Results 71 to 80 of about 683,288 (403)

Erk5 is a mediator to TGFβ1-induced loss of phenotype and function in human podocytes. [PDF]

, 2014
Background: Podocytes are highly specialized cells integral to the normal functioning kidney, however, in diabetic nephropathy injury occurs leading to a compromised phenotype and podocyte dysfunction which critically produces podocyte loss with ...
Binder, Browne, Chuang, Dalla Vestra, Dessapt, Dorado, Drew, Fioretto, Gagliardini, Goldfarb, Hayashi, Herbach, Herman-Edelstein, Huang, Iwano, Khalil, Kim, Kim, Li, Maeda, Marchetti, Niculescu-Duvaz, Pavenstädt, Phanish, Reeves, Regan, Rocco, Saleem, Schiffer, Shishido, Siegel, Suzaki, Vardouli, Wahab, Winn, Woo, Wu, Zhou, Ziyadeh, Ziyadeh   +39 more
core   +2 more sources

Vasopressin and diabetic nephropathy [PDF]

Current Opinion in Nephrology and Hypertension, 2017
The prevalence of diabetic kidney disease (DKD) is increasing worldwide. Despite major therapeutic advances in the last decades in DKD, the current standard of care let many people progress to severe stages. Vasopressin secretion is increased in diabetes, and its potential role in the onset and progression of DKD is being re-investigated.Recently ...
Roussel, Ronan, Velho, Gilberto, Bankir, Lise   +2 more
openaire   +4 more sources

Algorithm and Related Application for Smart Wearable Devices to Reduce the Risk of Death and Brain Damage in Diabetic Coma [PDF]

J Diabetes Sci Technol May 2016 vol. 10 no. 3 802-803, 2015
Diabetes is an epidemic disease of the 21st century and is growing globally. Although, final diabetes treatments and cure are still on research phase, related complications of diabetes endanger life of diabetic patients. Diabetic coma which happens with extreme high or low blood glucose is one of the risk factor for diabetic patients and if it remains ...
arxiv   +1 more source

DNA‐PKcs‐Driven YAP1 Phosphorylation and Nuclear Translocation: a Key Regulator of Ferroptosis in Hyperglycemia‐Induced Cardiac Dysfunction in Type 1 Diabetes

Advanced Science, EarlyView.
In the context of chronic hyperglycemia, a DDR is initiated, leading to the pathological activation of DNA‐PKcs in the diabetic heart. This activated DNA‐PKcs directly interacts with and phosphorylates YAP1 at Thr226, thereby increasing the nuclear expression of YAP1.
Junyan Wang, Xing Chang, Chun Li, Jing Gao, Zhijiang Guo, Haowen Zhuang, Lingjun Wang, Yusheng Huang, Wei Wang, Chao Li, Qingyong He   +10 more
wiley   +1 more source

The role of renin angiotensin system inhibition in kidney repair [PDF]

, 2010
Chronic kidney diseases share common pathogenic mechanisms that, independently from the initial injury, lead to glomerular hyperfiltration, proteinuria, and progressive renal scarring and function loss.
Cravedi, Paolo, Remuzzi, Giuseppe, van der Meer, Irene M   +2 more
core   +2 more sources

Diabetic Nephropathy without Diabetes [PDF]

Journal of Clinical Medicine, 2015
Diabetic nephropathy without diabetes (DNND), previously known as idiopathic nodular glomerulosclerosis, is an uncommon entity and thus rarely suspected; diagnosis is histological once diabetes is discarded. In this study we describe two new cases of DNND and review the literature. We analyzed all the individualized data of previous publications except
Elia Pérez Fernández, Ramona Ionela Stanescu, Katia López-Revuelta, Maria Isabel Martínez Marín, Angel A Méndez Abreu, Carmen Gerrero-Márquez   +5 more
openaire   +4 more sources

Clinical dichotomania: A major cause of over-diagnosis and over-treatment? [PDF]

arXiv, 2023
Introduction: There have been many warnings that inappropriate dichotomisation of results into positive or negative, high, or normal etc., during medical research could be very damaging. The aim of this paper is to argue that this is the main cause of over-diagnosis and over-treatment.
arxiv  

Diabetic Retinopathy: A Position Statement by the American Diabetes Association

Diabetes Care, 2017
Diabetic retinopathy diagnostic assessment and treatment options have improved dramatically since the 2002 American Diabetes Association Position Statement (1).
Sharon D. Solomon, E. Chew, E. Duh, L. Sobrin, Jennifer K. Sun, B. Vanderbeek, C. Wykoff, T. Gardner   +7 more
semanticscholar   +1 more source

Isoquercitrin Alleviates Diabetic Nephropathy by Inhibiting STAT3 Phosphorylation and Dimerization

Advanced Science, EarlyView.
This study identified a natural compound, isoquercitrin, which significantly alleviated kidney inflammation and fibrosis by inhibiting STAT3 activity. Isoquercitrin forms a strong, noncovalent bond that directly binds to STAT3. Isoquercitrin binds to the pY+1 pocket of the SH2 domain of STAT3 via hydrogen bonding with Ser668, Gln635, and Gln633 ...
Chen Xuan, Donghui Chen, Shuangna Zhang, Chaofan Li, Qingyun Fang, Dinghua Chen, Jiabao Liu, Xin Jiang, Yingjie Zhang, Wanjun Shen, Guangyan Cai, Xiangmei Chen, Ping Li   +12 more
wiley   +1 more source

Coping of diabetic nephropathy in the family: an approach in perspective Calgary Family Assessment Model. A qualitative study

Online Brazilian Journal of Nursing, 2007
This work tries to understand how a family faces the care with one of its members with diagnosis of diabetic nephropathy during dialysis treatment. This is a qualitative study, conducted by the purposes of ethnographic method, which used the Calgary ...
Gisele Fráguas, Sônia Maria Soares
doaj   +2 more sources