Results 1 to 10 of about 650,495 (350)

Dextran sulfate-based MMP-2 enzyme-sensitive SR-A receptor targeting nanomicelles for the treatment of rheumatoid arthritis

Drug Delivery, 2022
Rheumatoid arthritis (RA) is an ordinarily occurring autoimmune disease with systemic inflammatory. Targeted drug delivery systems have many successful applications in the treatment of rheumatoid arthritis.
Caiwei Yu, Hui Liu, Chunjing Guo, Qiang Chen, Yanguo Su, Huimin Guo, X. Hou, Feng Zhao, Huaying Fan, Hui Xu, Yan Zhao, Xiaofeng Mu, Guohua Wang, Haiyu Xu, Daquan Chen   +14 more
semanticscholar   +3 more sources

Dextran Sulfate Sodium Salt-Induced Colitis Aggravates Gut Microbiota Dysbiosis and Liver Injury in Mice With Non-alcoholic Steatohepatitis

Frontiers in Microbiology, 2021
Objective: Inflammatory bowel disease (IBD) is characterized by gut microbiota dysbiosis, which is also frequently observed in patients with non-alcoholic fatty liver disease.
Bo Shen, Bo Shen, Junjun Wang, Junjun Wang, Yuecheng Guo, Yuecheng Guo, Tianyi Gu, Tianyi Gu, Zhenyang Shen, Zhenyang Shen, Cui Zhou, Cui Zhou, Binghang Li, Binghang Li, Xianjun Xu, Xianjun Xu, Fei Li, Fei Li, Qidi Zhang, Qidi Zhang, Xiaobo Cai, Xiaobo Cai, Hui Dong, Hui Dong, Lungen Lu, Lungen Lu   +25 more
doaj   +2 more sources

Dextran Sulfate Sodium (DSS)‐Induced Colitis in Mice [PDF]

Current Protocols in Immunology, 2014
AbstractInflammatory bowel diseases (IBD), mainly comprising ulcerative colitis and Crohn's Disease, are complex and multifactorial diseases with unknown etiology. For the past 20 years, to study human IBD mechanistically, a number of murine models of colitis have been developed. These models are indispensable tools to decipher underlying mechanisms of
Benoit, Chassaing, Jesse D, Aitken, Madhu, Malleshappa, Matam, Vijay-Kumar   +3 more
openaire   +3 more sources

Mechanisms of intermolecular interaction of mitoxantrone with targeted delivery polyelectrolyte capsules [PDF]

Известия Саратовского университета. Новая серия: Физика, 2021
Background and Objectives: Polyelectrolyte capsules are one of the most promising materials for targeted drug delivery – one of the rapidly developing areas of modern chemistry, pharmacology and medicine.
Plastun, Inna L'vovna, Naumov, Anatoly A., Zakharov, Alexander A.   +2 more
doaj   +1 more source

Expanding the utility of the dextran sulfate sodium (DSS) mouse model to induce a clinically relevant loss of intestinal barrier function [PDF]

PeerJ, 2020
Background Inflammatory bowel disease (IBD) is a family of debilitating disorders that affects more than 1 million people in the United States. Many animal studies of IBD use a dextran sulfate sodium (DSS) mouse model of colitis that induces rapid and ...
Kyle E. Cochran, Nicholas G. Lamson, Kathryn A. Whitehead   +2 more
doaj   +2 more sources

Akkermansia muciniphila Alleviates Dextran Sulfate Sodium (DSS)-Induced Acute Colitis by NLRP3 Activation

Microbiology spectrum, 2021
The gut microbiota and host immune response interaction influences the progression of intestinal inflammatory disease. As a well-recognized next-generation probiotic, Akkermansia muciniphila has been proved to play a crucial role in the progression of ...
Siwen Qu, Lina Fan, Yadong Qi, Chaochao Xu, Yingying Hu, Shujie Chen, Wei Liu, Weili Liu, Jianmin Si   +8 more
semanticscholar   +1 more source

Dextran Sulfate Nanocarriers: Design, Strategies and Biomedical Applications

International Journal of Molecular Sciences, 2022
Dextran sulfate (DXS) is a hydrophilic, non-toxic, biodegradable, biocompatible and safe biopolymer. These biomedically relevant characteristics make DXS a promising building block in the development of nanocarrier systems for several biomedical ...
Subramaniyan Ramasundaram, G. Saravanakumar, S. Sobha, T. Oh   +3 more
semanticscholar   +1 more source

Monitoring heparin therapy: stability of two different anti-Xa assays using blood samples collected in citrate-containing and CTAD tubes

Thrombosis Journal, 2023
Background Anti-factor Xa assays and activated partial thromboplastin time (aPTT) are mainly employed to monitor patients treated with heparins. According to the Clinical and Laboratory Standards Institute and the French Working Group on Haemostasis and ...
Marion Gremillet, Laurie Talon, Aurélien Lebreton, Thomas Sinegre   +3 more
doaj   +1 more source

Dextran sodium sulfate (DSS) induces colitis in mice by forming nano-lipocomplexes with medium-chain-length fatty acids in the colon. [PDF]

PLoS ONE, 2012
Inflammatory bowel diseases (IBDs), primarily ulcerative colitis and Crohn's disease, are inflammatory disorders caused by multiple factors. Research on IBD has often used the dextran sodium sulfate (DSS)-induced colitis mouse model.
Hamed Laroui, Sarah A Ingersoll, Hong Chun Liu, Mark T Baker, Saravanan Ayyadurai, Moiz A Charania, Famina Laroui, Yutao Yan, Shanthi V Sitaraman, Didier Merlin   +9 more
doaj   +1 more source

Dimethyl Fumarate Alleviates Dextran Sulfate Sodium-Induced Colitis, through the Activation of Nrf2-Mediated Antioxidant and Anti-inflammatory Pathways. [PDF]

, 2020
Oxidative stress and chronic inflammation play critical roles in the pathogenesis of ulcerative colitis (UC) and inflammatory bowel diseases (IBD). A previous study has demonstrated that dimethyl fumarate (DMF) protects mice from dextran sulfate sodium ...
Farzaneh, Ted, Ichii, Hirohito, Lau, Hien, Li, Shiri, Robles, Lourdes, Stamos, Michael J, Takasu, Chie, Vaziri, Nosratola D, Vo, Kelly   +8 more
core   +2 more sources