Dextran sulfate activates contact system and mediates arterial hypotension via B2 kinin receptors [PDF]
, 1994 To define some of the mechanisms underlying dextran sulfate (DXS)-induced hypotension, we investigated the effects of either the plasma kallikrein inhibitor des-Pro2-[Arg15] aprotinin (BAY x 4620) or the specific bradykinin B2-receptor antagonist Hoe-140
Cheronis, John C. +7 more
core +4 more sources
Role of the protein annexin A1 on the efficacy of anti-TNF treatment in a murine model of acute colitis [PDF]
, 2016 TNF-α is involved in the mechanisms that initiate inflammatory bowel diseases (IBDs). Anti-TNF-α drugs, such as infliximab (IFX), cause non-responsiveness and side effects, indicating the need to investigate alternative therapies for these diseases.
Barrios, Bibiana Elisabet +6 more
core +1 more source
Frontiers in Microbiology, 2019 Viral entry mechanisms of herpesviruses constitute a highly complex process which implicates several viral glycoproteins and different receptors on the host cell surfaces. This initial infection stage was currently undescribed for Ostreid herpes virus 1 (
Claire Martenot +6 more
doaj +1 more source
Biomedicines, 2021 Heparins, unfractionated or low molecular weight, are permanently in the spotlight of both clinical indications and laboratory monitoring. An accurate drug dosage is necessary for an efficient and safe therapy.
Jean Amiral +2 more
doaj +1 more source
Biotin Supplementation Ameliorates Murine Colitis by Preventing NF-κB Activation. [PDF]
, 2020 Background & aimsBiotin is a water-soluble vitamin that is indispensable for human health. Biotin deficiency can cause failure-to-thrive, immunodeficiency, alopecia, dermatitis, and conjunctivitis.
Cahalan, Michael D +5 more
core
Paramagnetic, Silicon Quantum Dots for Magnetic Resonance and Two-Photon Imaging of Macrophages [PDF]
, 2010 Quantum dots (QDs) are an attractive platform for building multimodality imaging probes, but the toxicity for typical cadmium QDs limits enthusiasm for their clinical use.
Kauzlarich, Susan M. +4 more
core +3 more sources
The influence of natural pulmonary surfactant on the efficacy of siRNA-loaded dextran nanogels [PDF]
, 2013 Aim: Topical administration of siRNA nanocarriers is a promising approach in the treatment of pulmonary disorders. Pulmonary surfactant, covering the entire alveolar surface of mammalian lungs, will be one of the first interfaces that siRNA nanocarriers ...
Braeckmans, Kevin +4 more
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Effects of dextran and dextran sulfate on the glucoamylase-catalyzed reaction.
Agricultural and Biological Chemistry, 1977 The hydrolysis of maltose by glucoamylase (EC 3. 2. 1. 3 from Rhizopus niveus) was carried out in the presence and absence of dextran and dextran sulfate, which are the components of supports of immobilized enzymes. The interaction between dextran and the enzyme was observed by the fluorescence spectrophotometry.
Shuji Adachi +3 more
openaire +2 more sources
Unique Mode of Antiviral Action of a Marine Alkaloid against Ebola Virus and SARS-CoV-2
Viruses, 2022 Lamellarin α 20-sulfate is a cell-impenetrable marine alkaloid that can suppress infection that is mediated by the envelope glycoprotein of human immunodeficiency virus type 1.
Mai Izumida +9 more
doaj +1 more source
Differential effects of α4β7 and GPR15 on homing of effector and regulatory T cells from patients with UC to the inflamed gut in vivo [PDF]
, 2015 Objective: Gut homing of lymphocytes via adhesion molecules has recently emerged as new target for therapy in inflammatory bowel diseases. We aimed to analyze the in vivo homing of effector (Teff) and regulatory (Treg) T cells to the inflamed gut via ...
Agace +64 more
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