Results 51 to 60 of about 37,693 (353)

Dysfunctional TRIM31 of POMC Neurons Provokes Hypothalamic Injury and Peripheral Metabolic Disorder under Long‐Term Fine Particulate Matter Exposure

Advanced Science, EarlyView.
Particulate matter ≤2.5 µm (PM2.5) elevates risks of neurological and chronic metabolic diseases, but the underlying mechanisms linking PM2.5‐induced central nervous system (CNS) injury to metabolic dysfunction remain unclear. Hypothalamic pro‐opiomelanocortin‐expressing (POMC+) neurons regulate systemic metabolic homeostasis, and tripartite motif ...
Chenxu Ge, Jiamao Lin, Changsheng Yang, Chuanwang Miao, Fengxiang Li, Shuqiang Zhao, Lei Zou, Xuedong Teng, Lina Liu, Tingguang Li, Yan Sun, Qiang Li, Deshuai Lou, Linfeng Hu, Xi Liu, Gang Kuang, Jing Luo, Minxuan Xu, Minghui Chang, Jun Tan, Yanrong Ren, Bochu Wang   +21 more
wiley   +1 more source

Coping of diabetic nephropathy in the family: an approach in perspective Calgary Family Assessment Model. A qualitative study

Online Brazilian Journal of Nursing, 2007
This work tries to understand how a family faces the care with one of its members with diagnosis of diabetic nephropathy during dialysis treatment. This is a qualitative study, conducted by the purposes of ethnographic method, which used the Calgary ...
Gisele Fráguas, Sônia Maria Soares
doaj   +2 more sources

TRIM56 Aggravates Cerebral Ischemia‐Reperfusion Injury via Inhibiting KLF4‐Activated Ferroptosis Signaling

Advanced Science, EarlyView.
This study reveals that the E3 ubiquitin ligase TRIM56 exacerbates neuronal ferroptosis and brain damage by mediating K48‐linked ubiquitination and degradation of KLF4, leading to suppression of the xCT/GSH/GPX4 axis. Targeting TRIM56 alleviates cerebral ischemia‐reperfusion injury in vivo and in vitro, highlighting its therapeutic potential.
Qiangping Wang, Shuang Li, Man Li, Wenke Zhou, Jianqing Zhang, Zhenfu Wu, Zhaoqi Mao, Juan Wan, Xinhao Tang, Baoping Zheng, Qiang Liu, Zhendong Li, Xiaobing Jiang, Qingping Wu, Youfan Ye, Haijun Wang   +15 more
wiley   +1 more source

Protein kinase R-like endoplasmic reticulum kinase pathway and diabetic kidney disease

Linchuang shenzangbing zazhi, 2020
Endoplasmic reticulum stress is closely related to the occurrence and development of diabetic kidney disease.As an important signaling pathway induced by endoplasmic reticulum stress,protein kinase R-like endoplasmic reticulum kinase(PERK)pathway can ...
庞欣欣, 彭紫凝, 邢玉凤, 张雅歌, 石秀杰, 韩佳瑞   +5 more
doaj  

The role of sirolimus in proteinuria in diabetic nephropathy rats [PDF]

Iranian Journal of Basic Medical Sciences, 2017
Objective(s): The aim of this study was to observe the impact of sirolimus on proteinuria in streptozotocin (STZ) induced diabetic rats. Materials and Methods: Rats were given a single injection of STZ to induce diabetic rat model.
JinJun Wang, ZiQiang Xu, BiCheng Chen, ShaoLing Zheng, Peng Xia, Yong Cai   +5 more
doaj   +1 more source

Statins and the vasculopathy of systemic sclerosis: potential therapeutic agents? [PDF]

, 2006
It has been postulated that endothelial cell injury is the initiating event in the pathogenesis of systemic sclerosis, causing attraction, attachment, migration and infiltration of activated T-cells and subsequent production of cytokines and growth ...
Derk, Chris T., Jimenez, Sergio A.
core   +2 more sources

Diabetic Nephropathy [PDF]

Clinical Journal of the American Society of Nephrology, 2013
Summary The National Institute of Diabetes and Digestive and Kidney Diseases-supported Kidney Research National Dialogue (KRND) asked the scientific community to formulate and prioritize research objectives that would improve our understanding of kidney function and disease.
Matthew D, Breyer, Thomas M, Coffman, Michael F, Flessner, Linda F, Fried, Raymond C, Harris, Christian J, Ketchum, Matthias, Kretzler, Robert G, Nelson, John R, Sedor, Katalin, Susztak   +9 more
openaire   +2 more sources

Microenvironment Self‐Adaptive Nanoarmor to Address Adhesion‐ and Colonization‐Related Obstacles in Impaired Intestine Promote Bacteriotherapy Against Parkinson's Disease

Advanced Science, EarlyView.
A microenvironment self‐adaptive nanoarmor is developed to effectively address the adhesion‐ and colonization‐related challenges posed by multiple physiological and pathological characteristics in the intestine. L. plantarum@MPN@CS showed significant therapeutic potential in treating Parkinson's disease (PD), a model for extraintestinal disorders, as ...
Limeng Zhu, Yuyu Wu, Yingjie Chen, Xiyi Chen, Xingjie Zan, Yanlong Liu, Wujun Geng   +6 more
wiley   +1 more source

The rs3844492/ARHGAP22 and rs741301/ELMO1 polymorphisms are associated with changes in laboratory markers of renal damage among patients with type 2 diabetes mellitus [PDF]

Archives of Endocrinology and Metabolism
Objective: To investigate the association between the rs3844492/ARHGAP22 and rs741301/ELMO1 polymorphisms and diabetic kidney disease in patients with type 2 diabetes mellitus.
Luciane Moretto, Eliandra Girardi, Anna Carolina Meireles Vieira, Letícia de Almeida Brondani, Natália Emerim Lemos, Luís Henrique Canani, Marilu Fiegenbaum, Cristine Dieter, Daisy Crispim   +8 more
doaj   +1 more source

Характерные особенности хронических прогрессирующих нефропатий в пожилом и старческом возрасте [PDF]

, 2012
Хронические прогрессирующие нефропатии в пожилом и старческом возрасте являются актуальной проблемой. Представлены вопросы этиологии, патогенеза, диагностики и лечения нефропатий. Хронические прогрессирующие нефропатии включают в себя: нефроангиосклероз,
Горелик, С. Г., Колпакова, Н. А., Мудраковская, Э. В.   +2 more
core