Results 301 to 310 of about 109,708 (338)

Monoclonal Antibody 5F1 Modulates Formyl Peptide Receptor 1 Conformation for Transmembrane Signaling

open access: yesFASEB BioAdvances, Volume 7, Issue 9, September 2025.
Schematic Illustration of 5F1's Role in FPR1 Modulation. Monoclonal antibody 5F1 predominantly binds to the extracellular loop 2 of FPR1 and is sensitive to the structural conformation of FPR1. This interaction leads to biased activation of Giα‐mediated signaling and β‐arrestin recruitment. Consequently, 5F1 exhibits potentially agonistic activities at
Yue Wang   +3 more
wiley   +1 more source

Lipid discovery enabled by sequence statistics and machine learning. [PDF]

open access: yesElife
Christensen PM   +7 more
europepmc   +1 more source

Anti‐Obesity Effects of Peucedanum Japonicum Thunb Root Extract With Induction of Hepatic Cyp2b10 Gene Expression in Mice

open access: yesJournal of Food Science, Volume 90, Issue 9, September 2025.
ABSTRACT Although Peucedanum japonicum Thunb (PJT) has been used in traditional medicine, PJT root is considered to be agricultural waste, and its benefits have not been explored to date. This study examined the effect of PJT root extract in C57BL/6J mice fed a high‐fat diet (HFD) for 10 weeks and determined the underlying molecular mechanisms based on
Rahmawati Aisyah   +9 more
wiley   +1 more source

Inhibition of diacylglycerol O-acyltransferase 1 provides neuroprotection by inhibiting ferroptosis in ischemic stroke. [PDF]

open access: yesMol Med
Zeng Y   +10 more
europepmc   +1 more source

Arylsulfamates inhibit colonic Bacteroidota growth through a sulfatase-independent mechanism. [PDF]

open access: yesProc Natl Acad Sci U S A
Crawford CJ   +14 more
europepmc   +1 more source

Cytidine diphosphate diacylglycerol synthase 2 is a synthetic lethal target in mesenchymal-like cancers. [PDF]

open access: yesNat Genet
Arnoldus T   +18 more
europepmc   +1 more source

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