Results 31 to 40 of about 1,073,655 (357)

Extracellular arginine availability modulates eIF2α O-GlcNAcylation and heme oxygenase 1 translation for cellular homeostasis

Journal of Biomedical Science, 2023
Background Nutrient limitations often lead to metabolic stress during cancer initiation and progression. To combat this stress, the enzyme heme oxygenase 1 (HMOX1, commonly known as HO-1) is thought to play a key role as an antioxidant. However, there is
Yu-Wen Hung, Ching Ouyang, Xiaoli Ping, Yue Qi, Yi-Chang Wang, Hsing-Jien Kung, David K. Ann   +6 more
doaj   +1 more source

Diabetes and kidney cancer: A direct or indirect association? [PDF]

, 2010
A positive association between diabetes and kidney cancer has been reported in several investigations, but it is unclear whether diabetes or its complications account for this association.
Bahij S. Nuwayhid, Eva L. Evans, Rohit P. Ojha, Tabatha N. Powell, Zuber D. Mulla   +4 more
core   +2 more sources

Regulation of angiotensin II actions by enhancers and super-enhancers in vascular smooth muscle cells

Nature Communications, 2017
The repertoire of tissue-specific distal regulators of gene transcription enhancers defines homeostasis or disease. Here, the authors reveal the enhancer and super-enhancer signature of vascular smooth muscle cells under normal and angiotensin II stimuli,
Sadhan Das, Parijat Senapati, Zhuo Chen, Marpadga A. Reddy, Rituparna Ganguly, Linda Lanting, Varun Mandi, Anita Bansal, Amy Leung, Selena Zhang, Ye Jia, Xiwei Wu, Dustin E. Schones, Rama Natarajan   +13 more
doaj   +1 more source

Liraglutide dictates macrophage phenotype in apolipoprotein E null mice during early atherosclerosis

Cardiovascular Diabetology, 2017
Background Macrophages play a pivotal role in atherosclerotic plaque development. Recent evidence has suggested the glucagon-like peptide-1 receptor (GLP-1R) agonist, liraglutide, can attenuate pro-inflammatory responses in macrophages.
Robyn Bruen, Sean Curley, Sarina Kajani, Daniel Crean, Marcella E. O’Reilly, Margaret B. Lucitt, Catherine G. Godson, Fiona C. McGillicuddy, Orina Belton   +8 more
doaj   +1 more source

Publisher Correction: miR-379 deletion ameliorates features of diabetic kidney disease by enhancing adaptive mitophagy via FIS1

Communications Biology, 2021
A Correction to this paper has been published: https://doi.org/10.1038/s42003-021-01691 ...
Mitsuo Kato, Maryam Abdollahi, Ragadeepthi Tunduguru, Walter Tsark, Zhuo Chen, Xiwei Wu, Jinhui Wang, Zhen Bouman Chen, Feng-Mao Lin, Linda Lanting, Mei Wang, Janice Huss, Patrick T. Fueger, David Chan, Rama Natarajan   +14 more
doaj   +1 more source

Increased mitochondrial proton leak and glycolysis in peripheral blood mononuclear cells in type-1-diabetes

Heliyon, 2022
Changes in cellular bioenergetics such as mitochondrial respiration and glycolysis may play a role in the pathogenesis of various diseases including type 1 diabetes (T1D).
Joana Mendes Lopes de Melo, Jens Christian Laursen, Niels Søndergaard-Heinrich, Ida Kirstine Bull Rasmussen, Christian Stevns Hansen, Marie Frimodt-Møller, Peter Rossing, Joachim Størling   +7 more
doaj   +1 more source

Complications of Diabetes 2016

Journal of Diabetes Research, 2016
The prevalence of diabetes (DM) is constantly increasing worldwide at an alarming rate. According to the International Diabetes Federation in 2015, an estimated 415 million people globally were suffering from this condition [1]. Complications of DM account for increased morbidity, disability, and mortality and represent a threat for the economies of ...
Konstantinos Papatheodorou, Nikolaos Papanas, Maciej Banach, Dimitrios Papazoglou, Michael Edmonds   +4 more
openaire   +3 more sources

Epigenetics of diabetic complications [PDF]

Expert Review of Endocrinology & Metabolism, 2010
Type 1 and Type 2 diabetes are complex diseases associated with multiple complications, and both genetic and environmental factors have been implicated in these pathologies. While numerous studies have provided a wealth of knowledge regarding the genetics of diabetes, the mechanistic pathways leading to diabetes and its complications remain only partly
Louisa M, Villeneuve, Rama, Natarajan
openaire   +2 more sources

Type 1 diabetes and cardiovascular disease [PDF]

, 2013
The presence of cardiovascular disease (CVD) in Type 1 diabetes largely impairs life expectancy. Hyperglycemia leading to an increase in oxidative stress is considered to be the key pathophysiological factor of both micro- and macrovascular complications.
Cappuccio, Francesco, Ceriello, Antonio, Genovese, Stefano, Schnell, Oliver, Standl, E. (Eberhard), Valensi, Paul   +5 more
core   +2 more sources

The AGE receptor, OST48 drives podocyte foot process effacement and basement membrane expansion (alters structural composition)

Endocrinology, Diabetes & Metabolism, 2021
Aims The accumulation of advanced glycation end products is implicated in the development and progression of diabetic kidney disease. No study has examined whether stimulating advanced glycation clearance via receptor manipulation is reno‐protective in ...
Aowen Zhuang, Felicia Y. T. Yap, Danielle J. Borg, Domenica McCarthy, Amelia Fotheringham, Sherman Leung, Sally A. Penfold, Karly C. Sourris, Melinda T. Coughlan, Benjamin L. Schulz, Josephine M. Forbes   +10 more
doaj   +1 more source