Dextran sulfate enhances the level of an oxidative DNA damage biomarker, 8-oxo-7,8-dihydro-2 0-deoxyguanosine, in rat colonic mucosa [PDF]
, 1998 Dextran sodium sulfate (DSS) given in drinking water can induce colonic Inflammation and produce colorectal tumors in rodents, although it is not directly genotoxic.
Petit, Claude +5 more
core
Dextran sulfate promotes the rapid aggregation of porcine bone-marrow stromal cells
, 1995 Despite the fact that cells of the mammalian stromal compartment of bone marrow have been shown to contain multipotential stem cells when studied in diffusion chambers it is notable that the same range of possible phenotypes (e.g., chondrocytic) has not ...
N. Loveridge +3 more
core +1 more source
Lithium induces intestinothrophic effects in the healthy colon, but does not ameliorate dextran sulfate sodium-induced colitis in mice [PDF]
, 2012 Background & aims: Ulcerative colitis is characterized by severe damage of the colon epithelium. Wnt-signaling is important for repair and regeneration of the intestinal epithelium.
Blokzijl, Tjasso +8 more
core +1 more source
Antiplatelet agents’-ticagrelol and eptifibatide-safety in experimental colitis in mice
The Turkish Journal of Gastroenterology, 2020 Background/Aims: To evaluate the side effects of two antiplatelet agents - ticagrelor and eptifibatide - in mice with experimentally-induced inflammatory bowel disease. Methods and Material: This study was designed as a controlled, animal, drug safety
Stanko S. Petrovic +12 more
doaj +1 more source
Multifunctional role of dextran sulfate sodium for in vivo modeling of intestinal diseases [PDF]
BMC Immunology, 2012 Abstract Background Inflammatory bowel diseases (IBDs) are chronic, relapsing disorders that affect the gastrointestinal tract of millions of people and continue to increase in incidence each year. While several factors have been associated with development of IBDs, the exact etiology is unknown. Research using animal
Rose William A +2 more
openaire +3 more sources
Green Soybean Extract Ameliorates Dextran Sodium Sulfate-Induced Colitis
Natural Product Communications, 2018 Green-mature soybean ( Glycine max ) extract (GSE) inhibits the progression of immunoglobulin E-mediated inflammation more than the ordinary yellow-pigmented soybean extract (YSE).
Yuko Yoshikawa +6 more
doaj +1 more source
The Influence of Ghrelin on the Development of Dextran Sodium Sulfate-Induced Colitis in Rats [PDF]
BioMed Research International, 2015 Ghrelin has protective and therapeutic effects in the gut. The aim of present studies was to investigate the effect of treatment with ghrelin on the development of colitis evoked by dextran sodium sulfate (DSS). Methods. Studies have been performed on rats. Colitis was induced by adding 5% DSS to the drinking water for 5 days.
Matuszyk, Aleksandra +10 more
openaire +3 more sources
Cellular and Molecular Gastroenterology and Hepatology, 2021 Background & Aims: Neuroinflammation in the gut is associated with many gastrointestinal (GI) diseases, including inflammatory bowel disease. In the brain, neuroinflammatory conditions are associated with blood-brain barrier (BBB) disruption and ...
David Dora +10 more
doaj +1 more source
Involvement of lymphocytes in dextran sulfate sodium-induced experimental colitis
World Journal of Gastroenterology, 2006 To investigate the roles of lymphocytes in the development of dextran sulfate sodium-induced colitis.Using various doses of dextran sulfate sodium (DSS), we induced colitis in wild-type B6 control and Rag-1 knockout (H-2b haplotype) mice, and evaluated the colitis in terms of symptomatic and histologic parameters, such as weight loss, survival ...
Tae Woon, Kim +6 more
openaire +2 more sources
Novel FXR agonist nelumal A suppresses colitis and inflammation-related colorectal carcinogenesis
Scientific Reports, 2021 FXR is a member of the nuclear receptor superfamily and bile acids are endogenous ligands of FXR. FXR activation has recently been reported to inhibit intestinal inflammation and tumour development.
Tsuneyuki Miyazaki +13 more
doaj +1 more source