Results 131 to 140 of about 73,225 (285)

Are we hallucinating or can psychedelic drugs modulate the immune system to control inflammation?

British Journal of Pharmacology, EarlyView.
Psychedelic drugs that activate 5‐HT2A receptors have been long used for cultural, medicinal and recreational purposes. Interest in psychedelics for treating psychiatric disorders has resurged recently and is well documented; less well recognised are their anti‐inflammatory properties. Growing evidence now demonstrates that psychedelics modulate immune
Omar Qureshi, Jamie Cowley, Ashley Pegg, Alison J. Cooper, John Gordon, Catherine A. Brady, Antonio Belli, Sam Butterworth, Rachel Upthegrove, Nick Andrews, Nicholas M. Barnes   +10 more
wiley   +1 more source

Characterization of AtDGK2 in relation to Contact Sites [PDF]

, 2019
Contact Sites are conserved cellular regions where two membranes of different organelles are very close but not merged. Contact sites between the endoplasmic reticulum (ER) and the plasma membrane (ER-PM CS) play important roles in metabolic functions ...
Botella-Mesa, Miguel Angel, García-Hernández, Selene, Ruiz-López, Noemi   +2 more
core  

Psychedelics as pharmacotherapeutics for substance use disorders: A scoping review on clinical trials and perspectives on underlying neurobiology

British Journal of Pharmacology, EarlyView.
Theorized mechanism of dopamine homeostasis restoration in the nucleus accumbens core induced by a psychedelic intervention. Abstract Psychedelics have garnered great attention in recent years as treatments for major depressive disorder (MDD) and treatment‐resistant depression because of their ability to alter consciousness and afflicted cognitive ...
Lucas Wittenkeller, Gary Gudelsky, T. John Winhusen, Davide Amato   +3 more
wiley   +1 more source

Binding of Vav to Grb2 through dimerization of Src homology 3 domains [PDF]

, 1994
The protooncogenic protein Vav has the structure of an intracellular signal transducer. It is exclusively expressed in cells of hematopoietic lineage and plays a crucial role in hematopoietic cell differentiation.
Baltimore, David, Ye, Zheng-Sheng
core  

The relationship between cytosolic Ca2+, sn-1,2-diacylglycerol and inositol 1,4,5-trisphosphate elevation in platelet-activating-factor-stimulated rabbit platelets. Influence of protein kinase C on production of signal molecules [PDF]

, 1991
Christine Murphy, M Elmore, Stuart Kellie, John Westwick   +3 more
openalex   +1 more source

Discovery‐Replication Strategy Identifies Serum Metabolite Biomarkers for Colorectal Cancer in a Chinese Cohort

Cancer Science, EarlyView.
This study used an untargeted metabolomics approach to screen for serum differentially abundant metabolites in colorectal cancer (CRC) patients, and after analyzing a discovery cohort and validation cohort, eight metabolites and their constituent panels were identified as not only having diagnostic value for CRC but also showing value for the early ...
Lugen Zuo, Bowen Song, Xuening Jiang, Jing Li, Xiaofeng Zhang, Lian Wang, Yueyue Wang, Zhijun Geng, Xue Song, Sitang Ge, Jianguo Hu   +10 more
wiley   +1 more source

FAM20C Modulates Neuronal Differentiation in Hypoxic–Ischemic Brain Damage via KAP1 Phosphorylation and LINE1 RNA m6A‐Dependent H3K9me3 Regulation

Cell Proliferation, EarlyView.
FAM20C regulates the composition of the YTHDC1‐NCL‐KAP1‐LINE1 RNAs complex, thereby affecting neuronal differentiation in hypoxic–ischemic brain damage (HIBD). ABSTRACT Neurodevelopmental impairment due to hypoxic–ischemic brain damage (HIBD) lacks effective biomarkers and therapeutic targets.
Chen‐xi Feng, Mei Wang, Gen Li, Si‐jia Chu, Di Wu, Xiao‐han Hu, Li‐xiao Xu, Mei Li, Xing Feng   +8 more
wiley   +1 more source

PI5P4K inhibitors: promising opportunities and challenges

The FEBS Journal, EarlyView.
Developing inhibitors is like climbing a steep, challenging mountain. PI5P4K inhibitors hold significant promise for the treatment of cancer, immune disorders, and neurological diseases. However, the path to success is fraught with hurdles, and researchers are therefore required to apply their expertise to overcome critical “checkpoints.” While some ...
Koh Takeuchi, Lisa Nagase, Shun Kageyama, Hirotaka Kanoh, Masashi Oshima, Aki Ogawa‐Iio, Yoshiki Ikeda, Yuki Fujii, Sei Kondo, Natsuki Osaka, Takeshi Masuda, Tsukasa Ishihara, Yoshikazu Nakamura, Yoshihisa Hirota, Takehiko Sasaki, Toshiya Senda, Atsuo T. Sasaki   +16 more
wiley   +1 more source

Diacylglycerol Kinase ζ Attenuates Doxorubicin‐Induced Cardiotoxicity Through p53 Degradation

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Doxorubicin‐induced cardiotoxicity is still an important medical problem associated with a high mortality rate in cancer survivors. p53 plays a key role in doxorubicin‐induced cardiotoxicity.
Shingo Tachibana, Yoichiro Otaki, Tetsu Watanabe, Jun Goto, Haruki Ochi, Toshiaki Tanaka, Hiroe Ono, Ryuhei Yamaguchi, Junya Sato, Hiroki Takahashi, Takanori Arimoto, Kaoru Goto, Masafumi Watanabe   +12 more
doaj   +1 more source

Correlation study of facial lipid profile differences and skin physiological characteristics in Chinese women aged 19–33 years

International Journal of Cosmetic Science, EarlyView.
The facial SC lipid profiles of young Chinese women in the early aging stage exhibited significant changes with age. The average chain length of diacylglycerol, triacylglycerol and short‐chain ceramides decreases with age, while the cholesteryl ester and ceramide EO subclasses increase. Some ceramides correlate positively with TEWL, skin elasticity and
Yumei Fan, Chunhua Wei, Ning Su, Yanyun Ma, Wei Liu, Peiwen Sun, Shuo Shan   +6 more
wiley   +1 more source