Results 241 to 250 of about 98,592 (289)

Dextran Sulfate Sodium-Induced Colitis in Immunodeficient Rats

Digestive Diseases and Sciences, 2000
To examine the morphology of colitis and study the role of the immune system in colitis, we compared colitis in immunocompetent Wistar-Kyoto rats with that in spontaneously hypertensive rats, known to have T-cell dysfunction. Rats were treated with 3% dextran sulfate in drinking water for periods ranging from 3 to 60 days.
K, Shichijo, M, Gottfried, I, Sekine, T N, Pappas   +3 more
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Zearalenone can relieve dextran sulfate sodium‐induced inflammatory reaction

Journal of Biochemical and Molecular Toxicology, 2018
AbstractIn this study, we investigated the influence of zearalenone (ZEA) on the dextran sulfate sodium (DSS)‐induced colitis model both in vitro and in vivo. Our results show that the mRNA levels of IL‐1β, IL‐18, NLRP3, ASC, and caspase‐1 in the DSS+ZEA‐treated group are lower than those in either the DSS or ZEA group, and the protein expression ...
Chenchen Ding, Wentao Fan, Tongtong Shen, Kehe Huang, Suquan Song, Liping Yan   +5 more
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Embelin ameliorates dextran sodium sulfate-induced colitis in mice

International Immunopharmacology, 2011
Embelin has been used to treat fever, inflammatory diseases, and a variety of gastrointestinal ailments for thousands of years. Although reports indicate that embelin has anti-inflammatory and anti-tumor effects, its effects on ulcerative colitis have not been previously explored.
Kalyan, Kumar G, , Dhamotharan R, Nagaraj M, Kulkarni, Srinivasa, Honnegowda, , Murugesan S   +4 more
openaire   +2 more sources

Agaricus bisporusAttenuates Dextran Sulfate Sodium-Induced Colitis

Journal of Medicinal Food, 2014
Agaricus bisporus (white button mushroom, WBM) is widely consumed in most countries and is reported to have anti-inflammatory and antioxidant activities. However, little is known regarding its effects in dextran sulfate sodium (DSS)-induced colitis, which are related to dysfunction of intestinal immunity. The aim of the present study was to investigate
Min Young, Um, Jae Ho, Park, So Young, Gwon, Jiyun, Ahn, Chang Hwa, Jung, Tae Youl, Ha   +5 more
openaire   +2 more sources

Geranylgeranylacetone protects mice from dextran sulfate sodium-induced colitis

Scandinavian Journal of Gastroenterology, 2005
Geranylgeranylacetone (GGA) has recently been reported to induce heat shock protein (HSP) 70, which has a protective function against inflammation. We investigated the therapeutic effects of oral administration of GGA on dextran sulfate sodium (DSS)-induced colitis in mice.BALB/c mice were given 3% DSS solution orally for 7 days to induce colitis.
Tatsuya, Ohkawara, Jun, Nishihira, Hiroshi, Takeda, Kencho, Miyashita, Kanji, Kato, Mototsugu, Kato, Toshiro, Sugiyama, Masahiro, Asaka   +7 more
openaire   +2 more sources

Phenyl methimazole suppresses dextran sulfate sodium-induced murine colitis

European Journal of Pharmacology, 2010
Ulcerative colitis is an autoimmune-inflammatory disease characterized by abnormally increased expression of Toll-like receptor-4 (TLR4) in colonic epithelial cells, increased production of pro-inflammatory cytokines (e.g., TNF-alpha, IL-1beta, IL-6, IL-12), chemokines (e.g., IP-10), and endothelial cell adhesion molecules (e.g., VCAM-1), plus enhanced
Uruguaysito, Benavides, Mariana, Gonzalez-Murguiondo, Norikazu, Harii, Christopher J, Lewis, Harshad S, Sakhalkar, Sudhir P, Deosarkar, David T, Kurjiaka, Nilesh M, Dagia, Douglas J, Goetz, Leonard D, Kohn   +9 more
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Effect of Heparin on Dextran Sulfate Sodium-Induced Colitis

Digestive Diseases and Sciences, 1998
Heparin has been shown to ameliorate inflammatory bowel disease in several series. In addition to its anticoagulant properties, heparin has numerous other effects that may be beneficial in inflammatory bowel disease. Other sulfated polysaccharides, such as dextran sulfate, cause colitis in mice through unknown mechanisms.
J R, Korzenik, A, Hsu, M E, Robert
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Induction of Colitis in Young Rats by Dextran Sulfate Sodium

Digestive Diseases and Sciences, 2005
Models using dextran sulfate sodium (DSS) to induce experimental colitis in rodents have been performed mostly in adult animals. For this reason, we aimed to develop a model of colitis in young rats. DSS was administered to 30-day-old rats at concentrations ranging from 0.5 to 5% in drinking water.
María, Vicario, Mar, Crespí, Angels, Franch, Concepció, Amat, Carme, Pelegrí, Miquel, Moretó   +5 more
openaire   +3 more sources

The Severity of Dextran Sodium Sulfate-Induced Colitis Can Differ Between Dextran Sodium Sulfate Preparations of the Same Molecular Weight Range

Digestive Diseases and Sciences, 2011
We hypothesized that the severity of dextran sodium sulfate (DSS)-induced colitis could differ between DSS preparations of the same molecular weight, and that this difference may be affected by the sulfur content. To test this, we used three DSS preparations of similar molecular weights but with different sulfur contents.Three DSS preparations with ...
Shigeki, Bamba, Akira, Andoh, Hiromitsu, Ban, Hirotsugu, Imaeda, Tomoki, Aomatsu, Ayako, Kobori, Yosuke, Mochizuki, Makoto, Shioya, Takashi, Nishimura, Osamu, Inatomi, Masaya, Sasaki, Yasuharu, Saitoh, Tomoyuki, Tsujikawa, Yoshio, Araki, Yoshihide, Fujiyama   +14 more
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Dietary red raspberries attenuate dextran sulfate sodium-induced acute colitis

The Journal of Nutritional Biochemistry, 2018
Persistent intestinal inflammation severely impairs intestinal integrity resulting in inflammatory bowel disease. Red raspberries (RB) are a rich source of bioactive compounds; their beneficial effect on the colitis protection was evaluated in the current study using a dextran sulfate sodium (DSS)-induced acute colitis mouse model.
Shima, Bibi, Yifei, Kang, Min, Du, Mei-Jun, Zhu   +3 more
openaire   +2 more sources