Results 151 to 160 of about 8,485 (177)

Effect of diallyl trisulfide on the pharmacokinetics of dipyridamole in rats

Archives of Pharmacal Research, 2011
This study was aimed to evaluate the effect of diallyl trisulfide (DATS), a major component derived from garlic used to inhibit platelet thromboxane formation, on the pharmacokinetics of dipyridamole. Pharmacokinetic parameters of dipyridamole were determined in rats following intragastric (80 mg/kg suspension or 40 mg/kg solution) or intravenous (3 mg/
Yue, Wang, Meijuan, Zou, Nan, Zhao, Jungang, Ren, Hong, Zhou, Gang, Cheng   +5 more
openaire   +2 more sources

Therapeutic discrepancy of diallyl trisulfide and diallyl disulfide in part may be attributed to the resonance-stabilization of allylic cations and trisulfide anions

Journal of Sulfur Chemistry, 2012
Accumulating pharmacological evidence has revealed that diallyl trisulfide (DATS) is uniquely active and its therapeutic effect prevails over diallyl disulfide (DADS). The cited reasons involve the bond dissociation energy, interconversion, lipophilicity, and polarizability of DATS.
Chiu-Lan Hsieh, Chi-Huang Chang, Hui-Er Wang, Kuan-Chou Chen, Charng-Cherng Chyau, Robert Y. Peng   +5 more
openaire   +1 more source

Protective effect of diallyl trisulfide on liver in rats with sepsis and the mechanism

Journal of Huazhong University of Science and Technology [Medical Sciences], 2012
The protective effects of diallyl trisulfide on liver were examined in rats with sepsis. Sepsis was reproduced in rats by cecum ligation and puncture (CLP). Fifty-six male Wistar rats were randomly divided into sham-operated group (group S, n=8), sepsis model group (group C, n=24), diallyl trisulfide (DATS)-treated group (group D, n=24).
Huawen, Chen, Wei, Zhu, Jun, Feng, Shusheng, Li   +3 more
openaire   +2 more sources

In vitro anti-synovial sarcoma effect of diallyl trisulfide and mRNA profiling

Gene, 2022
Synovial sarcoma (SS) is a malignant soft tissue sarcoma and its natural history is a long, indolent clinical course followed by high rate of local recurrence and distant metastasis. Current therapies are still limited in increasing satisfactory of 5-year survival, especially for patients with recurrence and metastasis.
Sheng-Li, Xia, Zi-Yuan, Ma, Bin, Wang, Feng, Gao, Cun-Guo, Yi, Xiao-Xiao, Zhou, Sheng-Yang, Guo, Li, Zhou   +7 more
openaire   +2 more sources

Effect of Diallyl Trisulfide on the Pharmacokinetics of Nifedipine in Rats

Journal of Food Science, 2011
Abstract:  This study aimed to evaluate the effect of diallyl trisulfide (DATS), a major component derived from garlic, on the pharmacokinetics of nifedipine. Pharmacokinetic parameters of nifedipine were determined in rats following an oral gavage (3 mg/kg) or intravenous administration (0.75 mg/kg) of ...
Yue, Wang, Mei-Juan, Zou, Nan, Zhao, Jun-Gang, Ren, Hong, Zhou, Gang, Cheng   +5 more
exaly   +3 more sources

Degradation Urushiol Coating Composition Crosslinked by Diallyl Trisulfide

Journal of Polymers and the Environment, 2020
Urushiol (UR) was a kind of natural paint with a long history and excellent performance. Its high price restricts its development. For the sake of the sustainable development of UR, we prepared a new urushiol based coating composition which is of degradation.
Hanyu Xue, Yuchi Zhang, Xinzhong Li, Jianrong Xia, Qi Lin   +4 more
openaire   +1 more source

An Oil-Free Microemulsion for Intravenous Delivery of Diallyl Trisulfide: Formulation and Evaluation

International Journal of Pharmaceutics, 2011
The aim of the present study was to develop an oil-free o/w microemulsion, Cremophor EL:ethanol-propylene glycol:saline, for diallyl trisulfide (DATS) for intravenous (i.v.) administration to modify the safety and pharmacokinetics of DATS. The ternary diagram was constructed to identify the regions of dilutable microemulsions, and the optimal ...
xinru Li, Yanxia Zhou, Yanqing Huang
exaly   +3 more sources

Diallyl trisulfide ameliorates arsenic induced dyslipidemia in rats

Food Science and Biotechnology, 2015
The efficacy of diallyl trisulfide (DATS) against arsenic (As) induced dyslipidemia in the plasma and livers of rats was studied.
Selvaraj Miltonprabu, Naorem Chanu Sumedha   +1 more
openaire   +1 more source

Diallyl Disulfide and Diallyl Trisulfide Protect Endothelial Nitric Oxide Synthase Against Damage by Oxidized Low-Density Lipoprotein

Molecular Nutrition and Food Research, 2010
AbstractGarlic is viewed as an effective health food against atherosclerosis. In this study, we examined whether diallyl disulfide (DADS) and diallyl trisulfide (DATS) protect endothelial nitric oxide synthase (eNOS) activation against oxidized LDL (ox‐LDL) insult and through what mechanism.
Lee-Yan Sheen, Haw-Wen Chen, Chong-Kuei Lii   +2 more
exaly   +4 more sources

Effect of diallyl trisulfide on the activation of T cell and macrophage-mediated cytotoxicity

Journal of Tongji Medical University, 1994
At high concentration (50 micrograms/ml), diallyl trisulfide (DATS) had an inhibitory effect on T cell activation (compared with control group, P < 0.05). But at appropriate concentrations (3.125-12.5 micrograms/ml), DATS augmented the activation of T lymphocytes by Con A (compared with control group, P < 0.01). The augmentation of T cell activation by
Z H, Feng, G M, Zhang, T L, Hao, B, Zhou, H, Zhang, Z Y, Jiang   +5 more
openaire   +2 more sources