Results 41 to 50 of about 38,524 (332)

Test of the 'glymphatic' hypothesis demonstrates diffusive and aquaporin-4-independent solute transport in rodent brain parenchyma

eLife, 2017
Transport of solutes through brain involves diffusion and convection. The importance of convective flow in the subarachnoid and paravascular spaces has long been recognized; a recently proposed ‘glymphatic’ clearance mechanism additionally suggests that ...
Alex J Smith, Xiaoming Yao, James A Dix, Byung-Ju Jin, Alan S Verkman   +4 more
doaj   +1 more source

Aqueous Angiography: Real-Time and Physiologic Aqueous Humor Outflow Imaging. [PDF]

PLoS ONE, 2016
PURPOSE:Trabecular meshwork (TM) bypass surgeries attempt to enhance aqueous humor outflow (AHO) to lower intraocular pressure (IOP). While TM bypass results are promising, inconsistent success is seen.
Sindhu Saraswathy, James C H Tan, Fei Yu, Brian A Francis, David R Hinton, Robert N Weinreb, Alex S Huang   +6 more
doaj   +1 more source

Formation of Microcages from a Collagen Mimetic Peptide via Metal-Ligand Interactions

Molecules, 2021
Here, the hierarchical assembly of a collagen mimetic peptide (CMP) displaying four bipyridine moieties is described. The CMP was capable of forming triple helices followed by self-assembly into disks and domes.
Jeremy Gleaton, Ryan W. Curtis, Jean Chmielewski   +2 more
doaj   +1 more source

Specific modulation of airway epithelial tight junctions by apical application of an occludin peptide [PDF]

, 2006
Tight junctions are directly involved in regulating the passage of ions and macromolecules (gate functions) in epithelial and endothelial cells. The modulation of these gate functions to transiently regulate the paracellular permeability of large solutes
Barozzi, Nadia, Everett, Ruth S., Johnson, Larry G., Toth, Istvan, Vanhook, Miriam K.   +4 more
core   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

COMPARISON OF THE EFFICACY OF HYDROXYPROPYL METHYLCELLULOSE/ DEXTRAN, SODIUM HYALURONATE AND POLYETHYLENE GLYCOL/PROPYLENE GLYCOL BASED COMMERCIAL ARTIFICIAL TEAR PRODUCTS USING THE NONINVASIVE TEAR FILM BREAKUP TIME

Pakistan Armed Forces Medical Journal, 2020
Objective: To compare the efficacy of sodium hyaluronate, hydroxypropyl methylcellulose/dextran and polypropylene/polyethylene glycol based commercial artificial tear products using the noninvasive tear film breakup time.
Faisal Aziz Khan, Shafaq Pervez Khan Niazi, Irshad Hussain   +2 more
doaj  

Identification of amino acids essential for angulin‐1/3 binding of the tricellular tight junction binder, angubindin‐1

FEBS Open Bio, EarlyView.
Angubindin‐1 binds angulin‐1/‐3 at tricellular tight junctions, enhancing intestinal macromolecule permeation. Alanine scanning identified six essential residues (L562, L598, E638, V640, Y643, and K644) of angubindin‐1 critical for binding to angulin‐1/‐3 and permeation‐enhancing activity, providing insights for the development of targeted noninvasive ...
Taiki Kuzu, Yumi Iwashita, Keisuke Tachibana, Itsuki Nishino, Yuki Niwa, Atsuko Uyeda, Kazuki Matsuo, Masahiro Nagahama, Masuo Kondoh   +8 more
wiley   +1 more source

Transdermal delivery of FITC-Dextrans with different molecular weights using radiofrequency microporation

Biomaterials Research, 2020
Background Transdermal delivery is of great importance for the effective delivery of bioactive or therapeutic agents into a body. The microporation device based on radiofrequency can be used to enhance delivery efficiency by removing the epidermis layer.
Guk Young Ahn, Hae-Seok Eo, Dongwon Kim, Sung-Wook Choi   +3 more
doaj   +1 more source

Dextrans in Aqueous Solution. Experimental Review on Intrinsic Viscosity Measurements and Temperature Effect [PDF]

, 2014
The study of biopolymers as dextran in aqueous solution, is effectively determined by intrinsic viscosity [η] measurements at different temperatures. Molecular weight (Mv) and hydrodynamic properties can be calculated from there.
Masuelli, Martin Alberto
core   +2 more sources

Understanding bio‐based polymers: A study of origins, properties, biodegradation and their impact on health and the environment

FEBS Open Bio, EarlyView.
This review provides an overview of bio‐based polymer sources, their unique functional properties and their environmental impact, and addresses their role as sustainable alternatives. It discusses end‐of‐life options, including composting and anaerobic digestion for renewable energy.
Sabina Kolbl Repinc, Blaž Stres, Mirica Karlovits, Igor Karlovits, Petra Jerič, Ondrej Panák, Anja Verbič, Blaž Likozar, Uroš Novak   +8 more
wiley   +1 more source