Results 71 to 80 of about 98,007 (275)

Hydrogel‐Based Functional Materials: Classifications, Properties, and Applications

Advanced Materials Technologies, EarlyView.
Conductive hydrogels have emerged as promising materials for smart wearable devices due to their outstanding flexibility, multifunctionality, and biocompatibility. This review systematically summarizes recent progress in their design strategies, focusing on monomer systems and conductive components, and highlights key multifunctional properties such as
Zeyu Zhang, Zao Cheng, Patrizio Raffa
wiley   +1 more source

Regenerating Rat Liver: Correlations Between Estrogen Receptor Localization and Deoxyribonucleic Acid Synthesis [PDF]

, 1984
Estrogen receptor activity was quantitated in the cytosol and nucleus of normal rat liver and in regenerating rat liver at several time intervals after 75% hepatectomy. Cytosolic estradiol binding in regenerating liver decreases at 12, 24, and 48 h after
Di Leo, A, Eagon, PK, Francavilla, A, Ove, P, Starzl, TE, Van Thiel, DH, Wu, SQ   +6 more
core   +1 more source

Chronic Hypoxia Disrupts Spermatogenesis Through ASXL2–EZH2–Mediated Microtubule Destabilization

Advanced Science, EarlyView.
This study reveals the mechanism by which chronic hypoxia impairs spermatogenesis via the ASXL2–EZH2 axis, hindering the transition of spermatids from round to elongated forms. Key findings reveal that under hypoxic conditions, downregulated ASXL2 expression reduces EZH2 binding to the CEP162 promoter, leading to decreased H3K27me3 modification and ...
Jun Yin, Mengjie Zhang, Wenying Liu, Wenlong Shen, Debao Li, Hongming Miao, Fang Deng, Gang Zhang, Yi Tian, Yi Zhang, Zhihu Zhao, Bing Ni   +11 more
wiley   +1 more source

Infammatory bowel disease-associated ubiquitin ligase RNF183 promotes lysosomal degradation of DR5 and TRAIL-induced caspase activation [PDF]

, 2019
Open access.金沢大学医薬保健研究域医学系journal ...
30580394, Atsushi Saito, Fumika Sakaue, Kazunori Imaizumi, Koji Matsuhisa, Masayuki Kaneko, Rie Asada, Takumi Okamoto, Yan Wu, Yuka Kimura, 齋藤 敦   +10 more
core   +2 more sources

Colonic Epithelial Circadian Disruption Worsens Dextran Sulfate Sodium–Induced Colitis

Inflammatory Bowel Diseases, 2022
AbstractBackgroundDisruption of central circadian rhythms likely mediated by changes in microbiota and a decrease in gut-derived metabolites like short chain fatty acids (SCFAs) negatively impacts colonic barrier homeostasis. We aimed to explore the effects of isolated peripheral colonic circadian disruption on the colonic barrier in a mouse model of ...
Sarah B Jochum, Phillip A Engen, Maliha Shaikh, Ankur Naqib, Sherry Wilber, Shohreh Raeisi, Lijuan Zhang, Shiwen Song, Gabriella Sanzo, Vijit Chouhan, Frank Ko, Zoe Post, Laura Tran, Vivian Ramirez, Stefan J Green, Khashayarsha Khazaie, Dana M Hayden, Mark J Brown, Robin M Voigt, Christopher B Forsyth, Ali Keshavarzian, Garth R Swanson   +21 more
openaire   +2 more sources

Versatile CRISPR‐Cas Tools for Gene Regulation in Zebrafish via an Enhanced Q Binary System

Advanced Science, EarlyView.
This study introduces CRISPR‐Q, a transgenic CRISPR‐Cas system leveraging the QFvpr/QUAS binary expression platform in zebrafish. CRISPR‐Q overcomes previous challenges in achieving stable and efficient gene regulation. By enabling precise spatiotemporal control of transcript knockdown (CRISPR‐QKD) and gene activation (CRISPR‐Qa), it provides a ...
Miaoyuan Shi, Weiqi Ge, Changheng Li, Bin Liu, Xiaoyi Deng, Chengjie Liu, Meijun Zheng, Pu Zhang, Lei Li, Ying Guo, Yunqi Han, Yu Yang, Yanxun V. Yu, Youngnam N. Jin   +13 more
wiley   +1 more source

Anxiolytic effects of the flavonoid luteolin in a mouse model of acute colitis

Molecular Brain, 2019
Anxiety related disorders commonly occur in association with major depressive disorder (MDD) in individuals suffering from peripheral inflammation, with a higher prevalence among IBS patients.
Vinicius M. Gadotti, Gerald W. Zamponi
doaj   +1 more source

The effects of apolipoprotein B depletion on HDL subspecies composition and function[S]

Journal of Lipid Research, 2016
HDL cholesterol (HDL-C) efflux function may be a more robust biomarker of coronary artery disease risk than HDL-C. To study HDL function, apoB-containing lipoproteins are precipitated from serum.
W. Sean Davidson, Anna Heink, Hannah Sexmith, John T. Melchior, Scott M. Gordon, Zsuzsanna Kuklenyik, Laura Woollett, John R. Barr, Jeffrey I. Jones, Christopher A. Toth, Amy S. Shah   +10 more
doaj   +1 more source

Nasal Drug Delivery Systems: An Overview [PDF]

, 2015
Since ancient times, drugs have been administered via the nasal route for therapeutic and recreational purposes. The interest in, and importance, of the systemic effects of drugs administered through the nasal route, have expanded over recent decades ...
Conway, Barbara R., Ghori, Muhammad U., Mahdi, Mohammed H., Smith, Alan M.   +3 more
core   +1 more source

Glucosamine sulfate attenuates dextran sodium sulfate (DSS) induced colitis in mice

The FASEB Journal, 2013
Glucosamine is a widely used supplement among patients with osteoarthritis. Also, it has been shown that glucosamine exhibits anti‐inflammatory action through the suppression of neutrophil activation. In this study, efficacy of glucosamine supplementation to attenuates DSS‐induced colitis. C57BL/6 mice were separated into three groups (n=10/group).
Youn‐Kyung Bak, Johanna W. Lampe, Mi‐Kyung Sung   +2 more
openaire   +1 more source