Results 161 to 170 of about 8,485 (177)

Preventive effect of Diallyl Trisulfide on cutaneous toxicities induced by EGFR inhibitor

International Immunopharmacology, 2019
Cutaneous toxicities are the commonest side effects in patients with cancer treated using epidermal growth factor receptor inhibitors such as erlotinib. For patients with such toxicities, there is a lack of safe, effective pharmacological agents. Here we established a skin toxicity model and investigated the preventive and therapeutic effect of Diallyl
Yuping Liu, Xiangliang Jiang, Yue Gu, Yan Chen   +3 more
openaire   +2 more sources

Raman spectroscopic characteristics of diallyl trisulfide acting on trans‐crotonaldehyde

Journal of Raman Spectroscopy, 2015
In this paper, the molecular mechanism of diallyl trisulfide (DATS) on trans‐crotonaldehyde (TCA) was studied by UV–vis absorption and Raman spectroscopies combining with density functional theory calculations. Experimental results indicate that the introduction of DATS can not only make the maximum absorption peak of TCA shift 15 nm, but also ...
Yanbin Su, Lei Chen, Yingkun Cheng, Fengrong Zhang, Yanwen Su, Zhengqiang Li   +5 more
openaire   +1 more source

Arsenic-induced hepatic mitochondrial toxicity in rats and its amelioration by diallyl trisulfide

Toxicology Mechanisms and Methods, 2013
The present investigation was aimed to investigate the possible protective role of diallyl trisulfide (DATS) against arsenic (As)-induced hepatic mitochondrial toxicity in rats. Mitochondria were isolated from the liver tissue of rats from all the groups.
S, Miltonprabu, N C, Sumedha
openaire   +2 more sources

Anticancer effects of diallyl trisulfide derived from garlic.

Asia Pacific journal of clinical nutrition, 2008
Alk(en)yl sulfides are characteristic flavor components of garlic. Several lines of epidemiological study indicate that the risk of a certain cancer can be prevented by consumption of garlic. In this manuscript, we examined the anticancer property of garlic-derived alk(en)yl sulfides, and the molecular basis especially for diallyl trisulfide which is a
Taiichiro, Seki, Takashi, Hosono, Tomomi, Hosono-Fukao, Kahoru, Inada, Rie, Tanaka, Jun, Ogihara, Toyohiko, Ariga   +6 more
openaire   +1 more source

Diallyl sulfide, diallyl disulfide and diallyl trisulfide affect drug resistant gene expression in colo 205 human colon cancer cells in vitro and in vivo

Phytomedicine, 2012
To elevate chemo-resistance of human cancer cells is a major obstacle in the treatment and management of malignant cancers. Diallyl sulfide (DAS), diallyl disulfide (DADS) and diallyl trisulfide (DATS) are presented in the Alliaceae family particularly in garlic.
Kuang-Chi, Lai, Chao-Lin, Kuo, Heng-Chien, Ho, Jai-Sing, Yang, Chia-Yu, Ma, Hsu-Feng, Lu, Hui-Ying, Huang, Fu-Shin, Chueh, Chien-Chih, Yu, Jing-Gung, Chung   +9 more
openaire   +2 more sources

Diallyl Trisulfide Intervention in Redox Homeostasis and Its Multitarget Antitumor Effects

Journal of Agricultural and Food Chemistry
Abstract Diallyl trisulfide (DATS), an organosulfur compound from the common food garlic, has been attracting attention by exhibiting low toxicity, tumor susceptibility, and, especially, multiple antitumor activities, despite its simple molecular structure.
Xinyi Guo, Bo Su
openaire   +2 more sources

Diallyl trisulfide and diallyl disulfide ameliorate cardiac dysfunction by suppressing apoptotic and enhancing survival pathways in experimental diabetic rats

Journal of Applied Physiology, 2013
Cardiovascular disease is one of the major causes of mortality in diabetic patients. Mounting studies have shown that garlic exhibits, possibly through its antioxidant potential, diverse biological activities. In this study, we investigated the alleviating effects of garlic oil (GO) and its two major components, diallyl disulfide (DADS) and diallyl ...
Yao-Te, Huang, Chun-Hsu, Yao, Chia-Li, Way, Kung-Wei, Lee, Cheng-Yen, Tsai, Hsiu-Chung, Ou, Wei-Wen, Kuo   +6 more
openaire   +2 more sources

Preparation and stability of diallyl trisulfide self-assembled micellar injection.

PDA journal of pharmaceutical science and technology, 2016
Diallyl trisulfide (DATS) has shown various biological activities, such as antimicrobial, antihyperlipidemic, antithrombotic, and anticancer effects. It is a highly water insoluble thioether compound, which irritates blood vessels and degrades rapidly under normal conditions.
Xiulan, Ju, Shixuan, Zhang, Qing, Wang, Xiaona, Li, Puwen, Yang   +4 more
openaire   +1 more source

Simultaneous determination of diallyl trisulfide and diallyl disulfide in rat blood by gas chromatography with electron-capture detection.

Die Pharmazie, 2007
A simple, rapid and sensitive method has been developed and validated for the simultaneous quantification of diallyl trisulfide (DATS) and diallyl disulfide (DADS) in rat blood by gas chromatography with electron-capture detection. The analytes were prevented from degradation by addition of acetonitrile and extraction with hexane before gas ...
X, Sun, T, Guo, J, He, M, Zhao, M, Yan, F, Cui, Y, Deng   +6 more
openaire   +1 more source

Antimicrobial Effect and the Mechanism of Diallyl Trisulfide Against Campylobacter jejuni

Antibiotics, 2021
Dan Gu, Huang Jinlin, Xin'an Jiao
exaly