Results 161 to 170 of about 12,487 (210)

Diallyl trisulfide attenuates hyperglycemia-induced endothelial apoptosis by inhibition of Drp1-mediated mitochondrial fission. [PDF]

Acta Diabetol, 2019
Hao Y, Liu HM, Wei X, Gong X, Lu ZY, Huang ZH.   +5 more
europepmc   +1 more source

An oil-free microemulsion for intravenous delivery of diallyl trisulfide: Formulation and evaluation

International Journal of Pharmaceutics, 2011
The aim of the present study was to develop an oil-free o/w microemulsion, Cremophor EL:ethanol-propylene glycol:saline, for diallyl trisulfide (DATS) for intravenous (i.v.) administration to modify the safety and pharmacokinetics of DATS. The ternary diagram was constructed to identify the regions of dilutable microemulsions, and the optimal ...
Xinru Li, Yanxia Zhou
exaly   +4 more sources

Diallyl Trisulfide Inhibits Platelet Aggregation through the Modification of Sulfhydryl Groups

Journal of Agricultural and Food Chemistry, 2020
Diallyl trisulfide (DATS) is a secondary metabolite of allicin, a volatile organosulfur flavoring compound generated by the crushing of garlic. These compounds have various medicinal effects such as antiplatelet activity. In this study, we demonstrated for the first time the cellular mechanism involved in the inhibition of platelet aggregation by DATS ...
Takashi Hosono, Asuka Sato, Natsumi Nakaguchi, Yori Ozaki-Masuzawa, Taiichiro Seki   +4 more
core   +4 more sources

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Neuroprotective potential of phase II enzyme inducer diallyl trisulfide

Neurological Research, 2009
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease, selectively involving the upper and lower motor neurons. Glutamate excitotoxicity and oxidative stress are important mechanisms for the pathogenesis of ALS. Nuclear-factor erythroid 2-related factor 2 (Nrf2) is a master transcriptional regulator of many cytoprotective genes.
Hui Bu
exaly   +3 more sources

Effect of Diallyl Trisulfide on the Pharmacokinetics of Nifedipine in Rats

Journal of Food Science, 2011
Abstract:  This study aimed to evaluate the effect of diallyl trisulfide (DATS), a major component derived from garlic, on the pharmacokinetics of nifedipine. Pharmacokinetic parameters of nifedipine were determined in rats following an oral gavage (3 mg/kg) or intravenous administration (0.75 mg/kg) of ...
Gang Cheng
exaly   +3 more sources

Diallyl trisulfide suppresses the adipogenesis of 3T3-L1 preadipocytes through ERK activation

Food and Chemical Toxicology, 2012
Garlic and its organosulfur compounds display hypolipidemic effects by inhibiting fatty acid and cholesterol synthesis. We investigated the anti-adipogenic effect of diallyl trisulfide (DATS), the second most abundant organosulfide in garlic oil. We studied the effects of DATS in 3T3-L1 preadipocytes and the mechanism involved in its action. DATS (0-75
Chong-Kuei, Lii, Chun-Yin, Huang, Haw-Wen, Chen, Mun-Yew, Chow, Yu-Ru, Lin, Chin-Shiu, Huang, Chia-Wen, Tsai   +6 more
openaire   +3 more sources

Diallyl Trisulfide Intervention in Redox Homeostasis and Its Multitarget Antitumor Effects

Journal of Agricultural and Food Chemistry
Diallyl trisulfide (DATS), an organosulfur compound from the common food garlic, has been attracting attention by exhibiting low toxicity, tumor susceptibility, and, especially, multiple antitumor activities, despite its simple molecular structure. The mounting data suggest that the effects of DATS are related to its induction of oxidative stress cell ...
Xinyi Guo, Bo Su
openaire   +3 more sources

Effect of diallyl trisulfide on the pharmacokinetics of dipyridamole in rats

Archives of Pharmacal Research, 2011
This study was aimed to evaluate the effect of diallyl trisulfide (DATS), a major component derived from garlic used to inhibit platelet thromboxane formation, on the pharmacokinetics of dipyridamole. Pharmacokinetic parameters of dipyridamole were determined in rats following intragastric (80 mg/kg suspension or 40 mg/kg solution) or intravenous (3 mg/
Yue, Wang, Meijuan, Zou, Nan, Zhao, Jungang, Ren, Hong, Zhou, Gang, Cheng   +5 more
openaire   +2 more sources

Therapeutic discrepancy of diallyl trisulfide and diallyl disulfide in part may be attributed to the resonance-stabilization of allylic cations and trisulfide anions

Journal of Sulfur Chemistry, 2012
Accumulating pharmacological evidence has revealed that diallyl trisulfide (DATS) is uniquely active and its therapeutic effect prevails over diallyl disulfide (DADS). The cited reasons involve the bond dissociation energy, interconversion, lipophilicity, and polarizability of DATS.
Chiu-Lan Hsieh, Chi-Huang Chang, Hui-Er Wang, Kuan-Chou Chen, Charng-Cherng Chyau, Robert Y. Peng   +5 more
openaire   +1 more source

Protective effect of diallyl trisulfide on liver in rats with sepsis and the mechanism

Journal of Huazhong University of Science and Technology [Medical Sciences], 2012
The protective effects of diallyl trisulfide on liver were examined in rats with sepsis. Sepsis was reproduced in rats by cecum ligation and puncture (CLP). Fifty-six male Wistar rats were randomly divided into sham-operated group (group S, n=8), sepsis model group (group C, n=24), diallyl trisulfide (DATS)-treated group (group D, n=24).
Huawen, Chen, Wei, Zhu, Jun, Feng, Shusheng, Li   +3 more
openaire   +2 more sources