Results 11 to 20 of about 634,910 (313)

Downregulation of hepatic lncRNA Gm19619 improves gluconeogenesis and lipogenesis following vertical sleeve gastrectomy in mice

Communications Biology, 2023
A hepatic lncRNA Gm19619, which is repressed by vertical sleeve gastrectomy but upregulated by obesity and fasting, regulates gluconeogenesis and lipid metabolism in mice through Foxo1-G6pc/Pck1 and Lepr signaling pathway respectively.
Zhipeng Fang, Mingjie Fan, Dongqiang Yuan, Lihua Jin, Yangmeng Wang, Lili Ding, Senlin Xu, Jui Tu, Eryun Zhang, Xiwei Wu, Zhen Bouman Chen, Wendong Huang   +11 more
doaj   +1 more source

Renal protection induced by physical exercise may be mediated by the irisin/AMPK axis in diabetic nephropathy

Scientific Reports, 2022
In patients with diabetes, it has been suggested that physical exercise may reduce albuminuria and the progression of renal disease. However, the molecular mechanism by which physical exercise protects the kidney in diabetes remains poorly understood ...
Guilherme Pedron Formigari, Marcella Neves Dátilo, Beatriz Vareda, Ivan Luiz Padilha Bonfante, Claudia Regina Cavaglieri, Jacqueline M. Lopes de Faria, José B. Lopes de Faria   +6 more
doaj   +1 more source

Characterization of the renal cortical transcriptome following Roux-en-Y gastric bypass surgery in experimental diabetic kidney disease

BMJ Open Diabetes Research & Care, 2020
Introduction Roux-en-Y gastric bypass surgery (RYGB) reduces albuminuria and the long-term incidence of end-stage renal disease in patients with obesity and diabetes.
Carel W le Roux, Neil G Docherty, Lars Fändriks, Meera Nair, William P Martin, Vadim Zhernovkov, Naomi Fearon, Hans Eckhardt, Janet McCormack, Catherine Godson, Eoin Patrick Brennan   +10 more
doaj   +1 more source

Bile Acid–Mediated Activation of Brown Fat Protects From Alcohol-Induced Steatosis and Liver Injury in MiceSummary

Cellular and Molecular Gastroenterology and Hepatology, 2022
Background & Aims: Alcohol-associated liver disease (AALD) is one of the most common causes of liver injury and failure. Limited knowledge of the mechanisms underlying AALD impedes the development of efficacious therapies.
Mingjie Fan, Yangmeng Wang, Lihua Jin, Zhipeng Fang, Jiangling Peng, Jui Tu, Yanjun Liu, Eryun Zhang, Senlin Xu, Xiaoqian Liu, Yuqing Huo, Zhaoli Sun, Xiaojuan Chao, Wen-Xing Ding, Qingfeng Yan, Wendong Huang   +15 more
doaj   +1 more source

Vertical sleeve gastrectomy reverses diet-induced gene-regulatory changes impacting lipid metabolism

Scientific Reports, 2017
Vertical sleeve gastrectomy (VSG) produces sustainable weight loss, remission of type 2 diabetes (T2D), and improvement of nonalcoholic fatty liver disease (NAFLD).
Juan Du, Jingyan Tian, Lili Ding, Candi Trac, Brian Xia, Siming Sun, Dustin E. Schones, Wendong Huang   +7 more
doaj   +1 more source

Extracellular arginine availability modulates eIF2α O-GlcNAcylation and heme oxygenase 1 translation for cellular homeostasis

Journal of Biomedical Science, 2023
Background Nutrient limitations often lead to metabolic stress during cancer initiation and progression. To combat this stress, the enzyme heme oxygenase 1 (HMOX1, commonly known as HO-1) is thought to play a key role as an antioxidant. However, there is
Yu-Wen Hung, Ching Ouyang, Xiaoli Ping, Yue Qi, Yi-Chang Wang, Hsing-Jien Kung, David K. Ann   +6 more
doaj   +1 more source

Regulation of angiotensin II actions by enhancers and super-enhancers in vascular smooth muscle cells

Nature Communications, 2017
The repertoire of tissue-specific distal regulators of gene transcription enhancers defines homeostasis or disease. Here, the authors reveal the enhancer and super-enhancer signature of vascular smooth muscle cells under normal and angiotensin II stimuli,
Sadhan Das, Parijat Senapati, Zhuo Chen, Marpadga A. Reddy, Rituparna Ganguly, Linda Lanting, Varun Mandi, Anita Bansal, Amy Leung, Selena Zhang, Ye Jia, Xiwei Wu, Dustin E. Schones, Rama Natarajan   +13 more
doaj   +1 more source

Liraglutide dictates macrophage phenotype in apolipoprotein E null mice during early atherosclerosis

Cardiovascular Diabetology, 2017
Background Macrophages play a pivotal role in atherosclerotic plaque development. Recent evidence has suggested the glucagon-like peptide-1 receptor (GLP-1R) agonist, liraglutide, can attenuate pro-inflammatory responses in macrophages.
Robyn Bruen, Sean Curley, Sarina Kajani, Daniel Crean, Marcella E. O’Reilly, Margaret B. Lucitt, Catherine G. Godson, Fiona C. McGillicuddy, Orina Belton   +8 more
doaj   +1 more source

Publisher Correction: miR-379 deletion ameliorates features of diabetic kidney disease by enhancing adaptive mitophagy via FIS1

Communications Biology, 2021
A Correction to this paper has been published: https://doi.org/10.1038/s42003-021-01691 ...
Mitsuo Kato, Maryam Abdollahi, Ragadeepthi Tunduguru, Walter Tsark, Zhuo Chen, Xiwei Wu, Jinhui Wang, Zhen Bouman Chen, Feng-Mao Lin, Linda Lanting, Mei Wang, Janice Huss, Patrick T. Fueger, David Chan, Rama Natarajan   +14 more
doaj   +1 more source

Diabetic Ketoacidosis Complicating Gestational Diabetes Mellitus

AACE Clinical Case Reports, 2022
The prevalence of diabetic ketoacidosis (DKA) in gestational diabetes mellitus (GDM) is very low. We describe a patient with GDM in whom severe DKA with intrauterine fetal demise developed in the setting of nonadherence to therapy.A 33-year-old woman, G2P0010, with no preexisting diabetes mellitus (DM) presented at 30 weeks of gestation with acute ...
Camila Alejandra Villavicencio, Alberto Franco-Akel, Regina Belokovskaya   +2 more
openaire   +3 more sources