/c mice were exposed to 5% dextran sodium sulfate (DSS) in the drinking water for five
Q, Liu, Y, Wang, M X, Wan, X W, Zhang, G, Andersson, G, Hedlund, H, Thorlacius   +6 more
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Carcinogenicity of dextran sulfate sodium in relation to its molecular weight

Cancer Letters, 1983
The carcinogenicity of dextran and 3 kinds of dextran sulfate sodium with different molecular weights and almost the same sulfur content were compared in ACI rats. Dextran sulfate sodium of molecular weight 54,000 showed a strong carcinogenic activity when it was given orally as 2.5% diet, whereas dextran sulfate sodium of molecular weight 520,000 and ...
I, Hirono, K, Kuhara, T, Yamaji, S, Hosaka, L, Golberg   +4 more
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Dextran sodium sulfate alters cytokine production in macrophages in vitro

Die Pharmazie, 2016
Macrophages have been assumed to have a crucial role in the development of inflammatory bowel disease (IBD). However, involvement of intestinal macrophages in IBD onset and functional alterations of macrophages during IBD development has not been clarified.
Kono, Y., Miyoshi, S., Fujita, T.
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Effect of Adiponectin on Murine Colitis Induced by Dextran Sulfate Sodium

Gastroenterology, 2006
Adiponectin, an adipose tissue-derived hormone, exhibits anti-inflammatory properties and has various biological functions, such as increasing insulin sensitivity, reducing hypertension, and suppressing atherosclerosis, liver fibrosis, and tumor growth.
Tamao, Nishihara, Morihiro, Matsuda, Hiroshi, Araki, Kazuya, Oshima, Shinji, Kihara, Tohru, Funahashi, Iichiro, Shimomura   +6 more
openaire   +2 more sources

Venular Constriction of Submucosal Arterioles Induced by Dextran Sodium Sulfate

Inflammatory Bowel Diseases, 2005
Leukocyte and platelet adherence in postcapillary venules has been speculated to induce constriction of closely paired arterioles. This mechanism was investigated in the current study, in a model of intestinal inflammation induced by dextran sodium sulfate (DSS; 5,000 molecular weight).Closely paired, parallel arterioles and venules in the submucosa of
Norman R, Harris, Joseph R, Whatley, Patsy R, Carter, Robert D, Specian   +3 more
openaire   +2 more sources